Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids

• US 6,759,010 B2
• Filed: 07/20/2001
• Issued: 07/06/2004
• Est. Priority Date: 11/16/1998
• Status: Expired due to Term

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Severin, Erik J., Freund, Michael, Matzger, Adam J., Lewis, Nathan S.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Handy, Dwayne K.
• Application Number:
  US09/910,243
• Publication Number:
  US 20020141901A1
• Time in Patent Office: 1,082 Days
• Field of Search: 422/68.1, 422/82.01, 422/82.02, 422/83, 422/98, 204/400, 204/412, 204/406, 204/411, 204/431, 436/149, 436/150, 73/232, 73/233
• US Class Current: 422/82.02
• CPC Class Codes: G01N 15/0826 and measuring fluid flow rate, i.e. permeation rate or pressure change
• CPC Class Codes: G01N 2291/0217 Smoke, combustion gases
• CPC Class Codes: G01N 2291/0256 Adsorption, desorption, surface mass change, e.g. on biosensors
• CPC Class Codes: G01N 2291/02863 Electric or magnetic parameters
• CPC Class Codes: G01N 2291/0423 Surface waves, e.g. Rayleigh waves, Love waves
• CPC Class Codes: G01N 2291/0426 Bulk waves, e.g. quartz crystal microbalance, torsional waves
• CPC Class Codes: G01N 27/126 comprising organic polymers
• CPC Class Codes: G01N 29/022 Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices microdevices per se B81B
• CPC Class Codes: G01N 29/449 Statistical methods not provided for in G01N29/4409, e.g. averaging, smoothing and interpolation
• CPC Class Codes: G01N 33/0031 comprising two or more sensors, e.g. a sensor array electrochemical electrode arrays G01N27/27

Abstract

Chemical sensors for detecting the activity of a molecule or analyte of interest is provided. The chemical sensors comprise and array or plurality of sensors that are capable of interacting with a molecule of interest, wherein the interaction provides a response fingerprint. The fingerprint can be associated with a library of similar molecules of interest to determine the molecule'"'"'s activity and diffusion coefficient.

Claims

1. A sensor array comprising:

a plurality of sensors, each sensor comprising regions of a first conductive material and regions of a second material compositionally different than the first material, wherein the sensor provides an electrical path through the regions of the first material and the regions of the second material, and

wherein an at least two sensors of the plurality of sensors comprise a same first material and a same second material wherein the at least two sensors of the plurality of sensors comprise different thickness;

each of the sensors constructed to provide a first response when contacted with a first chemical analyte, and a second different response when contacted with a second different chemical analyte.

2. The sensor array of claim 1, further comprising a measuring apparatus in electrical communication with the plurality of sensors.

3. The sensor array of claim 1, wherein each of the sensors in the array have a different thickness than any other sensor in the array.

4. The sensor array of claim 1, wherein the first conductive material comprises an inorganic conductor or carbon black.

5. The sensor array of claim 1, wherein the response is a change in resistance in the sensors.

6. The sensor array of claim 1, wherein the second material compositionally different than the first material of the plurality of sensors are compositionally the same.

7. The sensor array of claim 1, wherein the second material compositionally different from the first material is selected from the group consisting of a polyaniline, an emeraldine salt of polyaniline, a polypyrrole, a polythiophene, and a polyEDOT, and the first conductive material is selected from the group consisting of Ag, Au, Cu, Pt, carbon black, and AuCu.

8. The sensor array of claim 1, further comprising a temperature control apparatus, the temperature control apparatus in thermal communication with at least one sensor.

9. The sensor array of claim 8, wherein the resistance of the sensor is Rm at temperature Tm when contacted with a chemical analyte, where m is an integer greater than 1.

10. The sensor array of claim 1, wherein the response is a change in impedance.

11. The sensor array of claim 4, wherein the inorganic conductor is selected from the group consisting of Ag, Au, Cu, Pt, and AuCu.

12. The sensor array of claim 4, wherein the first conductive material is carbon black.

13. The sensor array of claim 1, wherein the first conductive material is selected from the group consisting of an organic conductor, an inorganic conductor, and a mixed inorganic-organic conductor.

15. The sensor array of claim 1, wherein each of the sensors of the plurality of sensors comprise the same first material and second material.

16. The sensor array of claim 1, wherein the second material compositionally different than the first material is selected from the group consisting of a conductive organic material, a semi-conductive material, and a non-conductive material.

14. A sensor array system comprising:

a plurality of sensors;

a measuring apparatus, wherein the sensors are in communication with the measuring apparatus; and

a processor,

each sensor comprising regions of a first conductive material and regions of a second material compositionally different than the first material, wherein the sensor provides an electrical path through the regions of the first material and the regions of the second material, and wherein an at least two sensors of the plurality of sensors comprise a same first material and a same second material wherein the at least two sensors of the plurality of sensors comprise different thickness;

the sensors constructed to provide a first response when contacted with a first chemical analyte, and a second different response when contacted with a second different chemical analyte;

wherein the processor processes the difference between the first response and the second response and the change in response over a period of time.

17. The system of claim 14, wherein the measuring apparatus is an electrical measuring device in electrical communication with at least one sensor of the plurality of sensors.

18. The system of claim 14, wherein each of the sensors in the array have a different thickness than any other sensor in the array.

19. The system of claim 14, wherein the first conductive material comprises an inorganic conductor or a carbon black.

20. The system of claim 14, wherein the response is a change in resistance and/or a change in impedance in the sensors.

21. The system of claim 14, wherein the second material compositionally different than the first material is selected from the group consisting of a polyaniline, an emeraldine salt of polyaniline, a polypyrrole, a polythiophene, and a polyEDOT, and the first conductive material is selected from the group consisting of Ag, Au, Cu, Pt, carbon black, and AuCu.

22. The system of claim 14, further comprising a temperature control apparatus, the temperature control apparatus in thermal communication with at least one sensor of the plurality of sensors.

23. The system of claim 22, wherein the resistance of the sensor is Rm at temperature Tm when contacted with a chemical analyte, where m is an integer greater than 1.

24. The system of claim 18, wherein the inorganic conductor is selected from the group consisting of Ag, Au, Cu, Pt, and AuCu.

25. The system of claim 19, wherein the first conductive material is carbon black.

26. The system of claim 14, wherein the first conductive material is selected from the group consisting of an organic conductor, an inorganic conductor, and a mixed inorganic-organic conductor.

27. The system of claim 14, wherein each of the sensors of the plurality of sensors comprise the same first material and second material.

28. A sensor array made by a process comprising:

coating a substrate comprising at least two conductive leads in a first area to form an at least one first sensor comprising a film between the at least two conductive leads, wherein the film comprises a first conductive material and a second material compositionally different than the first conductive material; and

coating the substrate in a second area to form an at least one second sensor comprising a film between the at least two conductive leads, wherein the film comprises the first conductive material and the second material compositionally different than the first conductive material,

wherein the at least one first sensor and at least one second sensor have different thickness and wherein each sensor provides an electrical path through the film of each sensor such that the sensors provide a first response when contacted with a first chemical analyte, and a second different response when contacted with a second different chemical analyte.

29. The sensor array of claim 28, wherein the coating is by spraying, air-brushing, mechanical mixing, suspension casting, or solution casting a suspension or solution comprising the first conductive material and the second material compositionally different than the first conductive material.

30. The sensor array of claim 28, wherein the second material is selected from the group consisting of a conductive organic material, a semi-conductive material, and a non-conductive material.

31. A sensor array made by a process comprising:

coating a plurality of substrates each comprising at least two conductive leads with a suspension comprising a first conductive material and a second material compositionally different than the first material to form a plurality of sensors each comprising a film having regions of the first conductive material and regions of the second material compositionally different than the first material between the conductive leads on each substrate,

wherein at least one sensor of the plurality of sensors has a different film thickness than at least one other sensor of the plurality of sensors,

wherein each sensor of the plurality of sensors provides an electrical path through the regions of the first material and the regions of the second material such that the plurality of sensors provide a first response when contacted with a first chemical analyte and a second different response when contacted with a second different chemical analyte.

32. A sensor array comprising:

a plurality of differentially responsive sensors each sensor having a film composition comprising an at least one first material wherein a subset of the plurality of differentially responsive sensors comprises the same film composition and wherein the subset of the plurality of differentially responsive sensor comprises a different thickness of the film composition than at least one other member of the subset of differentially responsive sensors;

each of the sensors constructed to provide a first response when contacted with a first chemical analyte, and a second different response when contacted with a second different chemical analyte.

33. The sensor array of claim 32, wherein all of the sensors in the plurality of differentially responsive sensors comprises the same film composition.

34. The sensor array of claim 32, wherein the differentially responsive sensors are selected from the group consisting of a composite comprising regions of conductors and regions of insulators;

a bulk semiconducting organic polymer;

a metal oxide gas sensor;

a conducting polymer sensor;

a dye-impregnated polymer film on a fiber optic detector;

a polymer-coated micromirror;

an electrochemical gas detector;

a chemically sensitive field-effect transistor;

a carbon black-polymer composite;

a micro-electro-mechanical system device; and

a micro-opto-electro-mechanical system device.

35. The sensor array of claim 32, wherein the differentially responsive sensor is a chemiresistor sensor.

36. The sensor array of claim 35, wherein the film comprises a first material and a second material compositionally different than the first material.

37. The sensor array of claim 36, wherein the first material is selected from the group consisting of Ag, Au, Cu, Pt, carbon black, and AuCu, and the second material compositionally different than the first material is selected from the group consisting of a non-conductive material, a semi-conductive material, a conductive organic material, wherein the conductive organic material is selected from the group consisting of a polyaniline, an emeraldine salt of polyaniline, a polypyrrole, a polythiophene, and a polyEDOT.