Collagen or collagen-like peptide containing polymeric matrices

• US 6,753,311 B2
• Filed: 06/28/2001
• Issued: 06/22/2004
• Est. Priority Date: 06/23/2000
• Status: Expired due to Fees

• Current Assignee: Drexel University
• Original Assignee: Drexel University
• Inventors: Ko, Frank, Fertala, Andrzej
• Primary Examiner(s): Witz, Jean C.
• Application Number:
  US09/895,674
• Publication Number:
  US 20030021821A1
• Time in Patent Office: 1,090 Days
• Field of Search: 514/2, 514/21
• US Class Current: 514/17.2
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

Tissue engineering scaffolds comprising collagen or a collagen-like peptides incorporated within or between polymeric fibers and methods for their production are provided.

Claims

1. A tissue engineering scaffold comprising collagen or a collagen-like peptide incorporated within polymeric fiber matrix.

2. The tissue engineering scaffold of claim 1 wherein the collagen is collagen II.

3. The tissue engineering scaffold of claim 1 wherein the collagen-like peptide comprises amino acids 703 to 936 of collagen II.

4. A tissue engineering scaffold comprising a collagen-like peptide consisting of SEQ ID NO:

1.