Human ion channel protein and polynucleotides encoding the same

• US 6,767,736 B2
• Filed: 04/03/2001
• Issued: 07/27/2004
• Est. Priority Date: 04/03/2000
• Status: Expired due to Fees

• Current Assignee: Lexicon Genetics, Incorporated
• Original Assignee: Lexicon Genetics, Incorporated
• Inventors: Hu, Yi, Kieke, James Alvin, Sands, Arthur T., Zambrowicz, Brian, Friedrich, Glenn, Nehls, Michael C., Turner, C. Alexander Jr.
• Primary Examiner(s): PAK, MICHAEL D
• Application Number:
  US09/825,147
• Publication Number:
  US 20020042505A1
• Time in Patent Office: 1,211 Days
• Field of Search: 536/23.5
• US Class Current: 435/320.1
• CPC Class Codes: A61P 15/08 for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 9/06 Antiarrhythmics
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07K 14/705 Receptors; Cell surface antigens; Cell surface determinants tumour specific antigens C07K14/4748

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:

1.

2. An isolated nucleic acid molecule comprising a nucleotide sequence that:

(a) encodes the amino acid sequence shown in SEQ ID NO;

2; and

(b) hybridizes to the nucleotide sequence of SEQ ID NO;

1 or the complement thereof under highly stringent conditions of 0.5 M NaHPO, 7% sodium dodecyl sulfate (SDS) and 1 mM EDTA at 65°

C. and washing in 0.1×

SSC/0.1% SDS at 68°

C.

3. An isolated nucleic acid molecule comprising a nucleotide sequence that encodes the amino acid sequence shown in SEQ ID NO:

2.

4. A recombinant expression vector comprising the isolated nucleic acid molecule of claim 3.

5. The recombinant expression vector of claim 4, wherein the isolated nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

1.

6. A host cell comprising the recombinant expression vector of claim 4.