Analyte measuring biosensor chip using image scanning system
First Claim
1. A biosensor system comprising:
- an implantable analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a body fluid in a body in which the hydrogel slab is implanted; and
scanning means configured to quantifiably detect changes in the displacement volume of the hydrogel slab when it is implanted within the body by capturing an image of at least a portion of the hydrogel slab.
2 Assignments
0 Petitions
Accused Products
Abstract
An implantable chip biosensor for detecting an analyte in vivo in body fluids comprises an analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte, such as glucose, in a patient'"'"'s body fluid, the slab being disposed in a groove in a support block. The biosensor chip is ‘read’ by an external scanner configured to quantifiably detect changes in the displacement volume of the hydrogel slab. The support block is made of rigid or semi-rigid support material to restrain expansion of the hydrogel in all but one dimension, and the groove has one or more openings covered with a semipermeable membrane to allow contact between the patient'"'"'s body fluid and the hydrogel. The scanning means may be any type of imaging devices such as an ultrasound scanner, a magnetic resonance imager (MRI), or a computerized tomographic scanner (CT) capable of resolving changes in the slab'"'"'s dimensions.
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Citations
68 Claims
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1. A biosensor system comprising:
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an implantable analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a body fluid in a body in which the hydrogel slab is implanted; and
scanning means configured to quantifiably detect changes in the displacement volume of the hydrogel slab when it is implanted within the body by capturing an image of at least a portion of the hydrogel slab.
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2. A biosensor system comprising:
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an implantable analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a body fluid in a body in which the hydrogel slab is implanted;
wherein the hydrogel slab is disposed in a support block formed of a rigid or semi-rigid support material, the support block having one or more openings permitting the body fluid to contact the hydrogel; and
scanning means configured to quantifiably detect changes in the displacement volume of the hydrogel slab when it is implanted within the body. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 30)
a quantity of glucose-binding moieties immobilized therein, and a quantity of complementary molecules immobilized therein, said complementary molecules configured to selectively bind to said glucose-binding moieties. -
20. The biosensor system of claim 2, wherein the support material is selected from the group consisting of:
- Teflon, rigid or semi-rigid plastics, stainless steel, ceramics, and composite materials.
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30. The biosensor system of claim 7, wherein the scanning unit further includes wireless transmission means operably connected and configured to transmit an output signal reflective of the displacement volume or of the analyte concentration corresponding to the displacement volume to a remote monitoring device.
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21. A biosensor system comprising:
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an implantable analyte-sensitive hydrogel slab shaped as a filament having a lengthwise dimension Y which is substantially greater than first and second width dimensions X and Z, and chemically configured to vary its displacement volume according to changes in concentration of an analyte in a body fluid in a body in which the hydrogel slab is implanted;
a support block formed of a support material, said hydrogel filament being disposed within the support block; and
scanning means configured to quantifiably detect changes in the displacement volume of the hydrogel slab when it is implanted within the body. - View Dependent Claims (22, 23, 24, 25, 26)
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27. A biosensor system comprising:
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an implantable analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a body fluid in a body in which the hydrogel slab is implanted; and
ultrasound detection means configured to quantifiably detect changes in the displacement volume of the hydrogel slab when it is implanted within the body. - View Dependent Claims (28, 29, 31, 32)
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33. A biosensor system comprising:
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an implantable analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a body fluid in a body in which the hydrogel slab is implanted; and
means for magnetic resonance scanning capable of detecting changes in the displacement volume of the hydrogel slab when it is implanted within the body.
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34. A biosensor system comprising:
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an implantable analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a body fluid in a body in which the hydrogel slab is implanted; and
means for computerized tomography capable of detecting changes in the displacement volume of the hydrogel slab when it is implanted within the body.
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35. An implantable biosensor chip for implantation into a patient'"'"'s body comprising:
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a support block formed of rigid or semi-rigid, biocompatible material, a groove in the support block having one or more openings permitting penetration of a patient'"'"'s body fluid, a semipermeable membrane configured to permit passage of the analyte and prevent passage of proteins into the groove; and
an analyte sensitive hydrogel slab disposed within the groove, said hydrogel slab being chemically configured to vary its displacement volume according to changes in concentration of an analyte in the body fluid, said hydrogel slab being further configured to be detectable by externally-based means for imaging body structures, said hydrogel slab being shaped as a filament having a length dimension Y which is substantially greater than first and second width dimensions X and Z, and wherein the groove is sized to permit expansion of the hydrogel slab in the length dimension and to substantially prevent expansion of the hydrogel slab in one or both of the width dimensions. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. An implantable biosensor chip for implantation into a patient'"'"'s body comprising:
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a support block formed of rigid or semi-rigid, biocompatible material;
a groove in the support block having one or more openings permitting penetration of a patient'"'"'s body fluid;
a semipermeable membrane configured to permit passage of the analyte and prevent passage of proteins into the groove;
an analyte sensitive hydrogel slab disposed within the groove, said hydrogel slab being chemically configured to vary its displacement volume according to changes in concentration of an analyte in the body fluid, and said hydrogel slab being further configured to be detectable by externally-based means for imaging body structures; and
scale means disposed on said support block and located adjacent the hydrogel slab for providing known scale dimensional values to compare with the hydrogel slab, said scale means being detectable in simultaneity with the hydrogel slab.
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47. An implantable biosensor chip for implantation into a patient'"'"'s body comprising:
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a support block formed of rigid or semi-rigid, biocompatible material, a groove in the support block having one or more openings permitting penetration of a patient'"'"'s body fluid, a semipermeable membrane configured to permit passage of the analyte and prevent passage of proteins into the groove;
an analyte sensitive hydrogel slab disposed within the groove, said hydrogel slab being chemically configured to vary its displacement volume according to changes in concentration of glucose in a human body fluid, and said hydrogel slab being further configured to be detectable by externally-based means for imaging body structures;
a quantity of glucose-binding moieties immobilized in the hydrogel; and
a quantity of complementary molecules immobilized in the hydrogel, said complementary molecules configured to selectively bind to said glucose-binding moieties. - View Dependent Claims (48, 49, 50)
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51. An implantable biosensor chip for implantation into a patient'"'"'s body comprising:
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a support block formed of rigid or semi-rigid, biocompatible material, a groove in the support block having one or more openings permitting penetration of a patient'"'"'s body fluid, said groove having three dimensions x, y, and z, and wherein the groove is sized to permit expansion of the hydrogel slab in the y-dimension only;
a semipermeable membrane configured to permit passage of the analyte and prevent passage of proteins into the groove; and
an analyte sensitive hydrogel slab disposed within the groove, said hydrogel slab being chemically configured to vary its displacement volume according to changes in concentration of an analyte in the body fluid, said hydrogel slab being further configured to be detectable by externally-based means for imaging body structures, and wherein under an initial condition the hydrogel slab has a width x0, thickness z0, and length y0, y0 being between about 5 and about 50 times greater than both x0 and y0. - View Dependent Claims (52, 53)
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54. A method of monitoring an analyte in a patient'"'"'s body fluid in situ, comprising the steps of:
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implanting a biosensor chip having a support block formed of rigid or semi-rigid, biocompatible material;
a groove in the support block having one or more openings permitting penetration of a patient'"'"'s body fluid;
a semipermeable membrane configured to permit passage of the analyte and prevent passage of proteins into the groove; and
an analyte sensitive hydrogel slab disposed within the groove, said hydrogel slab being chemically configured to vary its displacement volume according to changes in concentration of an analyte in the body fluid, and said hydrogel slab being further configured to be detectable by externally-based means for imaging body structures in the patient'"'"'s body;
providing means for scanning the hydrogel slab in the biosensor chip implanted within the patient'"'"'s body, and arranging and operating the hydrogel scanning means to detect changes in the displacement volume of the hydrogel. - View Dependent Claims (55, 56, 57, 58, 59)
contacting the sensor chip with a series of solutions having different known concentrations of analyte, storing a value of the displacement volume for each of the solutions, and constructing a calibration curve for translating a measured displacement volume to a corresponding analyte concentration.
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59. The method of claim 58, wherein the analyte is glucose.
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60. A biosensor system comprising:
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an implantable sensor chip including an analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a patient'"'"'s body fluid; and
image scanning means configured to image the hydrogel slab and to quantify changes in the displacement volume. - View Dependent Claims (61, 62, 63, 64, 65, 66, 67, 68)
a quantity of glucose-binding moieties immobilized therein, and a quantity of complementary molecules immobilized therein, said complementary molecules configured to selectively bind to said glucose-binding moieties.
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Specification