Enhanced intravaginal devices
First Claim
1. An intravaginal device being intravaginally insertable, retainable and withdrawable thereafter by virtue of its ability to change its geometry yet being formed solely as a molded progesterone and cyclodextrin impregnated biodegradable matrix of a biodegradable polymer selected from polyesters and starchlike polysaccharides.
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Accused Products
Abstract
A biodegradable intra vaginal device for insertion into the vagina of an animal (eg; cattle) useful for herd oestrus synchrony purposes,
the device is intra vaginally insertable, intra vaginally retainable and withdrawable by virtue of its ability to change its geometry yet is formed at least almost exclusively from a cyclodextrin and progesterone impregnated moulded matrix of a polyester polymer (eg; poly (ε-caprolactone)) or a starch-like polysaccharide polymer. There is preferably a loading of progesterone of from 0.1 to 3 gms. The surface area of the impregnated matrix is preferably from 15 to 200 cm2.
Related methods and uses also form part of the invention.
84 Citations
28 Claims
- 1. An intravaginal device being intravaginally insertable, retainable and withdrawable thereafter by virtue of its ability to change its geometry yet being formed solely as a molded progesterone and cyclodextrin impregnated biodegradable matrix of a biodegradable polymer selected from polyesters and starchlike polysaccharides.
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13. An intra vaginal device for insertion into the vagina of an animal, said device being intra vaginally insertable, intra vaginally retainable and withdrawable by virtue of its ability to change geometry yet being formed at least almost exclusively from a cyclodextrin and progesterone impregnated moulding matrix of poly (ε
- -caprolactone), the loading of progesterone being from 0.1 to 3 gms and the surface area of the impregnated matrix being from 8 to 200 cm2.
- View Dependent Claims (14, 16)
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15. A method for animal group oestrus synchrony comprising the step of utilizing an intra vaginal device, said device being intra vaginally insertable, intra vaginally retainable and withdrawable by virtue of its ability to change geometry yet being formed at least almost exclusively from a cyclodextrin and progesterone impregnated moulding matrix of poly (ε
- -caprolactone), the loading of progesterone being from 0.1 to 3 gms and the surface area of the impregnated matrix being from 8 to 200 cm2.
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17. A method of manufacturing of an intra vaginal device an for insertion into the vagina of a target species mammal, said device being or having a moulded progesterone and cyclodextrin impregnated matrix of a biodegradable polymer selected from the group of poly esters and starch like polysaccharides, the cyclodextrin being of a kind and in such amount as will enhance release and/or adsorption
which method comprises or includes the steps of including in the starting material(s) of said biodegradable polymer a distribution of both cyclodextrin and progesterone, and thereafter moulding the device or the impregnated matrix of the device therefrom.
- 22. A method of achieving in an animal (or in each animal of a group of animals) a blood serum level of progesterone of greater than 2 ng/ml for a period of at least 5 days, said method comprising inserting and retaining in the or each animal for at least the 5 day period an intra vaginal device being or having a moulded progesterone and cyclodextrin impregnated matrix of a biodegradable polymer selected from the group of poly esters and starch like polysaccharides, the cyclodextrin being of a kind and in such amount as will enhance release and/or adsorption.
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28. An intra vaginal device for insertion into the vagina of a target species mammal, said device being or having a moulded progesterone and cyclodextrin impregnated matrix of a biodegradable polymer selected from the group of poly esters and starch like polysaccharides, the cyclodextrin being of a kind and in such amount as will enhance release and/or adsorption, when made by a method which includes the steps
including in the starting material(s) of said biodegradable polymer a distribution of both cyclodextrin and progesterone, and thereafter moulding the device of the impregnated matrix of the device therefrom.
Specification