Microchip reservoir devices and facilitated corrosion of electrodes

• US 6,773,429 B2
• Filed: 10/11/2001
• Issued: 08/10/2004
• Est. Priority Date: 10/11/2000
• Status: Expired due to Term

• Current Assignee: DARE MB Incorporated
• Original Assignee: MicroCHIPS Inc.
• Inventors: Feakes, Christina M., Santini, John T. Jr., Sheppard, Norman F. Jr.
• Primary Examiner(s): Mendez, Manuel
• Assistant Examiner(s): Han, Mark K
• Application Number:
  US09/975,786
• Publication Number:
  US 20020138067A1
• Time in Patent Office: 1,034 Days
• Field of Search: 604/890.1, 604/891.1, 604/892.1, 604/65, 604/131, 600/309, 600/345, 600/347, 600/348, 600/365
• US Class Current: 604/891.1
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

Methods and devices are provided for enhancing corrosion of an electrode in a biocompatible fluid. The method comprises (1) placing a primary electrode and a counter electrode in an electroconductive biocompatible fluid to form an electrochemical cell; and (2) applying a time-varying potential, through the electrochemical cell, to the primary electrode. In a preferred embodiment, the primary electrode is metal and comprises a reservoir cap of a microchip device for the release of molecules or exposure of device reservoir contents. The potential preferably is characterized by a waveform having a maximum potential effectively anodic to meet or exceed the corrosion potential of the primary electrode. Also, the minimum potential preferably is effectively cathodic to be below the value where re-deposition of metal ions on the metal electrode can substantially occur, thereby corroding the metal electrode.

Claims

1. A method for enhancing corrosion of an electrode in a biocompatible fluid, the method comprising:

placing a primary electrode and a counter electrode in contact with an electroconductive biocompatible fluid to form an electrochemical cell; and

applying a time-varying potential, through the electrochemical cell, to the primary electrode,

wherein the potential is characterized by a waveform having a maximum potential effectively anodic to meet or exceed the corrosion potential of the primary electrode, thereby corroding the primary electrode.

2. The method of claim 1, wherein the primary electrode is a metal electrode.

3. The method of claim 2, wherein the waveform has a minimum potential effectively cathodic to be below the value where re-deposition of metal ions on the metal electrode can substantially occur.

4. The method of claim 2, wherein the metal electrode comprises a metal selected from the group consisting of gold, platinum, silver, aluminum, chromium, copper, molybdenum, nickel, palladium, tantalum, titanium, tungsten, and zinc.

5. The method of claim 1, wherein the primary electrode has a thickness between about 100 and 1000 nm.

6. The method of claim 1, wherein the primary electrode comprises a reservoir cap of a microchip device for the release of molecules or exposure of device reservoir contents.

7. The method of claim 1, wherein the primary electrode comprises a polymer.

8. The method of claim 1, wherein the biocompatible fluid is a biological fluid.

9. The method of claim 8, wherein the biological fluid is selected from the group consisting of blood, plasma, lymph, extracellular matrix, interstitial fluid, serum, saliva, cerebrospinal fluid, gastrointestinal fluids, semen, and urine.

10. The method of claim 1, wherein the biocompatible fluid is selected from the group consisting of saline solutions, buffer solutions, pharmaceutical carrier solutions, and fermentation broths.

11. The method of claim 1, wherein the biocompatible fluid is in vitro.

12. The method of claim 1, wherein the biocompatible fluid is in vivo in a human or animal.

13. The method of claim 1, wherein the electrochemical cell consists of two electrodes.

14. The method of claim 1, wherein the electrochemical cell further comprises a reference electrode, which is placed in contact with the biocompatible fluid.

15. The method of claim 1, wherein the waveform is selected from the group consisting of square waves, sine waves, triangle waves, sawtooth waves, and combinations thereof.

16. A microchip device for the release or exposure of reservoir contents comprising:

a substrate having reservoirs containing contents, wherein the reservoirs have reservoir caps which comprise a primary electrode; and

controlled-potential instrumentation for applying a time-varying potential at a frequency between about 0.1 and 10,000 Hz to the primary electrode in an amount effective to corrode the primary electrode when placed in contact with an electroconductive fluid, said instrumentation comprising a counter electrode.

17. The microchip device of claim 16, wherein the time varying potential is characterized by a waveform having a maximum potential effectively anodic to meet or exceed the corrosion potential of the primary electrode.

18. The microchip device of claim 16, wherein the primary electrode is a metal electrode.

19. The microchip device of claim 18, wherein the waveform has a minimum potential effectively cathodic to be below the value where re-deposition of metal ions on the metal electrode can substantially occur.

20. The microchip device of claim 18, wherein the metal electrode comprises a metal selected from the group consisting of gold, platinum, silver, aluminum, chromium, copper, molybdenum, nickel, palladium, tantalum, titanium, tungsten, and zinc.

21. The microchip device of claim 16, wherein the primary electrode comprises a polymer.

22. The microchip device of claim 16, wherein the instrumentation for applying a time-varying potential further comprises a reference electrode.

23. The microchip device of claim 16, wherein the primary electrode has a thickness between about 100 and 1000 nm.

24. The microchip device of claim 16, wherein the reservoir contents comprise a drug, a biosensor, or a combination thereof.

25. A method of releasing or exposing the reservoir contents of a device at a site, the method comprising:

providing at a site a device which comprises

a substrate,

at least two reservoirs in the substrate,

reservoir contents in each of the at least two reservoirs,

at least two reservoir caps, each reservoir cap covering one of the at least two reservoirs and comprising a primary electrode, and

controlled-potential instrumentation, which comprises a counter electrode, for applying a time-varying potential at a frequency between about 0.1 and 10,000 Hz to the primary electrode;

placing the primary electrode and the counter electrode in contact with an electroconductive fluid to form an electrochemical cell; and

applying a time-varying potential, through the electrochemical cell, to the primary electrode to corrode the primary electrode in an amount effective to disintegrate the reservoir cap and release or expose the reservoir contents.

26. The method of claim 25, wherein the potential is characterized by a waveform having a maximum potential effectively anodic to meet or exceed the corrosion potential of the primary electrode.

27. The method of claim 25, wherein the primary electrode is a metal electrode.

28. The method of claim 27, wherein the waveform has a minimum potential effectively cathodic to be below the value where re-deposition of metal ions on the metal electrode can substantially occur.

29. The method of claim 25, wherein the electroconductive fluid is a biocompatible fluid.

30. The method of claim 29, wherein the electroconductive fluid is a biological fluid.

31. The method of claim 30, wherein the biological fluid is selected from the group consisting of blood, plasma, lymph, extracellular matrix, interstitial fluid, serum, saliva, cerebrospinal fluid, gastrointestinal fluids, semen, and urine.

32. The method of claim 25, wherein the biocompatible fluid is selected from the group consisting of saline solutions, buffer solutions, pharmaceutical carrier solutions, and fermentation broths.

33. The method of claim 25, wherein the electroconductive fluid is in vivo in a human or animal.

34. A method for enhancing corrosion of an electrode in a biocompatible fluid, the method comprising:

placing a primary electrode and a counter electrode in contact with an electroconductive biocompatible fluid to form an electrochemical cell; and

applying a time-varying potential, at a frequency between about 0.1 and 10,000 Hz, through the electrochemical cell, to the primary electrode,

wherein the potential is characterized by a waveform having a maximum potential effectively anodic to meet or exceed the corrosion potential of the primary electrode, thereby corroding the primary electrode.

35. The method of claim 34, wherein the time-varying potential is applied at a frequency between about 1 and 100 Hz.

36. The method of claim 34, wherein the time-varying potential is applied at a frequency between about 1 and 10 Hz.

37. A method of releasing or exposing the reservoir contents of a microchip device at a site, the method comprising:

providing at a site a microchip device which comprises (i) a substrate having reservoirs containing contents covered by reservoir caps which comprise a primary electrode, and (ii) means for applying a time-varying potential to the primary electrode in an amount effective to corrode the primary electrode when placed in contact with an electroconductive fluid, said means comprising a counter electrode;

placing the primary electrode and the counter electrode in contact with an electroconductive fluid to form an electrochemical cell; and

applying a time-varying potential at a frequency between about 0.1 and 10,000 Hz, through the electrochemical cell, to the primary electrode to corrode the primary electrode in an amount effective to disintegrate the reservoir cap and release or expose the reservoir contents.

38. The method of claim 37, wherein the time-varying potential is applied at a frequency between about 1 and 100 Hz.

39. The method of claim 37, wherein the time-varying potential is applied at a frequency between about 1 and 10 Hz.

40. A device for the release or exposure of reservoir contents comprising:

a substrate;

at least two reservoirs in the substrate;

reservoir contents in each of the at least two reservoirs;

at least two reservoir caps, each reservoir cap covering one of the at least two reservoirs and comprising a primary electrode; and

controlled-potential instrumentation for applying a time-varying potential to the primary electrode to corrode the primary electrode when placed in contact with an electroconductive fluid, wherein the controlled-potential instrumentation comprises a waveform generator and a potentiostat.