Devices and methods for occlusion of the uterine arteries

• US 6,764,488 B1
• Filed: 04/17/2000
• Issued: 07/20/2004
• Est. Priority Date: 12/08/1998
• Status: Expired due to Fees

• Current Assignee: Vascular Control Systems, Inc. (Johnson & Johnson)
• Original Assignee: Vascular Control Systems, Inc. (Johnson & Johnson)
• Inventors: Jones, Michael, Lubock, Paul, Burbank, Fred
• Primary Examiner(s): Gibson, Roy D.
• Application Number:
  US09/550,908
• Time in Patent Office: 1,555 Days
• Field of Search: 606/32, 606/34, 606/38, 606/41-52, 606/157, 606/158, 606/205, 606/208, 606/211, 607/101, 607/102, 128/831, 601/2
• US Class Current: 606/51
• CPC Class Codes: A61B 17/12013 for use in minimally invasive surgery, e.g. endoscopic surgery
• CPC Class Codes: A61B 17/42 Gynaecological or obstetrical instruments or methods ligaturing clamps or clips for the umbilical cord A61B17/122; curettage A61B17/320708; dilators A61M29/00
• CPC Class Codes: A61B 18/1485 having a short rigid shaft for accessing the inner body through natural openings
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00

Abstract

Devices and methods are disclosed for treating a uterine disorder which receive its blood supply from a uterine artery. In particular, uterine fibroids are effectively treated by occluding the uterine arteries using trans-vaginal, trans-uterine, transrectal, or retroperitoneal approaches. The devices and methods are advantageous because the inventive procedures may be performed by a patient'"'"'s gynecologist in the course of treatment, avoiding the need for referrals to specialist practitioners and for more radical treatments, such as hysterectomies. The methods include both temporary and permanent occlusion of the arteries. A cannula carries an imaging device and a member which will easily penetrate tissue, the member including a device which partially or completely, and temporarily or permanently, occludes a uterine artery.

Claims

1. An intravaginal system for treating a patient'"'"'s uterine disorder by at least partially occluding a uterine artery, comprising:

a Doppler ultrasound sensor which is configured for locating a uterine artery by sensing blood flow through the uterine artery;

an elongated member which is configured for accessing an anatomical region adjacent to the located uterine artery and which has a distal portion; and

an occluding member which is disposed on the distal portion of the elongated member, and which is configured to apply pressure to the located uterine artery to at least partially occlude the artery and to thereby decrease blood flow through the artery.

2. A system in accordance with claim 1, wherein the elongated member is movable in a first direction, and wherein the elongated member includes a stabilizing member configured to press against a wall of a uterus in a second direction, substantially opposite the first direction.

3. A system in accordance with claim 2, wherein the stabilizing member is formed at least in part of an inflatable element.

4. A system in accordance with claim 2, wherein the stabilizing member includes a belt which has a distal end fixedly attached to the system and which is formed of a material and is configured to bow away from the elongated member and press against the uterine wall.

5. A system in accordance with claim 1, wherein the elongated member includes a burrowing element on the distal portion.

6. A system in accordance with claim 1, wherein the elongated member includes a tubular cannula, which has a distal end and a probe mounted the distal end.

7. A system in accordance with claim 1, including a cannula which has a proximal end and a distal end, the cannula which has a pullwire system capable of deflecting the cannula distal end, including a wire attached to the cannula at a point adjacent the cannula distal end and extending proximally along the cannula, which has a first locking member attached to the wire proximal of the point, and which has a second locking member attached to the cannula which is configured to engage with the first locking member to fix a position of the wire.

8. A system in accordance with claim 1, including a guide configured to direct the placement of the elongated member near to the patient'"'"'s uterine artery.

9. An intravaginal system for treating a patient'"'"'s uterine disorder by at least partially occluding a uterine artery, comprising:

an elongated member for accessing an anatomical region adjacent to the uterine artery to be occluded having a proximal portion and a distal portion

a Doppler ultrasonic transducer which is configured for locating the uterine artery to be occluded by sensing blood flow through the uterine artery when energized; and

an occluding member which is disposed on the distal portion of the elongated member, which is configured to be movable from a retracted position to an extended position to occlude the uterine artery.

10. A system in accordance with claim 9, wherein the occluding member is a clamping element configured to apply pressure to the patient'"'"'s uterine artery.

11. A system in accordance with claim 10, wherein the clamping element has a clip formed of resilient material.

12. A system in accordance with claim 10, wherein the clamping element is movable between an open orientation and a closed orientation.

13. A system in accordance with claim 10, wherein the clamping element has a pair of jaws pivotally connected at a pivot point, and holds a clip formed of a deformable material.

14. A system in accordance with claim 10, wherein the elongated member has a distal end, a port in the distal end and a lumen extending to the port in the distal end, and wherein a guidewire having an atraumatic distal tip is slidably disposed within the lumen.

15. A system in accordance with claim 10, wherein the elongated member has a guide port proximal of the distal end and a guide lumen extending proximally from the guide port, and wherein the occluding member is positioned in the guide lumen and is slidably disposed in the guide lumen.

16. A system in accordance with claim 15, wherein the elongated member has a guide member at a distal end of the guide lumen adjacent the guide port, the guide member directing the occluding member into the sensing plane when moved from the retracted position to the extended position.

17. A system in accordance with claim 10, wherein the elongated member is formed of a substantially rigid material, and has a bent portion proximal of the elongated member distal end.

18. A system in accordance with claim 10, wherein the elongated member includes a resilient flexible portion proximal of the elongated member distal end.

19. A system in accordance with claim 18, wherein the flexible portion includes a stabilizing member, portions of which are distal to the flexible portion proximal end, and having uterine wall engaging portions which are positioned on the elongated member opposite the sensing plane.

20. A system in accordance with claim 19, wherein the stabilizing member is movable from a retracted position, and an extended position in which the uterine wall engaging portions are configured to extend from the elongated member, so the stabilizing member bears against a uterine wall and bends the elongated member at the resilient flexible portion toward the sensing plane.

21. A system in accordance with claim 19, wherein the stabilizing member includes a resilient belt which has a distal end fixedly attached to the elongated member at a point adjacent the elongated member distal end, which extends proximally from the resilient belt distal end, and which is longitudinally relatively rigid and laterally less rigid.

22. A system in accordance with claim 19, wherein the stabilizing member has an inflatable element and an inflation lumen which is in fluid communication with the inflatable element, and which extends proximally from the inflatable element.

23. A system for treating a patient'"'"'s uterine disorder by at least partially occluding at least one of the patient'"'"'s uterine arteries, comprising:

an elongated member for accessing an anatomical region adjacent one of the uterine arteries which has a proximal end and a distal end and which has a Doppler ultrasound sensor capable of sensing the location of the uterine artery by sensing blood flow therethrough; and

an occluding member which has a distal end and which is movable independent from and relative to the elongated member between a retracted position and an extended position to occlude the uterine artery.