Bicyclonucleoside and oligonucleotide analogue
First Claim
Patent Images
1. A nucleoside analogue of the following formula (I):
- where B is an analogue of pyrimidine or purine nucleic acid base, and X and Y are identical or different, and each represents a hydrogen atom, an alkyl group, an alkenyl group an alkynyl group, a cycloalkyl group, an aralkyl group, an aryl group, an acyl group, or a silyl group or a phosphoramidite.
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Abstract
An oligo- or polynucleotide analogue having one or more structures of the general formula
where B is a pyrimidine or purine nucleic acid base, or an analogue thereof,
is disclosed. The use of this analogue provides an oligonucleotide analogue antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized.
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Citations
5 Claims
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1. A nucleoside analogue of the following formula (I):
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where B is an analogue of pyrimidine or purine nucleic acid base, and X and Y are identical or different, and each represents a hydrogen atom, an alkyl group, an alkenyl group an alkynyl group, a cycloalkyl group, an aralkyl group, an aryl group, an acyl group, or a silyl group or a phosphoramidite. - View Dependent Claims (2, 3)
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4. An oligonucleotide or polynucleotide analogue having one or more structures of the formula (Ia):
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where B is an analogue of a pyrimidine or purine nucleic acid base.
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5. An oligonucleotide or polynucleotide analogue of the formula (II):
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where B1 and B are identical or different, and each represents an analogue of pyrimidine or purine nucleic acid base, R is a hydrogen acorn, a hydroxyl group, a halogen atom, or an alkoxy group, W1 and W2 are identical or different, and each represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aralkyl group, an aryl group, an acyl group, a silyl group, a phosphoric acid residue, a naturally occurring nucleoside or a synthetic nucleoside bound via a phosphodiester bond, or an oligonucleotide or polynucelotide containing the nucleotide, n1 or n2 n are identical or different, and each denotes an integer of 0 to 50, and n3 is an integer of 1-50, provided that n1 and n2 n are not both zero, and that not all of the n2 are zero at the same time and when n1 and/or n2 are or is 2 or more, B1 and B need nor be identical, and R need not be identical.
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Specification