Method of using metaloporphyrins for treatment of arteriosclerotic lesions
First Claim
1. A method of screening and treatment of arteriosclerotic disease, said method comprising the steps of:
- introducing a complexed compound to a patient for cell uptake of the compound, the compound comprising a first portion which includes a photosensitive component, and a second portion comprising a radioactive marker;
conducting tomographic scanning of the patient to determine whether targeted cells in the patient have demonstrated an affinity for the photosensitive compound thereby indicating the presence of plaque buildup;
proportional to arteriosclerotic disease; and
conducting radiation therapy by the second portion of the compound which results in selective ionizing radiation exposure.
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Abstract
A method for diagnosis and treatment of arteriosclerotic lesions is provided wherein the method is characterized by introducing a chemical compound to the patient, the compound being a complex of a photosensitive portion, and a radioactive portion. Cells which exhibit an affinity for the porphyrin element indicate sites of plaque buildup. The radioactive portion within the compound allows tomographic scanning as well as simultaneous radiation treatment. The complexed compound can be introduced to the patient a desired number of times to provide the necessary radiation treatment and ongoing monitoring of plaque removal. Further observation or treatment may be conducted through a fluorescence guided endoscopic procedure.
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Citations
25 Claims
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1. A method of screening and treatment of arteriosclerotic disease, said method comprising the steps of:
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introducing a complexed compound to a patient for cell uptake of the compound, the compound comprising a first portion which includes a photosensitive component, and a second portion comprising a radioactive marker;
conducting tomographic scanning of the patient to determine whether targeted cells in the patient have demonstrated an affinity for the photosensitive compound thereby indicating the presence of plaque buildup;
proportional to arteriosclerotic disease; and
conducting radiation therapy by the second portion of the compound which results in selective ionizing radiation exposure. - View Dependent Claims (2, 3, 4, 5, 6, 7)
said first portion of said compound is selected from the group consisting of 5-ALA, protoporphyrin IX, TCPP, hematoporphyrin derivative;
photofrin, uroporphyrin, coproporphyrin, TPPS, and TMPP; and
said second portion of said compound is selected from the group consisting of radioisotopes of copper which may be complexed with said first portion.
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3. A method, as claimed in claim 2, wherein said radioisotope of copper is 67Cu.
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4. A method, as claimed in claim 1, further comprising the step of:
selecting the type of radioactive marker to match a type of radiation treatment best suited for treatment of a disease.
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5. A method, as claimed in claim 1, further comprising the step of:
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introducing the complexed compound again to the patient to achieve further radiation therapy; and
conducting tomographic scanning to view treatment results.
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6. A method, as claimed in claim 1, further comprising the step of:
introducing the complexed compound wherein the second portion is selectively dosed to deliver a desired amount of radiation.
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7. A method, as claimed in claim 6, further including the step of adjusting the type and dosage of the second portion to provide effective therapy.
- 8. A radiopharmaceutical composition for the visualization, diagnosis or treatment of arteriosclerosis comprising a porphyrin complexing a radiation-emitting metal and a pharmaceutical excipient.
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11. A method of visualizing an arteriosclerotic region in an individual comprising:
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(a) administering a radiopharmaceutical comprising a porphyrin complexing a gamma radiation-emitting metal to an individual, and (b) detecting the gamma radiation emitted from within the individual to create an image of an arteriosclerotic region within the individual. - View Dependent Claims (12, 13, 14, 15)
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16. A method of diagnosing arteriosclerosis in an individual comprising:
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(a) administering a radiopharmaceutical comprising a porphyrin complexing a gamma radiation-emitting metal to an individual, (b) detecting the gamma radiation emitted from within the individual, and (c) comparing the detected gamma radiation reading from the individual with reference readings wherein comparison to reference readings is indicative of the presence of arteriosclerosis in an individual. - View Dependent Claims (17, 18, 19, 20)
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- 21. A method of treating arteriosclerosis in an individual comprising administering a therapeutically-effective amount of a radiopharmaceutical comprising a porphyrin complexing a radiation-emitting metal to an individual.
Specification