Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
First Claim
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1. A system for measuring hemoglobin concentrations and hematocrit comprising:
- a pulsed optical source adapted to generate short optical pulses to provide irradiation of a blood vessel or tissue site;
an optical delivery system adapted to deliver the optical pulses to the blood vessel or tissue site, where the optical deliver system includes a proximal end in light communication with the source and a distal end out of which the optical pulses exit;
an adjustable probe including a housing, an acoustic transducer adapted to detect pressure waves resulting from the optical pulses impinging on the blood vessel or tissue site and mounted near a distal end of the probe, where the transducer has sufficient sensitivity, temporal resolution, and bandwidth to collect data from which a hemoglobin concentration can be derived and a cable connected to the transducer, where the probe is adapted to receive the distal end of the optical delivery system at its proximal end and situate the distal end of the optical delivery system flush with the housing at the distal end of the probe to provide appropriate irradiation conditions and acoustic contact between the blood vessel or tissue site and the acoustic transducer; and
an electronic signal recording and processing system connected to the cable where the signal recording and processing system includes a digital processing unit or computer calculating a hemoglobin concentration from the recorded optoacoustic pressure profiles and amplitudes.
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Abstract
An optoacoustic apparatus is disclosed which includes a radiation source of pulsed optical radiation and a probe having a front face to be placed in contact with a tissue site of an animal body. The probe further includes an optical fiber terminating at the surface of the front face of the probe and connected to a pulsed laser. The front face of the probe also has mounted therein or thereon a piezoelectric transducer for detecting an acoustic response to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of hemoglobin concentration and/or hematocrit of blood.
165 Citations
25 Claims
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1. A system for measuring hemoglobin concentrations and hematocrit comprising:
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a pulsed optical source adapted to generate short optical pulses to provide irradiation of a blood vessel or tissue site;
an optical delivery system adapted to deliver the optical pulses to the blood vessel or tissue site, where the optical deliver system includes a proximal end in light communication with the source and a distal end out of which the optical pulses exit;
an adjustable probe including a housing, an acoustic transducer adapted to detect pressure waves resulting from the optical pulses impinging on the blood vessel or tissue site and mounted near a distal end of the probe, where the transducer has sufficient sensitivity, temporal resolution, and bandwidth to collect data from which a hemoglobin concentration can be derived and a cable connected to the transducer, where the probe is adapted to receive the distal end of the optical delivery system at its proximal end and situate the distal end of the optical delivery system flush with the housing at the distal end of the probe to provide appropriate irradiation conditions and acoustic contact between the blood vessel or tissue site and the acoustic transducer; and
an electronic signal recording and processing system connected to the cable where the signal recording and processing system includes a digital processing unit or computer calculating a hemoglobin concentration from the recorded optoacoustic pressure profiles and amplitudes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A system for measuring hemoglobin concentrations and hematocrit comprising:
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a pulsed optical source adapted to generate short optical pulses;
an optical delivery system including a proximal end in light communication with the source and a distal end out of which the optical pulses exit, where the system is adapted to deliver the optical pulses to a blood vessel;
an adjustable probe including a housing including a distal end and a proximal end, an acoustic transducer mounted in the distal end of the housing and having sufficient sensitivity, temporal resolution, and bandwidth to collect data from which a hemoglobin concentration can be derived, an optical mount mounted in the distal end of the housing into which the distal end of the optical deliver system is inserted, and a cable connected to the transducer at its proximal end, where the transducer is adapted to detect pressure waves resulting from the optical pulses impinging on the blood vessel, where the distal end of the housing is adapted to provide appropriate irradiation and acoustic contact between the blood vessel and the optical delivery system and transducer mounted in the distal end of the housing; and
an electronic signal recording and processing system including a digital processing unit, where the recording and processing system is connected to a distal end of the cable and adapted to receive and record transducer generated optoacoustic pressure profiles and amplitudes and where the digital processing unit is adapted to calculate a hemoglobin concentration from the recorded optoacoustic pressure profiles and amplitudes. - View Dependent Claims (22, 23, 24, 25)
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Specification