Fluid handling devices with diamond-like films

• US 6,749,813 B1
• Filed: 03/05/2000
• Issued: 06/15/2004
• Est. Priority Date: 03/05/2000
• Status: Expired due to Term

• Current Assignee: 3M Innovative Properties Company (3M Company)
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: David, Moses M., Gates, Brian J., Haddad, Louis C., Lee, Nicholas A.
• Primary Examiner(s): ALEXANDER, LYLE
• Application Number:
  US09/519,448
• Time in Patent Office: 1,563 Days
• Field of Search: 422/99-104, 428/216, 436/165
• US Class Current: 422/502
• CPC Class Codes: C23C 16/26 Deposition of carbon only
• CPC Class Codes: C23C 16/30 Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
• CPC Class Codes: G01N 30/6052 body
• CPC Class Codes: G01N 30/6078 Capillaries
• CPC Class Codes: G01N 30/6082 transparent to radiation
• CPC Class Codes: G01N 30/6095 Micromachined or nanomachined, e.g. micro- or nanosize
• CPC Class Codes: Y10T 428/24975 No layer or component greater than 5 mils thick

Abstract

Fluid handling devices including a substrate with a diamond-like film. The devices include capillaries and microfluidic articles.

Claims

1. A fluid handling device comprising a substrate and an optically transmissive diamond-like film disposed on at least a portion of the substrate, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen.

2. The fluid handling device of claim 1 comprising a capillary having an internal surface and an external surface, wherein at least a portion of at least one of the internal or external surfaces includes an optically transmissive diamond-like film disposed thereon.

3. The fluid handling device of claim 2 wherein the external surface of the capillary includes an optically transmissive diamond-like film disposed on at least a portion thereof.

4. The fluid handling device of claim 1 comprising a microfluidic article comprising a microfluidic handling architecture comprising a fluid handling surface, wherein at least a portion of the fluid handling surface includes an optically transmissive diamond-like film disposed thereon.

5. The fluid handling device of claim 4 wherein the optically transmissive diamond-like film is also hydrophilic.

6. The fluid handling device of claim 4 comprising:

a first non-elastic, polymeric substrate comprising a first major surface that includes the microfluidic handling architecture and a second major surface; and

a second polymeric substrate that is integrally bonded to said second major surface of said fist substrate, wherein the second substrate is capable of forming a free-standing substrate in the absence of said first substrate.

7. The fluid handling device of claim 4 comprising a cover layer on the microfluidic handling architecture.

8. The fluid handling device of claim 7 wherein the cover layer is bonded to the first major surface of the first substrate.

9. The fluid handling device of claim 4 wherein the microfluidic handling architecture comprises selected from the group consisting of microchannels, fluid reservoirs, sample handling regions, and combinations thereof.

10. The fluid handling device of claim 9 wherein at least one of the structures comprises a fluid handling surface, at least a portion of which has the optically transmissive diamond-like film disposed thereon.

11. The fluid device of claim 4 comprising a first polymeric substrate comprising a first major surface that includes a plurality of microfluidic handling architectures and a second major surface, wherein the article is in the form of a roll.

12. The fluid handling device of claim 1 wherein the optically transmissive diamond-like film has disposed thereon linking agents and a reactant affixed to the linking agents to form a binding site.

13. The fluid handling device of claim 12 wherein the linking agents are covalently attached to the diamond-like film.

14. The fluid handling device of claim 12 wherein the reactant is selected from the group consisting of nucleic acids, proteins, and carbohydrates.

15. The fluid handling device of claim 1 wherein the diamond-like film is also hydrophilic.

16. A fluid handling device comprising a microfluidic article comprising a microfluidic handling architecture comprising a fluid handling surface wherein at least portion of the fluid handling surface includes a hydrophilic diamond-like film disposed thereon, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen.

17. A fluid handling device comprising a substrate and an optically transmissive and hydrophilic film disposed on at least a portion of the substrate, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic oxygen, and further wherein the film has an extinction coefficient of no greater than 0.010 at 250 nm.

18. A fluid handling device comprising a substrate and a diamond-like glass film comprising a dense random covalent system comprising at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen, on a hydrogen-free basis, disposed on at least a portion of the substrate.

19. The fluid handling device of claim 18 comprising a capillary having an internal surface and an external surface, wherein at least a portion of at least one of the internal or external surfaces has the film disposed thereon.

20. The fluid handling device of claim 19 wherein at least a portion of the external surface of the capillary has the film disposed thereon.

21. The fluid handling device of claim 18 comprising a microfluidic article comprising a microfluidic handling architecture including a fluid handling surface wherein at least a portion of the fluid handling surface has the film disposed thereon.

22. A fluid handling device comprising a microfluidic article comprising microfluidic handling architecture including a fluid handling surface wherein at least a portion thereof has disposed thereon a film comprising diamond-like glass which comprises a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen.

23. A fluid handing device comprising a microfluidic article comprising a microfluidic handling architecture including a non-fluid handling surface wherein at least a portion thereof has disposed thereon a diamond-like film that is optically transmissive, hydrophilic, or both, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen.

24. A method of manufacturing a fluid handling device comprising a microfluidic article comprising a microfluidic handling architecture comprising a fluid handling surface wherein at least a portion of the fluid handling surface includes a hydrophilic diamond-like film disposed thereon, the method comprising manufacturing a hydrophilic diamond-like film by a method comprising treating a diamond-like film in an oxygen-containing plasma, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen.

25. A fluid handling device comprising a substrate and an optically transmissive diamond-like film disposed on at least a portion of the substrate, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen and further wherein the film exhibits substantially no fluorescence.

26. A fluid handling device comprising a microfluidic article comprising a microfluidic handling architecture comprising a fluid handling surface wherein at least a portion of the fluid handling surface includes a hydrophilic diamond-like film disposed thereon, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen, and further wherein the film exhibits substantially no fluorescence.

27. A fluid handling device comprising a substrate and an optically transmissive diamond-like film disposed on at least a portion of the substrate, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen, and further wherein the film is at least 50 percent transmissive to radiation at one or more wavelengths from about 180 to about 800 nanometers.

28. A fluid handling device comprising a microfluidic article comprising a microfluidic handling architecture comprising a fluid handling surface wherein at least a portion of the fluid handling surface includes a hydrophilic diamond-like film disposed thereon, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen, and further wherein the film is at least 50 percent transmissive to radiation at one or more wavelengths from about 180 to about 800 nanometers.

29. A method of manufacturing a fluid handling device comprising a microfluidic article comprising a microfluidic handling architecture comprising a fluid handling surface wherein at least a portion of the fluid handling surface includes a hydrophilic diamond-like film disposed thereon, the method comprising manufacturing a hydrophilic diamond-like film by a method comprising treating a diamond-like film in an oxygen-containing plasma, wherein the film comprises diamond-like glass comprising a dense random covalent comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen, and further wherein the film exhibits substantially no fluorescence.

30. A method of manufacturing a fluid handling device comprising a microfluidic article comprising a microfluidic handling architecture comprising a fluid handling surface wherein at least a portion of the fluid handling surface includes a hydrophilic diamond-like film disposed thereon, the method comprising manufacturing a hydrophilic diamond-like film by a method comprising a diamond-like film in an oxygen-containing plasma, wherein the film comprises diamond-like glass comprising a dense random covalent system comprising on a hydrogen-free basis at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen, and further wherein the film is at least 50 percent transmissive to radiation at one or more wavelengths from about 180 to about 800 nanometers.