System for delaying drug delivery up to seven hours

• US 6,764,697 B1
• Filed: 02/13/1998
• Issued: 07/20/2004
• Est. Priority Date: 06/27/1991
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Wat, Pamela K., Jao, Frank, Huynh, Hoa T., Mc Chesney, Kathy, Wong, Patrick S. -L.
• Primary Examiner(s): Spear, James M.
• Application Number:
  US09/023,574
• Time in Patent Office: 2,349 Days
• Field of Search: 424/473, 424/465, 424/464, 424/472
• US Class Current: 424/473
• CPC Class Codes: A61K 31/275 Nitriles; Isonitriles
• CPC Class Codes: A61K 31/277 having a ring, e.g. verapamil
• CPC Class Codes: A61K 31/401 Proline; Derivatives thereof, e.g. captopril
• CPC Class Codes: A61K 31/4422 1,4-Dihydropyridines, e.g. nifedipine, nicardipine
• CPC Class Codes: A61K 31/554 having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
• CPC Class Codes: A61K 38/556 Angiotensin converting enzyme inhibitors
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A dosage form is disclosed comprising means for delaying the delivery of drug from the dosage form following the administration of the dosage form to a patient in need of drug therapy.

Claims

1. A method for providing a drug to a patient during the morning hours, comprising:

administering to the patient at bedtime a dosage form for the delayed-delivery of the drug, the dosage form comprising (1) a core including a drug useful in the treatment of hypertension or angina, and (2) a layer substantially surrounding the core, the layer comprising hydroxyethylcellulose having a molecular weight of 8500 to 4,000,000;

the layer delaying the release of the drug from the core until the morning hours dependent upon the weight of the layer to permit delivery of the drug at waking hours and to treat hypertension or angina in the patient.