Non-invasive method of determining absolute intracranial pressure
First Claim
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1. A method of determining absolute intracranial pressure (ICP) in a patient, comprising the steps of:
- monitoring skull expansion of the patient as a function of time;
inducing changes in ICP in the patient;
measuring blood pressure of the patient at a time when said skull expansion is approximately zero during said step of inducing wherein said blood pressure at said time is indicative of a reference ICP value;
causing a known change in ICP in the patient after said time;
measuring a change in said skull expansion of the patient associated with said known change in ICP; and
determining a skull expansion calibration factor, wherein the absolute ICP is a function of said reference ICP value, said measured change in skull expansion and said skull expansion calibration factor.
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Abstract
A method is presented for determining absolute intracranial pressure (ICP) in a patient. Skull expansion is monitored while changes in ICP are induced. The patient'"'"'s blood pressure is measured when skull expansion is approximately zero. The measured blood pressure is indicative of a reference ICP value. Subsequently, the method causes a known change in ICP and measures the change in skull expansion associated therewith. The absolute ICP is a function of the reference ICP value, the known change in ICP and its associated change in skull expansion, and a measured change in skull expansion.
74 Citations
37 Claims
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1. A method of determining absolute intracranial pressure (ICP) in a patient, comprising the steps of:
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monitoring skull expansion of the patient as a function of time;
inducing changes in ICP in the patient;
measuring blood pressure of the patient at a time when said skull expansion is approximately zero during said step of inducing wherein said blood pressure at said time is indicative of a reference ICP value;
causing a known change in ICP in the patient after said time;
measuring a change in said skull expansion of the patient associated with said known change in ICP; and
determining a skull expansion calibration factor, wherein the absolute ICP is a function of said reference ICP value, said measured change in skull expansion and said skull expansion calibration factor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
coupling an acoustic signal to a first location on the patient'"'"'s skin adjacent the skull of the patient;
detecting said acoustic signal at a second location on the patient'"'"'s skin adjacent the skull of the patient; and
measuring a phase difference between said acoustic signal so-coupled at said first location and said acoustic signal so-detected at said second location, wherein said phase difference is indicative of said skull expansion.
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3. A method according to claim 2 further comprising the step of applying pressure to the patient'"'"'s skin at each of said first location and said second location prior to said steps of coupling and detecting, wherein pulsatile blood perfusion at said first location and said second location is reduced.
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4. A method according to claim 2 wherein said first location and said second location are approximately diametrically-opposed to one another on either side of the skull of the patient.
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5. A method according to claim 2 wherein said first location and said second location are approximately the same location.
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6. A method according to claim 1 wherein said step of inducing comprises the step of manipulating the patient in a mechanical fashion.
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7. A method according to claim 1 wherein said step of inducing comprises the step of manipulating the patient in a chemical fashion.
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8. A method according to claim 1 wherein said step of causing comprises the step of manipulating the patient in a mechancal fashion.
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9. A method according to claim 1 wherein said step of causing comprises the step of manipulating the patient in a chemical fashion.
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10. A method of determining absolute ICP in a patient, comprising the steps of:
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monitoring skull expansion of the patient as a function of time, wherein said skull expansion is defined in terms of a length l of a path traversing at least a portion of the skull of the patient;
inducing changes in ICP in the patient;
measuring blood pressure of the patient at a time when said skull expansion is approximately zero during said step of inducing wherein said blood pressure at said time is indicative of a venous bed pressure of the patient, and wherein said venous bed pressure at said time is equal to a reference ICP value ICPREF;
causing a known change Δ
ICP in ICP in the patient after said time;
measuring a change Δ
l in said path associated with said known change in ICP; and
determining a skull expansion calibration factor, wherein the absolute ICP is equal to - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of determining absolute ICP in a patient, comprising the steps of:
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coupling an acoustic signal to a first location on the patient'"'"'s skin adjacent the skull of the patient;
detecting said acoustic signal at a second location on the patient'"'"'s skin adjacent the skull of the patient;
measuring a phase difference between said acoustic signal so-coupled at said first location and said acoustic signal so-detected at said second location, wherein said phase difference is indicative of skull expansion of the patient;
repeating said steps of coupling, detecting, and measuring for a period of time;
inducing changes in ICP in the patient during said period of time;
determining a time during said time period when said phase difference is approximately zero;
measuring blood pressure of the patient at said time, wherein said blood pressure at said time is indicative of a reference ICP value;
causing a known change in ICP in the patient after said time;
measuring a change in said skull expansion of the patient associated with said known change in ICP; and
determining a skull expansion calibration factor, wherein the absolute ICP is a function of said reference ICP value, said measured change in skull expansion, and said skull expansion calibration factor. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
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27. A method of determining absolute ICP in a patient, comprising steps for:
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monitoring skull expansion;
inducing changes in ICP;
determining a reference ICP; and
determining a skull expansion calibration factor, wherein absolute ICP is a function of said reference ICP, said skull expansion factor, and a measured change in skull dimension. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
causing a known change in ICP in the patient; and
measuring the change in skull expansion associated with said known change in ICP.
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30. A method according to claim 29 wherein each of said steps for monitoring skull expansion and measuring said change in skull expansion comprises the steps of:
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coupling an acoustic signal to a first location on the patient'"'"'s skin adjacent the skull of the patient;
detecting said acoustic signal at a second location on the patient'"'"'s skin adjacent the skull of the patient; and
measuring phase differences between said acoustic signal so-coupled at said first location and said acoustic signal so-detected at said second location, wherein said phase differences are indicative of said skull expansion.
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31. A method according to claim 30 further comprising the step of applying pressure to the patient'"'"'s skin at each of said first location and said second location prior to said steps of coupling and detecting, wherein pulsatile blood perfusion at said first location and said second location is reduced.
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32. A method according to claim 30 wherein said first location and said second location are approximately diametrically-opposed to one another on either side of the skull of the patient.
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33. A method according to claim 30 wherein said first location and said second location are approximately the same location.
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34. A method according to claim 27 wherein said step for inducing comprises the step of manipulating the patient in a mechanical fashion.
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35. A method according to claim 27 wherein said step for inducing comprises the step of manipulating the patient in a chemical fashion.
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36. A method according to claim 29 wherein said step for causing comprises the step of manipulating the patient in a mechanical fashion.
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37. A method according to claim 29 wherein said step for causing comprises the step of manipulating the patient in a chemical fashion.
Specification