Apparatus and method for treating atherosclerotic vascular disease through light sterilization

• US 6,764,501 B2
• Filed: 04/09/2002
• Issued: 07/20/2004
• Est. Priority Date: 04/10/2001
• Status: Expired due to Fees

• Current Assignee: Robert A. Ganz
• Original Assignee: Robert A. Ganz
• Inventors: Ganz, Robert A.
• Primary Examiner(s): PEFFLEY, MICHAEL F
• Application Number:
  US10/119,855
• Publication Number:
  US 20020147443A1
• Time in Patent Office: 833 Days
• Field of Search: 607/88-94, 600/9-12, 600/2, 600/3, 600/7
• US Class Current: 607/92
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2018/1807 using light other than laser radiation
• CPC Class Codes: A61B 2018/2211 Plurality of fibres
• CPC Class Codes: A61N 2005/0651 Diodes
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body

Abstract

Atherosclerotic vascular disease is treated by exposing the interior of an artery or vein to visible or ultraviolet light of a selected spectrum to thereby sterilize the artery, eradicating infectious pathogens and reverse the pathogenesis of atherosclerotic artery disease. A fiber optic bundle positioned via an intra-arterial catheter is connected to an appropriate light radiation source located outside of the body during treatment. In another form, the light energy is produced by means of a light energy source located at the distal tip of the instrument shaft positioned centrally within the atherosclerotic plaque formation. In this case, the power source at the distal tip of the instrument can be a light emitting diode (LED) or a transparent tube containing a chemilumlumenescent substance for producing cool light energy within the vessel to destroy the pathogenic microorganisms in the surrounding plaque or vessel without damage to the body tissue of the patient.

Claims

1. An apparatus for the use of treating atherosclerotic vascular disease within the body of a patient, said apparatus comprising,

an instrument body having an elongated shaft that is sized and constructed for insertion into the interior of an atherosclerotic blood vessel of a patient,

a light radiation source connected to the shaft for destroying or debilitating microorganisms within the vessel,

said light radiation source is adapted to expose a interior wall of the vessel to light radiation with a wavelength of a selected rang to kill or debilitate pathogenic microorganisms supported on or within the plaque or endothelium lining the vessel that is being treated without damage, destruction or ablation of the vessel or the surrounding body tissue and

the light radiation source consists of cool light producing little or no heat that can be sensed and consisting of wavelengths between about 300 nm and 470 nm such that the microorganisms are killed or debilitated without destruction of the blood vessels of the patient.

2. The apparatus of claim 1 wherein the shaft comprises a fiber optic bundle and the apparatus includes means for focusing a beam of light from the radiation source onto a proximal end of the fiber optic bundle.

3. The apparatus of claim 2 wherein a lens is provided proximate the light source to focus a collimated beam of light from the light source onto the proximal end of the fiber optic bundle passing through the shaft.

4. The apparatus of claim 1 wherein the light radiation source comprises an incandescent lamp for providing visible light energy.

5. The apparatus of claim 1 wherein the light source is a light emitting diode.

6. The apparatus of claim 5 wherein the shaft is an elongated flexible element having electrical conductors extending therealong and the light emitting diode is connected to the conductors at a distal end of th element and is adapted to be positioned by means of the shaft during use within vessel of the patient at the site of the atherosclerotic vascular disease.

7. The apparatus of claim 1 wherein the shaft is a fiber optic bundle that has a light distributing distal end and a balloon surrounds the distal end for occluding the vessel thereby enclosing the distal end such that light therefrom passes through said balloon.

8. The apparatus of claim 1 wherein the light source is a transparent container enclosing a chemiluminescent agent so as to isolate the chemiluminescent agent from the body of the patient.

9. The apparatus of claim 8 wherein the light source is a transparent plastic capsule containing a chemiluminescent agent.

10. The apparatus of claim 8 wherein the light source is a transparent tube containing a chemiluminescent agent and electrodes are electrically coupled to the light source for passing an electric current therethrough.

11. The apparatus of claim 8 wherein the light source comprises two chemically reactive agents separated by a barrier at can be removed by manipulating the light source, thereby causing the agents to react chemically for producing light energy.

12. A method of treating atherosclerotic vascular disease comprising,

providing a flexible shaft that is constructed, sized and arranged to enter the vascular system including an artery or vein of a human patient or animal suffering from atherosclerotic vascular disease,

providing a source of cool visible light energy consisting of a selected wavelength between about 300 nm and 470 nm,

providing a said shaft with a light energy distribution head at a distal end thereof for distributing the light energy from the end of the shaft,

placing the shaft into the body of the patient,

positioning the distribution head within the portion of a blood vessel where the atherosclerotic disease is located,

distributing light energy from the distribution head so as to kill or debilitate pathogenic microorganisms that are present in the vessel or in plaque lining the vessel

said light energy reducing or eliminating or more of the symptoms of vascular inflammatory disease present in vessel or in plague lining the vessel without damage, destruction or ablation of a wall of the vessel or the surrounding body tissue.

13. The method of claim 12 including,

providing the distribution head with a container that is transparent to the light energy,

enclosing a chemiluminescent agent within the transparent container of the distribution head so as to isolate the chemilluminescent agent from the body of the patient and,

causing the chemiluminescent agent to luminescence for producing said light energy.

14. The method of claim 13 including the step of providing at east two chemically reactive materials for forming said chemiluminescent agent,

providing a removable barrier between said two chemical reactive materials and

removing said barrier to enable the reactive material to mix for causing the luminescence of said chemiluminescent agent.

15. The method of claim 14 wherein the barrier is removed by manipulating the distribution head.

16. The method of claim 12 including the step of,

providing a light emitting diode within the distribution head and,

applying an electric current to the diode for producing said light energy.

17. The method of claim 13 including the step of applying an electrical current across said chemiluminescent agent to facilitate the production of light energy thereby.