Method and apparatus for measuring cardiac output

• US 6,758,822 B2
• Filed: 09/05/2001
• Issued: 07/06/2004
• Est. Priority Date: 04/27/1999
• Status: Expired due to Term

• Current Assignee: Salvatore Romano
• Original Assignee: Salvatore Romano
• Inventors: Romano, Salvatore
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US09/947,308
• Publication Number:
  US 20020022785A1
• Time in Patent Office: 1,035 Days
• Field of Search: 600/526, 600/508, 600/481, 600/483, 600/485, 600/486, 600/513
• US Class Current: 600/526
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

Cardiac stroke volume and output are estimated using an arterial pressure signal, which may be obtained either invasively, using a catheter-mounted pressure sensor, or non-invasively, with an external plethysmographic sensor mounted with a finger cuff. Both pulsatile and non-pulsatile (continuous) components of the sensed pressure signal are analyzed. Stroke volume is estimated as a function of the ratio between the area under the entire pressure curve and a linear combination of various components of impedance. Depending on the embodiment, first and/or second time derivatives of the pressure signal are used to determine the impedance components. The estimated stroke volume is preferably corrected based on the amount of deviation from a reference pressure of the mean pressure, which itself is determined from the sensed pressure signal. The invention is thus able to estimate stroke volume and cardiac output from the pressure signal alone, with no need for calibration using other highly invasive techniques.

Claims

1. A method for measuring cardiac output (CO) of a patient, comprising the following steps:

sensing arterial blood pressure and converting the sensed arterial blood pressure to a pressure signal;

calculating an estimate of stroke volume as a function only of selected characteristics of the sensed pressure signal, including calculating an area (A) under the entire pressure signal including both pulsatile and non-pulsatile portions of the pressure signal; and

calculating an estimate of CO as a function of the estimated stroke volume and a current heart rate value.

2. A method as in claim 1, in which the step of calculating the estimate of stroke volume comprises the following sub-steps:

estimating selected impedance values from the pressure signal; and

calculating the estimate of stroke volume as a function of a ratio between the calculated area and the estimated selected impedance values.

3. A method as in claim 1, in which the step of calculating the estimate of stroke volume further comprises the following sub-steps:

calculating a mean pressure value of the pressure signal; and

correcting the estimated stroke volume as a predetermined function of the mean pressure value and of a reference pressure.

4. A method as in claim 1, further including the following steps:

detecting times and corresponding pressure values of a systolic peak and of a dicrotic notch in the pressure signal;

evaluating a second derivative of the pressure signal between the systolic peak and the dicrotic notch;

detecting the time and corresponding pressure value of at least one intermediate point in the pressure signal between the systolic peak and the dicrotic notch at which the second derivative has an extreme value; and

estimating at least one of the selected impedance values as a predetermined function of the time and corresponding pressure value of the intermediate point.

5. A method as in claim 1, further including the following steps:

detecting a systolic peak pressure Psys, a diastolic pressure Pdia, and a dicrotic pressure Pdic; and

scaling the estimated stroke volume by a factor proportional to the ratio between the difference between Pdia and Pdic and the difference between Psys and Pdia.

6. A method as in claim 1, further including the following steps:

detecting a dicrotic time in the pressure signal;

evaluating a post-dicrotic first derivative of a post-dicrotic portion of the pressure signal at times after the dicrotic time;

detecting the time and corresponding pressure value of at least one local maximum pressure in the post-dicrotic portion of the pressure signal; and

estimating at least one of the selected impedance values as a predetermined function of the time and corresponding pressure value of the local maximum pressure.

7. A method as in claim 1, in which the step of calculating the CO estimate is performed based on the pressure signal during a single cardiac cycle.

8. A method as in claim 1, in which the pressure signal is uncalibrated, whereby the steps of calculating the estimate of the stroke volume and calculating the estimate of CO are independent of external calibration.

9. A method as in claim 1, in which the arterial blood pressure is sensed non-invasively using an externally mounted sensor.

10. A method as in claim 9, in which the arterial blood pressure is sensed using a finger-mounted pressure sensor.

11. A method as in claim 1, in which the step of sensing arterial blood pressure comprises inserting a catheter-mounted pressure sensor into an artery of the patient.

12. A method as in claim 11, in which the artery is the radial artery of the patient.

13. A method as in claim 11, in which the artery is the pulmonary artery of the patient.

14. A method as in claim 11, in which the artery is the femoral artery of the patient.

15. A method as in claim 11, in which the artery is the aortic artery of the patient.

16. A method as in claim 11, in which the artery is the aortic artery of the patient.

17. A method as in claim 1, further comprising the step of generating at least one calibrated impedance value using a thermodilution method before calculating the estimate of stroke volume.

18. A method for measuring cardiac output (CO) of a patient comprising the following steps:

sensing arterial blood pressure and converting the sensed arterial blood pressure to a pressure signal;

calculating area under the entire pressure signal including both pulsatile and non-pulsatile portions of the pressure signal, over a cardiac cycle;

estimating selected impedance values from the pressure signal calculating a mean pressure value of the pressure signal;

calculating a mean pressure value of the pressure signal;

calculating an estimate of stroke volume as function only of selected characteristics of the sensed pressure signal and of predetermined constants, including, the selected characteristics including the ratio between the calculated area and the estimated selected impedance values; and

calculating an estimate of CO as a function of the corrected, estimated stroke volume and a current heart rate value;

in which the pressure signal is uncalibrated, whereby the steps of calculating the estimate of the stroke volume of calculating the estimate of CO are independent of external calibration.

19. A method as in claim 18, further including the following steps:

detecting times and corresponding pressure values of a systolic peak and of a dicrotic notch in the pressure signal;

evaluating a second derivative of the pressure signal between the systolic peak and the dicrotic notch;

detecting the time and corresponding pressure value of at least one intermediate point in the pressure signal between the systolic peak and the dicrotic notch at which the second derivative has an extreme value; and

estimating at least one of the selected impedance values as a predetermined function of the time and corresponding pressure value of the intermediate point.

20. A method as in claim 18, further including the following steps:

detecting a systolic peak pressure Psys, a diastolic pressure Pdia, and a dicrotic pressure Pdic; and

scaling the estimated stoke volume by a factor proportional to the ratio between the difference between Pdia and Pdic and the difference between Psys and Pdia.

21. A system for measuring cardiac output (CO) of a patient, which does not require calibration, comprising:

pressure sensing means for sensing arterial blood pressure;

signal processing means for converting the sensed arterial blood pressure to a pressure signal;

processing means for calculating an estimate of stroke volume as a function only of selected characteristics of the sensed pressure signal, including calculating an area (A) under the entire pressure signal including both pulsatile and non-pulsatile portions of the pressure signal, over a cardiac cycle, and for calculating an estimate of CO as a function of the estimated stroke volume and a current heart rate value.

22. A system as in claim 21, in which the pressure sensing means is non-invasive and externally mounted on the patient.

23. A system as in claim 21, in which the pressure sensing means is a finger-mounted pressure sensor.

24. A system as in claim 21, in which the pressure sensing means is an intra-arterial, catheter-mounted pressure sensor.

25. A computer-readable medium having computer-executable instructions for performing steps for measuring cardiac output (CO) of a patient comprising the following steps:

sensing arterial blood pressure and converting the sensed arterial blood pressure to a pressure signal;

calculating an estimate of stroke volume as a function only of selected characteristics of the sensed pressure signal, including calculating an area (A) under the entire pressure signal including both pulsatile and non-pulsatile portions of the pressure signal, over a cardiac cycle; and

calculating and outputting an estimate of CO as a function of the estimated stroke volume and a current heart rate value.

26. A method for measuring cardiac output (CO) of a patient, comprising the following steps:

sensing arterial blood pressure and converting the sensed arterial blood pressure to a pressure signal;

calculating an estimate of stroke volume as a function only of selected characteristics of the sensed pressure signal; and

calculating an estimate of CO as a function of the estimated stroke volume and a current heart rate value;

wherein the method does not require calibration.

27. A method for measuring cardiac output (CO) of a patient, comprising the following steps:

sensing arterial blood pressure and converting the sensed arterial blood pressure to a pressure signal;

calculating an estimate of stroke volume as a function only of selected characteristics of the sensed pressure signal, including a time value and a corresponding pressure value at a selected point of the pressure signal; and

calculating an estimate of CO as a function of the estimated stroke volume and a current heart rate value.

28. A method as in claim 27, further comprising the step of generating at least one calibrated impedance value using a thermodilution method before calculating the estimate of stroke volume.

29. A system for measuring cardiac output (CO) of a patient, comprising:

pressure sensing means for sensing arterial blood pressure;

signal processing means for converting the sensed arterial blood pressure to pressure to a pressure signal;

processing means for calculating an estimate of stroke volume as a function only of selected characteristics of the sensed pressure signal, and for calculating an estimate of CO as a function of the estimated stroke volume and a current heart rate value;

wherein the system is constructed and arranged to perform the calculation of estimated CO without calibration.

30. A system for measuring cardiac output (CO) of a patient, comprising:

pressure sensing means for sensing arterial blood pressure;

signal processing means for converting the sensed arterial blood pressure to a pressure signal;

processing means for calculating an estimate of stroke volume as a function only of selected characteristics of the sensed pressure signal, including a time value and a corresponding pressure value at a selected point of the pressure signal, and for calculating an estimate of CO as a function of the estimated stroke volume and a current heart rate value.

31. A computer-readable medium having computer-executable instructions for performing steps for measuring cardiac output (CO) of a patient comprising the following steps:

sensing arterial blood pressure and converting the sensed arterial blood pressure to a pressure signal;

calculating an estimate of stroke volume as a function only of selected characteristics of the sensed pressure signal; and

calculating and outputting an estimate of CO as a function of the estimated stroke volume and a current heart rate value without using a calibration value.

32. A computer-readable medium having computer-executable instructions for performing steps for measuring cardiac output (CO) of a patient comprising the following steps:

sensing arterial blood pressure and converting the sensed arterial blood pressure to a pressure signal;

calculating an estimate of stroke volume as a function only of selected characteristics of the sensed pressure signal, including a time value and a corresponding pressure value at a selected point of the pressure signal; and

calculating and outputting an estimate of CO as a function of the estimated stroke volume and a current heart rate value.