High affinity RNA ligands of basic fibroblast growth factor
First Claim
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1. A method for inhibiting angiogenesis comprising administering a pharmaceutically effective amount of a nucleic acid ligand to bFGF, wherein said ligand has an increased affinity to bFGF relative to a total candidate nucleic acid mixture.
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Abstract
Methods are described for the identification and preparation of nucleic acid ligand solutions to basic fibroblast growth factor (bFGF). Included in the invention are nucleic acid ligands to bFGF which are inhibitors of bFGF and 2′-amino-modified RNA ligands to bFGF.
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8 Claims
- 1. A method for inhibiting angiogenesis comprising administering a pharmaceutically effective amount of a nucleic acid ligand to bFGF, wherein said ligand has an increased affinity to bFGF relative to a total candidate nucleic acid mixture.
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