Passive immunization treatment of Alzheimer's disease
First Claim
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1. A method of prophylactically or therapeutically treating Alzheimer'"'"'s disease, comprising administering to the patient an effective dosage of a pharmaceutical composition comprising a humanized or chimeric antibody that specifically binds to an epitope within Aβ
- 1-7, and hereby prophylactically or therapeutically treating the patient.
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Abstract
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer'"'"'s disease. Preferred agents including N-terminal fragments of Aβ and antibodies binding to the same.
295 Citations
36 Claims
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1. A method of prophylactically or therapeutically treating Alzheimer'"'"'s disease, comprising administering to the patient an effective dosage of a pharmaceutical composition comprising a humanized or chimeric antibody that specifically binds to an epitope within Aβ
- 1-7, and hereby prophylactically or therapeutically treating the patient.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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