Implantable multi-chamber cardiac stimulation device with sensing vectors

• US 6,760,622 B2
• Filed: 07/03/2001
• Issued: 07/06/2004
• Est. Priority Date: 07/03/2001
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Falkenberg, Eric, Helland, John R.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US09/897,300
• Publication Number:
  US 20030009197A1
• Time in Patent Office: 1,099 Days
• Field of Search: 600/512, 607/9, 607/5
• US Class Current: 607/9
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

An implantable multi-chamber cardiac stimulation device and method are provided for accurately sensing cardiac activity from three or four heart chambers using passive sensing electrodes placed in each heart chamber. Multiple intra-chamber or inter-chamber sensing vectors are established between passive sensing electrodes. Sampled sensing vector signals are processed such that a cardiac depolarization may be accurately detected, as well as its origin and direction of propagation. Time intervals between detected depolarization signals may be used to determine conduction time or heart rate. Diagnostic indicators of heart failure condition normally obtained from a 12-lead surface ECG study, such as P-wave or R-wave duration, may also be determined from the sensing vectors. Based on precise and detailed evaluation of sensing vector signals, stimulation therapy may be provided immediately upon a detected change in heart rhythm or heart failure condition.

Claims

1. A method of accurately detecting cardiac events, for use in a multi-chamber cardiac stimulation device, comprising the steps of:

sensing cardiac signals from passive sensing electrodes placed in at least three cardiac chambers;

establishing a plurality of sensing vectors from the cardiac signals;

detecting a cardiac depolarization from the sensing vectors by comparing a sensing vector to a detection threshold; and

selectively delivering a stimulation energy based on a detected cardiac depolarization indicative of a change in a heart function parameter.

2. The method of claim 1, wherein the step of selectively delivering the stimulation energy includes delivering stimulation energy upon any one of a detected change a heart rhythm or a heart failure condition.

3. The method of claim 1, wherein the step of establishing the sensing vectors includes establishing intra-chamber sensing vectors.

4. The method of claim 3, wherein the step of establishing the sensing vectors further includes establishing inter-chamber sensing vectors.

5. The method of claim 4, wherein the step of detecting the cardiac depolarization includes sampling the vector signals to identify an origin and a direction of propagation of the cardiac depolarization.

6. The method of claim 5, wherein the step of detecting the cardiac depolarization includes comparing a vector signal to a predetermined signal morphology template.

7. The method of claim 5, further including the step of classifying the detected depolarization.

8. The method of claim 5, wherein the classifying step includes classifying the detected depolarization according to the identified origin.

9. The method of claim 5, wherein the classifying step includes classifying the detected depolarization according to the identified direction of conduction.

10. The method of claim 4, wherein the step of establishing the sensing vectors includes establishing a vector between a right atrium and a left atrium.

11. The method of claim 4, wherein the step of establishing the sensing vectors includes establishing a vector between a right atrium and a right ventricle.

12. The method of claim 4, wherein the step of establishing the sensing vectors includes establishing a vector between a right atrium and a left ventricle.

13. The method of claim 4, wherein the step of establishing the sensing vectors includes establishing a vector between a left atrium and a right ventricle.

14. The method of claim 4, wherein the step of establishing the sensing vectors includes establishing a vector between a left atrium and a left ventricle.

15. The method of claim 4, wherein the step of establishing the sensing vectors includes establishing a vector between a right ventricle and a left ventricle.

16. The method of claim 4, wherein the step of establishing the sensing vectors includes adding two or more cardiac signals.

17. The method of claim 4, wherein the step of establishing the sensing vectors includes subtracting two or more cardiac signals.

18. The method of claim 1, wherein the step of establishing the sensing vectors further includes establishing inter-chamber sensing vectors.

19. The method of claim 1, further including the step of detecting a heart rate by determining a time interval between a first detected depolarization and a second detected depolarization.

20. The method of claim 19, wherein the step of selectively delivering the stimulation energy includes delivering stimulation energy in response to a heart rate determined to be pathologic.

21. The method of claim 20, wherein the step of selectively delivering the stimulation energy includes delivering a stimulation pulse to a heart chamber at a predetermined time interval following a detected cardiac depolarization.

22. The method of claim 20, wherein the step of selectively delivering the stimulation energy includes withholding stimulation.

23. The method of claim 1, further including the step of measuring a conduction time as a time interval between a first detected depolarization and a second detected depolarization.

24. The method of claim 23, wherein the step of selectively delivering the stimulation energy includes delivering stimulation energy in response to a change in the conduction time.

25. The method of claim 1, further including the step of determining a diagnostic parameter as an indication of heart function.

26. The method of claim 25, wherein the step of determining the diagnostic parameter includes determining a duration of a depolarization signal.

27. A multi-chamber cardiac stimulation device that accurately detects cardiac events, comprising:

passive sensing electrodes placed in at least three cardiac chambers;

sensing circuits, connected to the sensing electrodes, that sense cardiac signals;

control circuit that establishes a plurality of sensing vectors from the cardiac signals, and that detects a cardiac depolarization from the sensing vectors by comparing a sensing vector to a detection threshold; and

a pulse generator that selectively delivers a stimulation energy based on a detected cardiac depolarization indicative of a change in a heart function parameter.

28. The device of claim 27, wherein the pulse generator delivers stimulation energy upon any one of a detected change a heart rhythm or a heart failure condition.

29. The device of claim 27, wherein the sensing vectors include intra-chamber sensing vectors.

30. The device of claim 29, wherein the sensing vectors further include inter-chamber sensing vectors.

31. The device of claim 27, wherein the detected cardiac depolarization includes an origin and a direction of propagation.

32. The device of claim 27, wherein the sensing vectors include any one or more of the following:

a vector between a right atrium and a left atrium;

a vector between a right atrium and a right ventricle;

a vector between a right atrium and a left ventricle;

a vector between a left atrium and a right ventricle;

a vector between a left atrium and a left ventricle; and

a vector between a right ventricle and a left ventricle.

33. The device of claim 27, wherein the pulse generator delivers the stimulation energy to a heart chamber at a predetermined time interval following the detected cardiac depolarization.

34. A multi-chamber cardiac stimulation device that accurately detects cardiac events, comprising:

means for passively sensing cardiac signals;

means for establishing a plurality of sensing vectors from the cardiac signals;

means for detecting a cardiac depolarization from the sensing vectors by comparing a sensing vector to a detection threshold; and

means for selectively delivering a stimulation energy based on a detected cardiac depolarization indicative of a change in a heart function parameter.

35. The device of claim 34, wherein the heart function parameter includes any one of a detected change a heart rhythm or a heart failure condition.

36. The device of claim 34, wherein the sensing vectors include intra-chamber sensing vectors.

37. The device of claim 36, wherein the sensing vectors further include inter-chamber sensing vectors.

38. The device of claim 34, wherein the detected cardiac depolarization includes an origin and a direction of propagation.

39. The device of claim 34, wherein the sensing vectors include any one or more of the following:

a vector between a right atrium and a left atrium;

a vector between a right atrium and a right ventricle;

a vector between a right atrium and a left ventricle;

a vector between a left atrium and a right ventricle;

a vector between a left atrium and a left ventricle; and

a vector between a right ventricle and a left ventricle.

40. The device of claim 34, wherein the pulse generator delivers the stimulation energy in response to a change in the conduction time at a predetermined time interval following the detected cardiac depolarization.