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Histone deacetylases, and uses related thereto

  • US 6,777,217 B1
  • Filed: 03/26/1996
  • Issued: 08/17/2004
  • Est. Priority Date: 03/26/1996
  • Status: Expired due to Fees
First Claim
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1. An isolated nucleic acid encoding a histone deacetylase gene family (HDx) polypeptide having a histone deacetylase activity, which HDx polypeptide comprises a ν

  • motif represented in the general formulaDIAX1NWAGGLHHAKKX2EASGFCYVNDIVX3X4ILELLKYHX5RVLYLDIDIHHGDGX6EA FYX7TDRVMTVSF (SEQ ID NO;

         13) and a χ

    motif represented in CVEX1VKX2FNX3P-X4LX5LGGGGYTX6RNVARCWTYET (SEQ ID NO;

         16), and which nucleic acid hybridizes under stringent conditions of 6.0×

    SSC at 65°

    C. to the nucleotide sequence designated in SEQ ID NO;

    1.

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