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Target analyte detection using asymmetrical self-assembled monolayers

  • US 6,753,143 B2
  • Filed: 05/01/2001
  • Issued: 06/22/2004
  • Est. Priority Date: 05/01/2000
  • Status: Expired due to Term
First Claim
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1. A composition comprising a metallic surface, said surface comprising:

  • a) a self-assembled monolayer (SAM) forming species comprising a capture probe, wherein said capture probe comprises a nucleic acid; and

    , b) an asymmetric monolayer forming species having the formula;

    embedded imagewhereinA is an attachment linker moiety selected from the group consisting of sulfur and phosphonate;

    MFS is a monolayer forming species selected from the group consisting of conductive oligomers and insulators;

    AG is an electroconduit forming species and, wherein MFS and AG are different.

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