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Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups

  • US 6,756,037 B2
  • Filed: 03/29/2001
  • Issued: 06/29/2004
  • Est. Priority Date: 03/31/2000
  • Status: Expired due to Fees
First Claim
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1. A compound comprising the formula:

  • embedded imagewherein;

    G is a linear or branched polymer residue;

    Y1 and Y2 are independently O, S, or NR9;

    M1-M3 are independently O, S, or NR10;

    M4 is X or Q;

    wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(═

    Y2);

    B is a residue of an amine-containing moiety or a residue of a hydroxyl-containing moiety;

    R1-10 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-4 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-4 heteroalkyls and substituted C1-4 heteroalkyls;

    a, b, c, d, h, i and n ore each independently zero or a positive integer; and

    e, f and g are each independently a positive integer.

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