Substantially monostatic, substantially confocal optical systems for examination of samples

• US 6,760,613 B2
• Filed: 06/24/2002
• Issued: 07/06/2004
• Est. Priority Date: 12/23/1998
• Status: Expired due to Fees

• Current Assignee: Luma Imaging Corp. (SpectraScience, Inc.)
• Original Assignee: MediSpectra, Inc. (SpectraScience, Inc.)
• Inventors: Modell, Mark, Nordstrom, Robert, Zelenchuk, Alexander
• Primary Examiner(s): MANTIS MERCADER, ELENI M
• Application Number:
  US10/178,772
• Publication Number:
  US 20020183626A1
• Time in Patent Office: 743 Days
• Field of Search: 600/476, 600/407, 600/473, 600/478, 600/474, 600/475, 600/425
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0068 Confocal scanning

Abstract

The present invention relates to systems and methods for examining a sample using a substantially monostatic, substantially confocal optical system comprising transmitting optics that focus an illuminating light upon the sample and receiving optics that collect light emitted from the sample following illumination thereof. In certain embodiments, the receiving optics may be arranged circumferentially around the light path traversed by the illuminating light. In certain embodiments, video apparatus may be included to produce images or to align the system in proximity to the target tissue. The systems and methods of the present invention may be directed towards the examination of a body tissue to provide a medical diagnosis.

Claims

1. A system for examining a sample, comprising:

an optical probe capable of illuminating a sample;

a substantially monostatic, substantially confocal optical system comprising

transmitting optics that direct illumination upon the sample, and

receiving optics, comprising components separate and distinct from the transmitting optics, that collect light emitted from the sample following illumination thereof; and

a barrier element adapted to inhibit scattered illumination from entering the receiving optics.

2. The system of claim 1, further comprising reflective optical components.

3. The system of claim 1, further comprising refractive optical components.

4. The system of claim 1, wherein the optical system directs illumination at a location in the sample and wherein the optical system collects light emitted as a result of illumination from said location.

5. The system of claim 1, wherein the receiving optics are arranged circumferentially around a light path for the illumination.

6. The system of claim 1, further comprising a scanner that directs the illumination to illuminate the sample in a preselected pattern.

7. The system of claim 6, wherein the preselected pattern comprises a rectilinear pattern.

8. The system of claim 6, wherein the preselected pattern comprises a hexagonal pattern.

9. The system of claim 1, wherein the illumination comprises laser light and wherein the light emitted from the sample comprises fluorescence.

10. The system of claim 1, the illumination is provided by a broadband source and the emitted light comprises elastic backscattered light.

11. The system of claim 1, wherein the illumination is provided by a pulsed laser and the emitted light comprises Raman scattered light.

12. The system of claim 1, wherein the illumination comprises light from a nitrogen laser.

13. The system of claim 1, wherein the illumination comprises light from a Nd:

YAG laser, tripled in output frequency to a wavelength of 355 nm.

14. The system of claim 1, wherein the illumination comprises broadband light provided by a xenon lamp.

15. The system of claim 1, further comprising a measuring system that produces quantitative data related to the light emitted from the sample.

16. The system of claim 15, further comprising a processor that processes the quantitative data to determine the characteristic of the sample.

17. The system of claim 15, further comprising a video system, wherein the video system transmits to a display an image of a surface of the sample.

18. The system of claim 15, further comprising a position sensor whereby a position of the optical probe in relation to the sample may be determined.

19. The system of claim 18, wherein the position sensor comprises a focusing image projected upon the surface of the sample, whereby the position of the optical probe in relation to the sample is determined by evaluating clarity of focus for the focusing image.