Method and substances for diagnosis and therapy of sepsis and sepsis-like systemic infections

• US 6,756,483 B1
• Filed: 05/29/2001
• Issued: 06/29/2004
• Est. Priority Date: 10/15/1998
• Status: Expired due to Term

• Current Assignee: B·R·A·H·M·S GmbH (Thermo Fisher Scientific Incorporated)
• Original Assignee: B.R.A.H.M.S Aktiengesellschaft
• Inventors: Weglöhner, Wolfgang, Struck, Joachim, Bergmann, Andreas
• Primary Examiner(s): MERTZ, PREMA MARIA
• Application Number:
  US09/806,437
• Time in Patent Office: 1,127 Days
• Field of Search: 530/399, 435/69.4, 435/471, 435/325, 435/252.3, 435/254.11, 435/71.1, 435/71.2, 435/320.1
• US Class Current: 530/399
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C07K 14/585 Calcitonins
• CPC Class Codes: G01N 2333/585 Calcitonins
• CPC Class Codes: G01N 33/74 involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Abstract

Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.

Claims

1. An isolated Procalcitonin consisting of the amino acid sequence as set forth in SEQ ID NO. 3.