Durable hypodermic jet injector apparatus and method

• US 6,752,781 B2
• Filed: 01/25/2002
• Issued: 06/22/2004
• Est. Priority Date: 06/08/2001
• Status: Expired due to Term

• Current Assignee: Bioject Incorporated, Inovio Pharmaceuticals, Inc.
• Original Assignee: Bioject Incorporated
• Inventors: Williamson, Daniel, Landau, Sergio
• Primary Examiner(s): Huson, Gregory L.
• Assistant Examiner(s): WIEKER, AMANDA FLYNN
• Application Number:
  US10/057,052
• Publication Number:
  US 20020188250A1
• Time in Patent Office: 879 Days
• Field of Search: 604/68-72, 604/136, 604/140-145, 604/181-187, 604/207-211, 604/246
• US Class Current: 604/70
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 5/1782 Devices aiding filling of syringes in situ combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31556 Accuracy improving means

Abstract

A gas-powered, durable, needle-less hypodermic jet injection device (10, 210) includes a hand-held injector (12, 212) which receives into an injection cylinder a volume of liquid medication to be injected in the form of a high velocity jet capable of penetrating the skin without the use of a hypodermic needle. The injection device provides an injection orifice, and an injection piston. Forceful movement of the injection piston causes a high velocity injection jet of liquid medication to be expelled from the injection cylinder via the injection orifice. The injection device includes features which improve its usability, particularly for users with hands that are possibly weak, feeble, or arthritic, for example; and also includes additional features which improve manufacturability, durability, and cost effectiveness of the device.

Claims

1. A gas powered hypodermic jet injection device, said device comprising:

a device body having a forward end;

an injection cylinder at the forward end of said device body, and said injection cylinder having a cylinder bore in which an injection piston is sealingly movable to cooperatively define a variable-volume chamber for holding a dose of liquid medication;

said injection cylinder defining a fine-dimension injection orifice in liquid flow communication with said variable-volume chamber to receive and discharge liquid medication as a forceful high velocity jet upon forceful movement of said injection piston in said cylinder;

a power source in said device body for forcefully moving said injection piston in said cylinder in response to communication of gas pressure to a gas pressure piston;

said power source including a source of pressurized gas for selective communication with said gas pressure piston;

a trigger assembly for selectively effecting communication of pressurized gas from said source to said gas pressure piston; and

a lost motion preventing mechanism selectively drivingly connecting said gas pressure piston to said injection piston;

wherein said lost motion prevention mechanism includes said gas pressure piston defining a bore, an injection ram interfacing at a forward end with said injection piston and adjacent to an aft end portion thereof being received into said bore and being selectively associated with said gas pressure piston, and said lost motion prevention mechanism in a first condition selectively allowing relative axial motion of said gas pressure piston and said injection ram, and also said lost motion prevention mechanism in a second condition selectively coupling said injection ram to said gas pressure piston for axial motion in unison therewith.

2. A gas powered hypodermic jet injection device, said device comprising:

a device body having a forward end;

an injection cylinder at the forward end of said device body, and said injection cylinder having a cylinder bore in which an injection piston is sealingly movable to cooperatively define a variable-volume chamber for holding a dose of liquid medication;

said injection cylinder defining a fine-dimension injection orifice in liquid flow communication with said variable-volume chamber to receive and discharge liquid medication as a forceful high velocity jet upon forceful movement of said injection piston in said cylinder;

a power source in said device body for forcefully moving said injection piston in said cylinder in response to communication of gas pressure to a gas pressure piston;

said power source including a source of pressurized gas for selective communication with said gas pressure piston;

a trigger assembly for selectively effecting communication of pressurized gas from said source to said gas pressure piston; and

a lost motion preventing mechanism selectively drivingly connecting said gas pressure piston to said injection piston;

wherein said lost motion prevention mechanism includes said gas pressure piston defining a bore, an injection ram interfacing at a forward end with said injection piston and adjacent to an aft end portion thereof being received into said bore;

a clutching member in a first position allowing said injection ram and said gas pressure piston to move axially independently of one another, and said clutching member in response to a selected event moving to a second position clutching said injection ram and said gas pressure piston for axial movement in unison.

3. The jet injection device of claim 2 wherein said selected event is selected from the group consisting of:

rapid acceleration of said gas pressure piston in response to communication of pressurized gas to said gas pressure piston, and relative axial motion of said gas pressure piston and said injection ram in response to communication of pressurized gas to said gas pressure piston.

4. A gas powered hypodermic jet injection device, said device comprising:

a device body having a forward end;

an injection cylinder at the forward end of said device body, and said injection cylinder having a cylinder bore in which an injection piston is sealingly movable to cooperatively define a variable-volume chamber for holding a dose of liquid medication;

said injection cylinder defining a fine-dimension injection orifice in liquid flow communication with said variable-volume chamber to receive and discharge liquid medication as a forceful high velocity jet upon forceful movement of said injection piston in said cylinder;

a power source in said device body for forcefully moving said injection piston in said cylinder in response to communication of gas pressure to a gas pressure piston;

said power source including a source of pressurized gas for selective communication with said gas pressure piston;

a trigger assembly for selectively effecting communication of pressurized gas from said source to said gas pressure piston; and

a lost motion preventing mechanism selectively drivingly connecting said gas pressure piston to said injection piston;

wherein said trigger assembly includes a trigger sleeve including a pair of substantially identical portions arranged in mirror image relationship to one another, said pair of substantially identical portions each defining an axially extending recess, and the axially extending recesses of each of said pair of substantially identical portions cooperatively defining a blind axially extending recess, said trigger sleeve carrying a pair of seal elements in axially spaced apart relation within said blind axially extending recess, and a central member disposed within said blind recess and between said pair of seal elements and sealingly associating with each of said substantially identical portions, said central portion defining a bore providing an axial flow path for pressurized gas from said source to said gas pressure piston.

5. The jet injection device of claim 4 wherein said injection device includes a stem member slidably carrying said trigger sleeve, and said stem member further defines a pair of axially extending bores aligned with one another and extending from opposite ends of said stem member toward but short of one another but not communicating internally of said stem member, said stem member also defining at least one cross bore extending outwardly from each of said pair of axially extending bores to open outwardly on an outer surface of said stem member there to define a respective one of a pair of ports.

6. The jet injection device of claim 5 wherein in response to sliding motion of said trigger sleeve along said stem between a first position and a second position said pair of seal members move from a respective first orientation in which said pair of seal members straddle a single one of said pair of ports, and to a second orientation in which said pair of seal members straddle both of said pair of ports and pressurized gas communicates within said central member therebetween.

7. A gas powered hypodermic jet injection device, said device comprising:

a device body having a forward end;

an injection cylinder at the forward end of said device body, and said injection cylinder having a cylinder bore in which an injection piston is sealingly movable to cooperatively define a variable-volume chamber for holding a dose of liquid medication;

said injection cylinder defining a fine-dimension injection orifice in liquid flow communication with said variable-volume chamber to receive and discharge liquid medication as a forceful high velocity jet upon forceful movement of said injection piston in said cylinder;

a power source in said device body for forcefully moving said injection piston in said cylinder in response to communication of gas pressure to a gas pressure piston;

said power source including a source of pressurized gas for selective communication with said gas pressure piston;

a trigger assembly for selectively effecting communication of pressurized gas from said source to said gas pressure piston; and

said device body defining an axially elongate recess opening along a side thereof, a door member in a first position closing said recess, and said door member opening to a second position to reveal said recess and a penetrator member disposed within said recess, said recess being sized and configured to accept a pressurized gas capsule including a penetrable diaphragm portion and an end surface opposite to said penetrable diaphragm portion, said door member including a camming surface engaging said end surface, and in response to closing of said door member from said second position to said first position said camming surface moving said pressurized gas capsule fully into said recess and impaling said pressurized gas capsule at said penetrable diaphragm portion upon said penetrator member.

8. A The jet injection device of claim 7 wherein said door member further includes a reentrant portion in said first position of said door closing a portion of said recess, and in said second position of said door member said reentrant portion protruding into said recess to support said gas pressure capsule in a relatively angulated position relative to an axis of said injection device, whereby, after closing of said door member to said second position and penetration of said pressurized gas capsule reopening of said door member to said second position forces said pressurized gas capsule once again to a relatively angulated position relative to said axis of said injection device and partially out of said recess so that said gas capsule is dislodged at said diaphragm portion from said penetrator member.

9. A gas powered hypodermic jet injection device, said device comprising:

a device body having a forward end;

an injection cylinder at the forward end of said device body, and said injection cylinder having a cylinder bore in which an injection piston is sealingly movable to cooperatively define a variable-volume chamber for holding a dose of liquid medication;

said injection cylinder defining a fine-dimension injection orifice in liquid flow communication with said variable-volume chamber to receive and discharge liquid medication as a forceful high velocity jet upon forceful movement of said injection piston in said cylinder;

said injection piston abutting a movable ram member having an elongate gear rack section formed along a side thereof, a thumb wheel rotationally carried by said injection device body, and said thumb wheel including a pair of laterally spaced apart wheel portions each defining a peripheral tactile surface, and a pinion gear member disposed between said pair of wheel portions and drivingly connecting therewith, said pinion gear member drivingly engaging with said gear rack section on said ram member.

10. A method of operating a gas powered hypodermic jet injection device, said method comprising steps of:

providing a device body having a forward end;

providing an injection cylinder at the forward end of said device body, and providing said injection cylinder with a cylinder bore in which an injection piston is sealingly movable, utilizing said injection piston and said injection cylinder to cooperatively define a first variable-volume chamber for holding a dose of liquid medication;

providing for said injection cylinder to define a fine-dimension injection orifice in liquid flow communication with said first variable-volume chamber to receive and discharge liquid medication as a forceful high velocity jet upon forceful movement of said injection piston in said injection cylinder;

providing a power source in said device body for forcefully moving said injection piston in said injection cylinder in response to communication of gas pressure to a second variable-volume chamber in which a gas pressure piston is sealingly movable;

said power source including a source of pressurized gas for selective communication with said gas pressure piston;

providing a trigger assembly for selectively effecting communication of pressurized gas from said source to said gas pressure piston; and

providing a volume minimizing mechanism variably connecting said injection piston and said gas pressure piston so that said second variable-volume chamber defines a minimum volume when pressurized gas begins communication to said gas pressure piston.

11. The method of claim 10 including the step on including in said volume minimization mechanism a clutching member which in response to a limited axial relative movement of said gas pressure piston and said injection piston drivingly engages said injection piston and said gas pressure piston to thereafter move axially in unison.

12. A method of providing a gas powered hypodermic jet injection device, said method comprising steps of:

providing a device body having a forward end;

providing an injection cylinder at the forward end of said device body, disposing sealingly in said injection cylinder an injection piston to cooperatively define a variable-volume chamber for holding a dose of liquid medication;

providing said injection cylinder with a fine-dimension injection orifice in liquid flow communication with said variable-volume chamber, and utilizing said injection orifice to receive and discharge liquid medication as a forceful high velocity jet upon forceful movement of said injection piston in said injection cylinder;

providing a power source in said device body for forcefully moving said injection piston in said cylinder in response to communication of gas pressure to a gas pressure piston;

providing for said power source to include a source of pressurized gas for selective communication with said gas pressure piston;

providing a trigger assembly for selectively effecting communication of pressurized gas from said source to said gas pressure piston; and

configuring said device body to define an axially elongate recess opening along a side thereof, providing a door member in a first position closing said recess and said door member opening to a second position to reveal said recess and a penetrator member disposed within said recess;

providing for said recess to be sized and configured to accept a pressurized gas capsule including a penetrable diaphragm portion and an end surface opposite to said penetrable diaphragm portion;

including on said door member a camming surface engaging said end surface, and in response to closing of said door member from said second position to said first position utilizing said camming surface to move said pressurized gas capsule fully into said recess and to be impaled at said penetrable diaphragm portion upon said penetrator member.

13. The method of claim 12 where in said door member is further provided with a reentrant portion, said reentrant portion in said first position of said door closing a portion of said recess, and utilizing said reentrant portion in said second position of said door member to protrude into said recess to support said gas pressure capsule in a relatively angulated position relative to an axis of said injection device;

and after closing of said door member to said second position and penetration of said pressurized gas capsule utilizing said reentrant portion upon reopening of said door member to said second position to force said pressurized gas capsule once again to a relatively angulated position relative to said axis of said injection device, and utilizing said movement of said gas capsule to said relatively angulated position to dislodged said gs capsule at said diaphragm portion from said penetrator member.

14. A method of providing for convenient filling of a gas powered hypodermic jet injection device, said method comprising steps of:

providing said injection device with a device body having a forward end;

providing an injection cylinder at the forward end of said device body, and providing for said injection cylinder to define a cylinder bore in which an injection piston is sealingly movable to cooperatively define a variable-volume chamber for holding a dose of liquid medication;

providing for said injection cylinder to define a fine-dimension injection orifice in liquid flow communication with said variable-volume chamber, and utilizing said injection orifice to receive and discharge liquid medication as a forceful high velocity jet upon forceful movement of said injection piston in said cylinder;

providing for said injection piston to abut a movable ram member, and configuring said movable ram member to have an elongate gear rack section formed along a side thereof, providing a thumb wheel rotationally carried by said injection device body; and

configuring said thumb wheel to include a pair of laterally spaced apart wheel portions each defining a peripheral tactile surface, and providing a pinion gear member disposed between said pair of wheel portions and drivingly connecting therewith, and drivingly engaging said pinion gear member with said gear rack section on said ram member so that manual rotation of said thumb wheel portions is effective to retract said ram member along with said injection piston within said injection cylinder.