Human membrane proteins and polynucleotides encoding the same

• US 6,777,232 B1
• Filed: 10/02/2001
• Issued: 08/17/2004
• Est. Priority Date: 10/02/2000
• Status: Expired due to Fees

• Current Assignee: Lexicon Genetics, Incorporated
• Original Assignee: Lexicon Genetics, Incorporated
• Inventors: Scoville, John, Walke, D. Wade
• Primary Examiner(s): Kunz, Gary
• Assistant Examiner(s): Li, Ruixiang
• Application Number:
  US09/969,532
• Time in Patent Office: 1,050 Days
• Field of Search: 536/23.1, 536/23.5, 536/24.3, 435/320.1, 435/325, 435/252.3, 435/254.11, 435/254.2
• US Class Current: 435/325
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: C07K 14/47 from mammals

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:

9.

4. A recombinant expression vector comprising the isolated nucleic acid molecule of claim 1.

5. The recombinant expression vector of claim 4, wherein the isolated nucleic acid molecule encodes the amino acid sequence shown in SEQ ID NO:

10.

6. A host cell comprising the recombinant expression vector of claim 4.

2. An isolated nucleic acid molecule comprising a nucleotide sequence that:

(a) encodes the amino acid sequence shown in SEQ ID NO;

10; and

(b) hybridizes to the nucleotide sequence of SEQ ID NO;

9 or the complement thereof under highly stringent conditions of 0.5 M NaHPO₄, 7% sodium dodecyl sulfate (SDS) and 1 mM EDTA at 65°

C. and washing in 0.1×

SSC/0.1% SDS at 68°

C.

3. An isolated nucleic acid molecule comprising a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:

10.