Method for delivering energy to tissue and apparatus

• US 6,755,849 B1
• Filed: 03/28/2002
• Issued: 06/29/2004
• Est. Priority Date: 03/28/2002
• Status: Active Grant

• Current Assignee: BioTex Incorporated, Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: BioTex Incorporated, Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Pasricha, Pankaj J., Gowda, Ashok, McNichols, Roger J., Motamedi, Massoud
• Primary Examiner(s): Leubecker, John P.
• Assistant Examiner(s): Johnson, III, Henry M.
• Application Number:
  US10/109,540
• Time in Patent Office: 824 Days
• Field of Search: 607/88, 607/89, 607/92, 607/93, 604/96.01, 604/103.06, 606/2, 606/13
• US Class Current: 607/89
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light

Abstract

Disclosed is a method for delivering energy to a tissue. The method includes providing an apparatus which includes an energy delivery component and an inflatable member disposed around the energy delivery component. At a minimum, the inflatable member is constructed of a flexible inner wall and a flexible outer wall, which, taken together, enclose a cavity therebetween. The inflatable member is expanded such that the inflatable member'"'"'s outer wall contacts the tissue'"'"'s surface. Cooling fluid is disposed in the cavity, and energy is delivered to the energy delivery component so that at least a portion of the energy delivered to the energy delivery component passes through the inflatable member'"'"'s inner wall, through the cooling fluid disposed in the cavity, through the inflatable member'"'"'s outer wall, and into the tissue. Various apparatus suitable for use in delivering energy to tissues are also disclosed, as is a method for treating GERD or otherwise reducing reflux of a subject'"'"'s stomach contents into the subject'"'"'s esophagus.

Claims

1. A method for delivering energy to a tissue having a tissue surface, said method comprising:

providing an apparatus comprising an energy delivery component and an inflatable member disposed around the energy delivery component, wherein the inflatable member comprises an inner wall and an outer wall, wherein the inflatable member'"'"'s inner wall is flexible, wherein the inflatable member'"'"'s outer wall is flexible, and wherein the inflatable member'"'"'s inner wall and the inflatable member'"'"'s outer wall enclose a cavity therebetween;

expanding the inflatable member such that the inflatable member'"'"'s outer wall contacts the tissue surface;

disposing a cooling fluid in the cavity; and

delivering energy to the energy delivery component so that at least a portion of the energy delivered to the energy delivery component passes through the inflatable member'"'"'s inner wall, through the cooling fluid disposed in the cavity, through the inflatable member'"'"'s outer wall, and into the tissue, wherein said disposing a cooling fluid in the cavity is carried out by circulating the cooling fluid through the cavity during said delivering and wherein the cooling fluid, prior to or subsequent to being circulated through the cavity, is contacted with the energy delivery component under conditions effective to cool the energy delivery component.

2. A method for delivering energy to a tissue having a tissue surface, said method comprising:

providing an apparatus comprising an energy delivery component and an inflatable member disposed around the energy delivery component, wherein the inflatable member comprises an inner wall and an outer wall, wherein the inflatable member'"'"'s inner wall is flexible, wherein the inflatable member'"'"'s outer wall is flexible, and wherein the inflatable member'"'"'s inner wall and the inflatable member'"'"'s outer wall enclose a cavity therebetween;

expanding the inflatable member such that the inflatable member'"'"'s outer wall contacts the tissue surface;

disposing a cooling fluid in the cavity; and

delivering energy to the energy delivery component so that at least a portion of the energy delivered to the energy delivery component passes through the inflatable member'"'"'s inner wall, through the cooling fluid disposed in the cavity, through the inflatable member'"'"'s outer wall, and into the tissue, wherein the tissue comprises a surface tissue layer and one or more subsurface tissue layers lying beneath the surface tissue layer, wherein said delivering is carried out under conditions effective to produce a lesion in at least a portion of at least one of the one or more subsurface tissue layers, and wherein the lesion is substantially confined to the one or more subsurface tissue layers.

3. An apparatus comprising:

an energy delivery component; and

an inflatable member disposed around said energy delivery component, wherein said inflatable member comprises an inner wall and an outer wall;

wherein the inflatable member'"'"'s inner wall and the inflatable member'"'"'s outer wall enclose a cavity therebetween, said cavity comprising an inlet and an outlet;

wherein the inflatable member'"'"'s inner wall is flexible; and

wherein the inflatable member'"'"'s outer wall is flexible and impermeable.

4. An apparatus according to claim 3, further comprising:

a housing comprising a first lumen, wherein said energy delivery component is loosely disposed within the first lumen such that the first lumen and said energy delivery component form a passageway; and

wherein at least one of the cavity'"'"'s inlet and outlet is in fluid communication with the passageway.

5. An apparatus according to claim 3, wherein said energy delivery component is an optical waveguide coupled to a light source.

6. A apparatus according to claim 3, wherein said energy delivery component is an fiber optic coupled to a monochromatic light source.

7. A apparatus according to claim 3, wherein said energy delivery component is an fiber optic coupled to a laser light source.

15. A method for reducing reflux of a subject'"'"'s stomach contents into the subject'"'"'s esophagus, said method comprising:

exposing the subject'"'"'s lower esophageal sphincter to laser radiation under conditions effective to cause cellular necrosis in the subject'"'"'s lower esophageal sphincter wherein said exposing is carried out using an apparatus according to claim 3.

8. An apparatus comprising:

an energy delivery component; and

an inflatable member disposed around said energy delivery component, wherein said inflatable member comprises an inner wall and an outer wall;

wherein the inflatable member'"'"'s inner wall and the inflatable member'"'"'s outer wall enclose a cavity therebetween, said cavity comprising an inlet and an outlet;

wherein the inflatable member'"'"'s inner wall is flexible; and

wherein the inflatable member'"'"'s outer wall is flexible, wherein said apparatus further comprises;

a housing comprising a first lumen and a second lumen, wherein said energy delivery component is loosely disposed within the first lumen such that the first lumen and said energy delivery component form a passageway;

wherein at least one of the cavity'"'"'s inlet and outlet is in fluid communication with the passageway; and

wherein the other of the cavity'"'"'s inlet and outlet is in fluid communication with the second lumen.

9. An apparatus according to claim 8, wherein the second lumen is radially disposed around the first lumen.

10. An apparatus according to claim 8, wherein said energy delivery component is an optical waveguide coupled to a light source.

11. A apparatus according to claim 8, wherein said energy delivery component is an fiber optic coupled to a monochromatic light source.

12. A apparatus according to claim 8, wherein said energy delivery component is an fiber optic coupled to a laser light source.

13. An apparatus comprising:

a housing comprising a first lumen and a second lumen; and

an inflatable member disposed around said housing, wherein said inflatable member comprises an inner wall and an outer wall;

wherein the inflatable member'"'"'s inner wall and the inflatable member'"'"'s outer wall enclose a cavity therebetween, said cavity comprising an inlet and an outlet;

wherein the inflatable member'"'"'s inner wall it flexible;

wherein the inflatable member'"'"'s outer wall is flexible; and

wherein first lumen is in fluid communication with one of the cavity'"'"'s inlet and outlet; and

wherein the second lumen is in fluid communication with the other of the cavity'"'"'s inlet and outlet.

14. An apparatus according to claim 13, wherein the second lumen is radially disposed around the first lumen.

16. A method for delivering energy to a tissue comprising a surface tissue layer and one or more subsurface tissue layers lying beneath the surface tissue layer, said method comprising:

cooling at least the tissue'"'"'s surface tissue layer with a cooling fluid; and

exposing the tissue to laser energy such that the laser energy is preferentially absorbed by at least one of the subsurface tissue layers, wherein said cooling and exposing are carried out by providing an apparatus comprising a laser energy delivery component and an inflatable member disposed around the laser energy delivery component, wherein the inflatable member comprises an inner wall and an outer wall, wherein the inflatable member'"'"'s inner wall is flexible, wherein the inflatable member'"'"'s outer wall is flexible, and wherein the inflatable member'"'"'s inner wall and the inflatable member'"'"'s outer wall enclose a cavity therebetween;

by expanding the inflatable member such that the inflatable member'"'"'s outer wall contacts the tissue'"'"'s surface tissue layer;

by disposing a cooling fluid in the cavity under conditions effective to cool at least the tissue'"'"'s surface tissue layer; and

by delivering laser energy to the laser energy delivery component under conditions effective to expose the tissue to laser energy, said laser energy being selected such that it is preferentially absorbed by at least one of the subsurface tissue layers.

17. A method according to claim 16, wherein the tissue comprises a surface tissue layer, a mucosal layer lying beneath the surface tissue layer, and a muscle layer lying beneath the mucosal layer and wherein the laser energy is selected so as to be preferentially absorbed by the muscle layer.