Method and apparatus for filling or refilling a needle-less injector

• US 6,755,220 B2
• Filed: 04/25/2002
• Issued: 06/29/2004
• Est. Priority Date: 04/27/2001
• Status: Expired due to Fees

• Current Assignee: PenJet Corp.
• Original Assignee: PenJet Corp.
• Inventors: Levy, Seth D., Wise, Roger R., Castellano, Thomas P.
• Primary Examiner(s): JACYNA, J CASIMER
• Application Number:
  US10/134,511
• Publication Number:
  US 20020161334A1
• Time in Patent Office: 796 Days
• Field of Search: 141/2, 141/18, 141/21, 141/25-27, 141/383, 604/68-72
• US Class Current: 141/27
• CPC Class Codes: A61J 1/2044 having slits
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

Devices and methods are described for filling or refilling a needle-less injector. A coupling device is attached to a vessel, and mated to the dispensing end of a needle-less injector. A volume of fluid may be transferred via the coupling device, from the vessel to the injector. Air may be removed from the injector prior to the injector, vessel, and coupling device being separated from one another. In alternate embodiments, the vessel may include filling equipment capable of filling or refilling multiple needle-less injectors simultaneously, in series, or both. In other embodiments, a coupling device may be used to withdraw a fluid from a storage vial into a vessel for filling a needle-less injector. A storage vial may alternately contain a product, and a fluid may be introduced therein via a coupling device to create a mixture, which may be subsequently withdrawn into a vessel for filling a needle-less injector.

Claims

1. A coupling device to fill a needle-less injector comprising:

a contact surface configured to mate non-frangibly with a receiving surface of a needle-less injector;

an orifice disposed upon said contact surface;

a vessel end configured to affix said coupling device to a vessel; and

an unobstructed channel to provide fluid communication between said orifice and said vessel end,

wherein said coupling device is asymmetrical across a plane perpendicular to an axis of said unobstructed channel.

2. The coupling device of claim 1, further comprising an injector attachment mechanism to attach said coupling device to said needle-less injector.

3. The coupling device of claim 2, wherein said injector attachment mechanism further includes an attachment fitting selected from the group consisting of a screw threading, a snap fitting, and a pressure fitting.

4. The coupling device of claim 2, wherein said injector attachment mechanism includes a screw threading.

5. The coupling device of claim 2, wherein said injector attachment mechanism further includes grips.

6. The coupling device of claim 1, wherein said vessel is a Luer syringe.

7. The coupling device of claim 1, further comprising a vessel attachment mechanism to attach said coupling device to a vessel.

8. The coupling device of claim 7, wherein said vessel attachment mechanism is selected from the group consisting of at least one elevated tab, a screw threading, a snap fitting, and a pressure fitting.

9. The coupling device of claim 8, further including a vessel attachment receiving mechanism.

10. The coupling device of claim 9, wherein said vessel is a Luer syringe, said vessel attachment mechanism is two elevated tabs, and said vessel attachment receiving mechanism is an interior screw threading that cooperates with said two elevated tabs.

11. The coupling device of claim 1, wherein said channel further includes a cylindrical segment.

12. The coupling device of claim 11, wherein said channel further includes a conical segment disposed between said cylindrical segment and said orifice.

13. The coupling device of claim 1, wherein said orifice includes a diameter smaller than a diameter of a dispensing orifice disposed upon said receiving surface.

14. The coupling device of claim 1, wherein said vessel is filling equipment.

15. The coupling device of claim 14, wherein said filling equipment further includes a reservoir configured to contain a fluid.

16. The coupling device of claim 14, wherein said filling equipment further includes a conduit to provide fluid communication between said coupling device and said filling equipment.

17. The coupling device of claim 16, wherein said filling equipment further includes an adapter to connect said conduit to said coupling device.

18. The coupling device of claim 14, wherein said filling equipment is configured to fill multiple needle-less injectors.

19. The coupling device of claim 14, wherein said coupling device is configured to be sequentially mated to a series of needle-less injectors.

20. The coupling device of claim 14, further including at least two coupling devices.

21. The coupling device of claim 20, wherein said at least two coupling devices are configured to be simultaneously mated to a group of needle-less injectors.

22. The coupling device of claim 21, wherein said at least two coupling devices are configured to be sequentially mated to a series of said groups of needle-less injectors.

23. A coupling device to fill a needle-less injector comprising:

a contact surface configured to mate with a receiving surface of a needle-less injector;

an orifice disposed upon said contact surface;

a vessel end configured to affix said coupling device to a vessel; and

a channel to provide fluid communication between said orifice and said vessel end,

wherein said channel further includes a cylindrical segment,

wherein said channel further includes a conical segment disposed between said cylindrical segment and said orifice, and

wherein said cylindrical segment is configured to matingly receive a Luer syringe.

24. The coupling device of claim 23, wherein said cylindrical segment further includes:

a segment of large diameter; and

a segment of small diameter configured between said segment of large diameter and said conical segment.

25. The coupling device of claim 24, wherein said cylindrical segment further includes a shoulder configured between said segment of large diameter and said segment of small diameter, said shoulder being configured at an angle similar to an angle of a tip of a protruding tube of said Luer syringe.

26. A coupling device to fill a needle-less injector comprising:

a contact surface configured to mate with a receiving surface of a needle-less injector;

an orifice disposed upon said contact surface;

a vessel end configured to affix said coupling device to a vessel;

a channel to provide fluid communication between said orifice and said vessel end; and

an injector attachment mechanism to attach said coupling device to said needle-less injector,

wherein said injector attachment mechanism is configured to attach said coupling device to a storage vial.

27. A filling device to fill a needle-less injector comprising:

a vessel to contain a fluid and including a protruding tube; and

a coupling device including;

a contact surface configured to mate non-frangibly with a receiving surface of a needle-less injector;

an orifice disposed upon said contact surface; and

a channel to provide fluid communication between said orifice and said vessel, said protruding tube residing at least partially within said channel,

wherein said filling device is asymmetrical across a plane perpendicular to an axis of said channel.

28. The filling device of claim 27, further comprising an injector attachment mechanism to attach said filling device to said needle-less injector.

29. The filling device of claim 28, wherein said injector attachment mechanism further includes an attachment fitting selected from the group consisting of a screw threading, a snap fitting, and a pressure fitting.

30. The filling device of claim 28, wherein said injector attachment mechanism includes a screw threading.

31. The filling device of claim 28, wherein said injector attachment mechanism further includes grips.

32. The filling device of claim 27, wherein said vessel is a Luer syringe.

33. The filling device of claim 27, further comprising a vessel attachment mechanism to attach said coupling device to said vessel.

34. The filling device of claim 33, wherein said vessel attachment mechanism is selected from the group consisting of at least one elevated tab, a screw threading, a snap fitting, and a pressure fitting.

35. The filling device of claim 34, further including a vessel attachment receiving mechanism.

36. The filling device of claim 35, wherein said vessel is a Luer syringe, said vessel attachment mechanism is two elevated tabs, and said vessel attachment receiving mechanism is an interior screw threading that cooperates with said two elevated tabs.

37. The filling device of claim 27, wherein said channel further includes a cylindrical segment.

38. The filling device of claim 37, wherein said channel further includes a conical segment disposed between said cylindrical segment and said orifice.

39. A filling device to fill a needle-less injector comprising:

a vessel to contain a fluid and including a protruding tube; and

a coupling device including;

a contact surface configured to mate with a receiving surface of a needle-less injector;

an orifice disposed upon said contact surface; and

a channel to provide fluid communication between said orifice and said vessel, said protruding tube residing at least partially within said channel,

wherein said channel further includes a cylindrical segment,

wherein said channel further includes a conical segment disposed between said cylindrical segment and said orifice, and

wherein said cylindrical segment is configured to matingly receive a Luer syringe.

40. The filling device of claim 39, wherein said cylindrical segment further includes:

a segment of large diameter; and

a segment of small diameter configured between said segment of large diameter and said conical segment.

41. The filling device of claim 40, wherein said cylindrical segment further includes a shoulder configured between said segment of large diameter and said segment of small diameter, said shoulder being configured at an angle similar to an angle of a tip of a protruding tube of said Luer syringe.

42. A filling device to fill a needle-less injector comprising:

a vessel to contain a fluid and including a protruding tube; and

a coupling device including;

a contact surface configured to mate with a receiving surface of a needle-less injector;

an orifice disposed upon said contact surface; and

a channel to provide fluid communication between said orifice and said vessel, said protruding tube residing at least partially within said channel,

wherein said orifice includes a diameter smaller than a diameter of a dispensing orifice disposed upon said receiving surface.

43. A filling device to fill a needle-less injector comprising:

a vessel to contain a fluid and including a protruding tube; and

a coupling device including;

a contact surface configured to mate with a receiving surface of a needle-less injector;

an orifice disposed upon said contact surface;

a channel to provide fluid communication between said orifice and said vessel, said protruding tube residing at least partially within said channel; and

an injector attachment mechanism to attach said filling device to said needle-less injector,

wherein said injector attachment mechanism is configured to attach said filling device to a storage vial.

44. In combination, a needle-less injector and a coupling device configured to fill said needle-less injector, said combination comprising:

said needle-less injector; and

said coupling device, said coupling device being mated non-frangibly to said needle-less injector, and further including;

a contact surface configured to mate with a receiving surface of said needle-less injector;

an orifice disposed upon said contact surface;

a vessel end configured to affix said coupling device to a vessel; and

an unobstructed channel to provide fluid communication between said orifice and said vessel end.

45. The combination of claim 44, further comprising an injector attachment mechanism to attach said coupling device to said needle-less injector.

46. The combination of claim 45, wherein said injector attachment mechanism further includes an attachment fitting selected from the group consisting of a screw threading, a snap fitting, and a pressure fitting.

47. The combination of claim 45, wherein said attachment mechanism includes a screw threading.

48. The combination of claim 45, wherein said injector attachment mechanism further includes grips.

49. The combination of claim 44, wherein said vessel is a Luer syringe.

50. The combination of claim 44, further comprising a vessel attachment mechanism configured to attach said coupling device to a vessel.

51. The combination of claim 50, wherein said vessel attachment mechanism is selected from the group consisting of at least one elevated tab, a screw threading, a snap fitting, and a pressure fitting.

52. The combination of claim 51, wherein said vessel attachment mechanism is two elevated tabs.

53. The combination of claim 45, wherein said channel further includes a cylindrical segment.

54. The combination of claim 53, wherein said channel further includes a conical segment disposed between said cylindrical segment and said orifice.

55. The combination of claim 54, wherein said cylindrical segment further includes:

a segment of large diameter; and

a segment of small diameter configured between said segment of large diameter and said conical segment.

56. The combination of claim 55, wherein said cylindrical segment further includes a shoulder configured between said segment of large diameter and said segment of small diameter, said shoulder being configured at an angle similar to an angle of a tip of a protruding tube of said Luer syringe.

57. The combination of claim 44, wherein said orifice includes a diameter smaller than a diameter of a dispensing orifice disposed upon said receiving surface.

58. The combination of claim 44, wherein said vessel is filling equipment.

59. In combination, a needle-less injector and a coupling device configured to fill said needle-less injector, said combination comprising:

said needle-less injector; and

said coupling device, said coupling device being mated to said needle-less injector, and further including;

a contact surface configured to mate with a receiving surface of said needle-less injector;

an orifice disposed upon said contact surface;

a vessel end configured to affix said coupling device to a vessel;

a channel to provide fluid communication between said orifice and said vessel end; and

an injector attachment mechanism to attach said coupling device to said needle-less injector,

wherein said channel further includes a cylindrical segment,

wherein said channel further includes a conical segment disposed between said cylindrical segment and said orifice, and

wherein said cylindrical segment is configured to matingly receive a Luer syringe.

60. A method of filling a needle-less injector, said method comprising:

providing a coupling device comprising;

a contact surface configured to mate non-frangibly with a receiving surface of a needle-less injector,

an orifice disposed upon said contact surface,

a vessel end configured to affix said coupling device to a vessel, and

an unobstructed channel to provide fluid communication between said orifice and said vessel end,

wherein said coupling device is asymmetrical across a plane perpendicular to an axis of said unobstructed channel;

mating said coupling device at said vessel end to a vessel;

mating said coupling device at said contact surface to a needle-less injector, to provide fluid communication between said needle-less injector and said vessel; and

dispensing a volume of fluid from said vessel to said needle-less injector.

61. The method of claim 60, wherein mating said vessel to said coupling device comprises screwing said vessel and said coupling device together.

62. The method of claim 60, wherein mating said needle-less injector to said coupling device comprises holding said contact surface against a receiving surface disposed upon said needle-less injector.

63. The method of claim 60, wherein mating said needle-less injector to said coupling device comprises attaching said needle-less injector to said coupling device.

64. The method of claim 63, wherein attaching said needle-less injector to said coupling device comprises screwing said needle-less injector and an injector attachment mechanism configured upon said coupling device together.

65. The method of claim 60, wherein said needle-less injector is void of fluid prior to dispensing said volume of said fluid from said vessel.

66. The method of claim 60, wherein said needle-less injector is at least partially filled with a latent fluid, a lyophilized solid, a non-lyophilized solid, or another product prior to dispensing said volume of said fluid from said vessel.

67. The method of claim 60, wherein dispensing said volume of said fluid from said vessel comprises depressing a plunger operably attached to said vessel.

68. The method of claim 60, further including removing air from said needle-less injector.

69. The method of claim 68, wherein removing said air comprises pulling back on a plunger operably attached to said vessel.

70. The method of claim 60, further including measuring said volume of said fluid dispensed from said vessel into said needle-less injector by comparing a level of said fluid in said vessel with graduations disposed upon said vessel.

71. The method of claim 60, further including removing a cap from said needle-less injector prior to mating said coupling device to said needle-less injector.

72. The method of claim 60, wherein said vessel is filling equipment.

73. The method of claim 60, further including separating said coupling device from said vessel and said needle-less injector after dispensing said volume of said fluid from said vessel.

74. The method of claim 73, wherein separating said vessel from said coupling device further includes unscrewing said vessel from said coupling device.

75. The method of claim 73, further including screwing a cap onto said needle-less injector after separating said coupling device from said needle-less injector.

76. The method of claim 60, wherein prior to mating said coupling device at said second end thereof to said needle-less injector, said method further includes:

mating said coupling device at said second end thereof to a storage vial, to provide fluid communication between said storage vial and said vessel;

withdrawing a volume of fluid from said storage vial to said vessel; and

separating said coupling device from said storage vial.

77. The method of claim 76, wherein mating said coupling device to said storage vial comprises attaching said coupling device to said storage vial.

78. The method of claim 77, wherein attaching said coupling device to said storage vial comprises screwing said storage vial and an attachment mechanism configured upon said coupling device together.

79. The method of claim 76, wherein said vessel is void of fluid prior to withdrawing said volume of said fluid from said storage vial to said vessel.

80. The method of claim 76, wherein said vessel is at least partially filled with a latent fluid, a lyophilized solid, a non-lyophilized solid, or another product prior to withdrawing said volume of said fluid from said storage vial to said vessel.

81. The method of claim 76, wherein withdrawing said volume of said fluid from said storage vial to said vessel comprises pulling back on a plunger operably attached to said vessel.

82. The method of claim 76, wherein prior to withdrawing said volume of fluid from said storage vial to said vessel, said method further includes:

dispensing a volume of fluid from said vessel to said storage vial; and

mixing said volume of fluid with a product contained in said storage vial to create a mixture.

83. The method of claim 82, wherein withdrawing said volume of said fluid from said storage vial to said vessel comprises withdrawing a volume of said mixture from said storage vial to said vessel, and dispensing said volume of said fluid from said vessel to said needle-less injector comprises dispensing a volume of said mixture from said vessel to said needle-less injector.

84. The method of claim 82, wherein mixing said volume of said fluid with said product contained in said storage vial to create said mixture comprises agitating said storage vial.

85. The method of claim 82, further including shuffling said mixture between said vessel and said storage vial to blend said mixture.

86. The method of claim 76, further including removing a cap from said storage vial prior to mating said storage vial to said coupling device.

87. In combination, a storage vial and a coupling device configured to transfer a fluid, a mixture, or both between said storage vial and a vessel, said combination comprising:

said storage vial; and

said coupling device, said coupling device being mated to said storage vial, and further including;

a contact surface configured to mate with an exterior of said storage vial, and also configured to mate non-frangibly with a receiving surface of a needle-less injector,

an orifice disposed upon said contact surface,

a vessel end configured to affix said coupling device to a vessel, and

an unobstructed channel to provide fluid communication between said orifice and said vessel end,

wherein said coupling device is asymmetrical across a plane perpendicular to an axis of said unobstructed channel.

88. The combination of claim 87, further comprising an attachment mechanism to attach said coupling device to said storage vial.

89. The combination of claim 88, wherein said attachment mechanism further includes an attachment fitting selected from the group consisting of a screw threading, a snap fitting, and a pressure fitting.

90. The combination of claim 88, wherein said attachment mechanism includes a screw threading.

91. The combination of claim 90, wherein said attachment mechanism further includes grips.

92. The combination of claim 87, wherein said channel further includes a cylindrical segment.

93. The combination of claim 92, wherein said channel further includes a conical segment disposed between said cylindrical segment and said orifice.

94. The combination of claim 87, wherein said vessel is filling equipment.