Methods of screening and diagnosing esophageal cancer by determining guanylin cyclase C expression
First Claim
1. An in vitro method of screening an individual who is suspected of having primary and/or metastatic esophageal cancer for primary and/or metastatic esophageal cancer cells comprising the steps of examining a sample of extraintestinal tissue and/or body fluids from said individual to determine whether guanylin cyclase C is being expressed by cells in said sample wherein expression of guanylin cyclase C indicates the presence of primary and/or metastatic esophageal cancer cells in said sample.
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Abstract
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating and preventing primary and/or metastatic stomach or esophageal cancer are disclosed.
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Citations
30 Claims
- 1. An in vitro method of screening an individual who is suspected of having primary and/or metastatic esophageal cancer for primary and/or metastatic esophageal cancer cells comprising the steps of examining a sample of extraintestinal tissue and/or body fluids from said individual to determine whether guanylin cyclase C is being expressed by cells in said sample wherein expression of guanylin cyclase C indicates the presence of primary and/or metastatic esophageal cancer cells in said sample.
- 11. An in vitro method of screening an individual suspected of having primary and/or metastatic esophageal cancer for the presence of primary and/or metastatic esophageal cancer cells comprising the steps of examining a sample of extraintestinal tissue and/or body fluids from said individual to determine whether guanylin cyclase C gene transcription or translation product is present in said sample wherein presence of guanylin cyclase C gene transcription and translation products indicate the presence of primary and/or metastatic esophageal cancer cells in said sample.
- 21. An in vitro method of confirming that a tumor cell removed from a patient suspected of having esophageal cancer cells is a esophageal tumor cell comprising the step of determining whether said tumor cell expresses guanylin cyclase C wherein expression of guanylin cyclase C indicates that the tumor cell is a esophageal tumor cell.
- 25. A method of diagnosing an individual who has esophageal cancer comprising the steps of examining a sample of esophagus tissue to detect the presence of guanylin cyclase C transcript or translation product wherein the presence of guanylin cyclase C transcript or translation product in said sample indicates esophageal cancer.
Specification