Magnetic navigation system for diagnosis, biopsy and drug delivery vehicles

• US 6,776,165 B2
• Filed: 09/12/2002
• Issued: 08/17/2004
• Est. Priority Date: 09/12/2002
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Jin, Sungho
• Primary Examiner(s): Jones, Mary Beth
• Assistant Examiner(s): Veniaminov, Nikita R
• Application Number:
  US10/242,389
• Publication Number:
  US 20040050394A1
• Time in Patent Office: 705 Days
• Field of Search: 600/114, 600/117, 600/407, 600/109, 600/101, 600/587, 600/424, 600/300, 600/474, 600/486, 600/426, 600/582, 600/302, 600/549, 600/578, 600/106, 324/507.1, 606/41, 606/130, 128/899, 128/903, 396/17, 396/183, 348/77, 348/76, 348/92, 455/100, 455/67.11, 455/67.13, 455/95, 604/113, 604/890.1, 604/891.1, 604/131, 604/327, 604/93.01, 604/244, 424/426
• US Class Current: 128/899
• CPC Class Codes: A61B 1/00158 using magnetic field
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 34/70 Manipulators specially adapted for use in surgery
• CPC Class Codes: A61B 34/73 Manipulators for magnetic surgery
• CPC Class Codes: A61B 90/361 Image-producing devices, e.g. surgical cameras
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008

Abstract

This invention discloses such a convenient navigation system and navigatable capsules which are useful for remote-controlled imaging, biopsy and programmable drug release within the body of an animal. The components of the system comprise a capsule dimensioned and shaped to move within the body. An anisotropic magnetic component is mechanically coupled to the capsule to move or orient the body in relation to an applied magnetic field, and a magnetic field generating system external of the body generates a three dimensionally oriented magnetic field within the body to move or orient capsule.

Claims

1. A system for moving a capsule within the body of an animal comprising:

a capsule dimensioned and shaped to move within the body of the animal;

mechanically coupled to the capsule, an anisotropic magnetic component to orient the capsule in relation to an applied magnetic field;

a detector to determine the location of the capsule within the body; and

a magnetic field generating system external of the body responsive to the detected location of the capsule for generating a three dimensionally oriented field within the body to move the anisotropic magnetic component and thereby the capsule within the body.

2. The system of claim 1 wherein the detector senses the position of the capsule and the feedback of the position information at every moment is utilized for controlling the magnetic field generating system to guide the capsule.

3. The system of claim 1 wherein the detector senses sidewall pressure and the feedback of the pressure information is utilized by the magnetic field generating system to minimize the pressure exerted by the capsule on the wall of the tract duct or cavity.

4. The system of claim 1 wherein the capsule is dimensioned and shaped to move within the gastro-intestinal tract of an animal.

5. The system of claim 1 wherein the capsule includes an imaging device.

6. The system of claim 1 wherein the capsule includes a biopsy device.

7. The system of claim 6 wherein the biopsy device is remotely controllable.

8. The system of claim 1 wherein the capsule includes a drug release device.

9. The system of claim 8 wherein the drug release device is remotely controllable.

10. The system of claim 1 wherein the capsule includes a source or detector of ultrasonic energy.

11. The system of claim 10 wherein the source or detector of ultrasonic energy is remotely actuable.

12. The system of claim 1 wherein the capsule includes a source or detector of thermal energy.

13. The system of claim 12 wherein the source or detector of thermal energy is remotely actuable.

14. The system of claim 1 wherein the capsule includes a source or detector of mechanical vibration.

15. The system of claim 1 wherein the source or detector of mechanical vibration is remotely actuable.