Multiple parallel processing assembly

• US 6,770,245 B2
• Filed: 04/29/2003
• Issued: 08/03/2004
• Est. Priority Date: 12/15/1999
• Status: Expired due to Fees

• Current Assignee: UOP Llc (Honeywell International Inc.)
• Original Assignee: UOP Llc (Honeywell International Inc.)
• Inventors: Karlsson, Arne, Dahl, Ivar M., Akporiaye, Duncan E., Wendelbo, Rune
• Primary Examiner(s): Johnson, Jerry D.
• Assistant Examiner(s): RIDLEY, BASIA ANNA
• Application Number:
  US10/426,086
• Publication Number:
  US 20030206830A1
• Time in Patent Office: 462 Days
• Field of Search: 422/82.12, 422/99, 422/101-104, 422/130, 422/239, 422/139-141, 422/145-146, 436/155, 436/159, 436/161, 436/173, 436/34, 436/37
• US Class Current: 506/40
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00283 Reactor vessels with top opening
• CPC Class Codes: B01J 2219/00286 Reactor vessels with top and bottom openings
• CPC Class Codes: B01J 2219/00299 Generally cylindrical reactor vessels
• CPC Class Codes: B01J 2219/00308 interchangeably mounted in racks or blocks
• CPC Class Codes: B01J 2219/00351 Means for dispensing and evacuation of reagents
• CPC Class Codes: B01J 2219/00423 using filtration, e.g. through porous frits
• CPC Class Codes: B01J 2219/00495 Means for heating or cooling the reaction vessels
• CPC Class Codes: B01J 2219/00585 Parallel processes
• CPC Class Codes: B01J 2219/00698 Measurement and control of process parameters
• CPC Class Codes: B01J 2219/00702 Processes involving means for analysing and characterising the products
• CPC Class Codes: B01J 2219/00745 Inorganic compounds
• CPC Class Codes: B01J 2219/00747 Catalysts
• CPC Class Codes: B01J 35/19 Catalysts containing parts with different compositions
• CPC Class Codes: C40B 30/08 by measuring catalytic activity
• CPC Class Codes: C40B 40/18 Libraries containing only inorganic compounds or inorganic materials
• CPC Class Codes: C40B 60/14 for creating libraries
• CPC Class Codes: G01N 31/10 using catalysis
• CPC Class Codes: Y10T 436/24 Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

A multiple parallel processing assembly has been developed. The assembly has (1) a plurality of vessels for containing material, each vessel having an open end and a fluid permeable end (2) a plurality of bottoms, each bottom having an open end and a closed end with the plurality being supported by a single first support plurality of vessels positioned within the plurality of bottoms; (3) a plurality of tops supported by a single second support with the plurality of tops engaged with the plurality of bottoms to form a plurality of sealed independent chambers; and (4) a plurality of fluid conduits in fluid communication with the chambers.

Claims

1. A multiple parallel processing assembly comprising:

a) a plurality of bottoms, each bottom having a closed end and an open end, said plurality of bottoms supported by a first support;

b) a plurality of tops supported by a second support, said plurality of tops engaged with said open ends of the plurality of bottoms to form a plurality of independent chambers;

c) a plurality of vessels, each vessel having a fluid permeable end and an open end, said each vessel contained within a corresponding independent chamber so that said fluid permeable end of said vessel is further from said open end of said bottom than is said open end of said vessel, and;

d) a plurality of fluid conduits in fluid communication with the plurality of independent chambers.

2. The multiple parallel processing assembly of claim 1 wherein a material is contained within the vessel.

3. The multiple parallel processing assembly of claim 2 wherein the material is a solid or a liquid.

4. The multiple parallel processing assembly of claim 1 further comprising at least one mixing device capable of mixing within the independent chambers.

5. The multiple parallel processing assembly of claim 1 wherein the plurality of bottoms and the first support are integrated to form an assembly which may be manipulated as a unit.

6. The multiple parallel processing assembly of claim 1 wherein the plurality of tops and the second support are a monolithic unit.

7. The multiple parallel processing assembly of claim 1 wherein the plurality of tops and the second support are integrated to form an assembly which may be manipulated as a unit.

8. The multiple parallel processing assembly of claim 1 wherein the plurality of tops and the second support are a monolithic unit.

9. The multiple parallel processing assembly of claim 1 wherein two or more of the plurality of fluid conduits are connected to each of the plurality of tops or each of the plurality of bottoms.

10. The multiple parallel processing assembly of claim 1 wherein one or more of the plurality of fluid conduits are connected to each of the plurality of bottoms and each of the plurality of tops.

11. The multiple parallel processing assembly of claim 1 wherein the bottoms and the first support are constructed of material stable at temperatures ranging from about −

196°

C. to about 1000°

C.

12. The multiple parallel processing assembly of claim 1 further comprising at least one seal engaging the plurality of bottoms and the plurality of corresponding tops to form sealed independent chambers.

13. The multiple parallel processing assembly of claim 12 wherein each seal engages a bottom and a corresponding top to form one of the independent chambers.

14. The multiple parallel processing assembly of claim 12 further comprising at least one cooling device positioned at a location between at least one heater and the seal(s) where said heater(s) are adjacent the bottoms.

15. The multiple parallel processing assembly of claim 14 wherein said cooling device is located near to the point of engagement between the tops and the bottoms.

16. The multiple parallel processing assembly of claim 1 further comprising a locking device engaging both the first support and the second support.

17. The multiple parallel processing assembly of claim 1 further comprising a plurality of sensors extending into the plurality of independent chambers.

18. The multiple parallel processing assembly of claim 17 wherein the sensors are temperature measuring sensors.

19. The multiple parallel processing assembly of claim 1 further comprising at least one temperature controlling device adjacent the plurality of bottoms.

20. The multiple parallel processing assembly of claim 19 wherein the temperature controlling device is selected from the group consisting of a heating device and a cooling device.

21. A method for conducting multiple parallel processes comprising:

a) containing a plurality of materials within a plurality of corresponding vessels, each vessel having an open end and a fluid permeable end;

b) containing the plurality of vessels within a plurality of corresponding bottoms, each bottom having a closed end and an open end, said plurality of bottoms supported by a first support;

c) sealing, simultaneously, at least two of the open ends of the plurality of bottoms with corresponding tops supported by a second support to form multiple sealed independent chambers each multiple sealed independent chamber housing the corresponding vessel containing material;

d) introducing at least one fluid to each sealed independent chamber to contact the materials contained therein; and

e) withdrawing at least one effluent from each independent chamber.

22. The method of claim 21 further comprising introducing an additional fluid to at least one independent chamber.

23. The method of claim 22 wherein the additional fluid is introduced at a point in the process after the fluid has contacted the materials.

24. The method of claim 21 further comprising individually adjusting and controlling processing parameters for each independent chamber.

25. The method of claim 21 wherein a vessel effluent is generated through the contacting of the fluid and the materials and further comprising processing the vessel effluent before the withdrawing at least one effluent from each independent chamber.

26. The method of claim 21 further comprising opening, simultaneously, at least two of the multiple sealed reaction chambers by removing at least two of the tops from the corresponding open ends of the bottoms.

27. The method of claim 21 further comprising heating at least a portion of at least one of the independent chambers.

28. The method of claim 26 further comprising removing the corresponding vessels from those bottoms having the tops removed.