Substance delivery device

• US 6,780,168 B2
• Filed: 04/09/2002
• Issued: 08/24/2004
• Est. Priority Date: 03/23/1995
• Status: Expired due to Fees

• Current Assignee: Advanced Animal Technology Limited
• Original Assignee: Advanced Animal Technology Limited
• Inventors: Jellie, Hugh Philip
• Primary Examiner(s): MAYNARD, JENNIFER J
• Application Number:
  US10/119,425
• Publication Number:
  US 20020165487A1
• Time in Patent Office: 868 Days
• Field of Search: 604/890.1, 604/891.1, 604/48, 604/500, 604/514-517, 604/57-59, 604/93.01, 604/104-107, 604/177, 604/285, 604/513, 128/832, 128/833, 128/840
• US Class Current: 604/107
• CPC Class Codes: A61D 17/002 for detecting period of heat of animals, i.e. for detecting oestrus for humans A61B10/0012
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

According to one aspect of the present invention there is provided a substance delivery device (1) capable of insertion into a body cavity of an animal, including delivery apparatus (11) capable of actively being controlled to deliver a substance to an outlet, and retention apparatus (2, 3) capable of retaining the substance delivery device within the body cavity of an animal. In one embodiment, a microprocessor (18) can be remotely programmed to enable control over the delivery device after it is placed in the animal. The microprocessor (18) can also communicate with an external device to enable the operation of the delivery device to be determined. The invention may also include sensors to monitor the environment around the delivery device, to determine when a substance should be delivered into the body.

Claims

1. A substance delivery device for delivering a substance into a body cavity of an animal into which the device is inserted, said device comprising:

a body;

a plate to be securely located at at least one end of said body;

retention means carried by said body for retaining the device within the animal'"'"'s body cavity comprising, a plurality of longitudinal elongated flexible arms connected to at least one of said body and said base plate, each of said arms being generally linear in an undeformed state and flexible to a degree to permit lying along the outside of said body for insertion into the animal body cavity, and lying forward of said body when said device is being withdrawn from the body cavity,

means operable after the device is inserted in the animal body cavity for moving said arms from the position lying along the outside of the body to extend generally radially of said body,

said arms being flexible to be foldable from the undeformed state lying along the outside of said body in a condition for insertion into the animal body cavity to a condition after insertion of the cavity wherein said arms are placed in a retaining condition by said means for moving said arms, wherein each of said arms in said cavity being capable of being bent along its length in different directions at the same time for each of said arms to be capable of contracting and conforming to changes of irregularly shaped internal surface(s) of the animal'"'"'s body cavity when the substance delivery device is in the animal'"'"'s body cavity to maintain continual contact with at least a portion of at least one of said arms lying against the surface of the body cavity for preventing passage of the device through the cavity and/or inadvertent removal and each of said arms can separately flex through substantially 180 degrees from lying in a direction generally along the length of said device body during insertion into the animal body cavity to a position lying forward of said device body when said device body is being withdrawn from the animal body cavity.

2. The substance delivery device means according to claim 1 wherein the ends of said arms distal from said body are enlarged for maintaining contact with an internal surface that defines the body cavity without effecting either or both undue pressure or damage to the internal surface.

3. The substance delivery device means according to claim 2 wherein a portion of at least one of said flexible arms adjacent said enlarged end bears against the internal surface of the animal body cavity.

4. The substance delivery device means according to claim 3 wherein at least one-third of the length of the said at least one arm bears against the surface of the animal body cavity.

5. The substance delivery device means according to claim 1 wherein said arms are of substantially greater length than the body cavity into which the substance delivery device is to be inserted.

6. The substance delivery device means according to claim 1 wherein all of said plurality of arms are of equal length.

7. The substance delivery device means according to claim 1 wherein said retention means retains the body of the substance delivery device in situ in the body cavity for at least a defined period equal to the period needed for the controlled release of a substance housed in at least one reservoir within said body of the substance delivery device.

8. Substance delivery device as claimed in claim 1 wherein the degree of flexibility of said arms along their respective lengths permits a portion of at least one of said arms distal of its end to engage a wall of the body cavity and generally conform to its shape.

9. Substance delivery device as claimed in claim 1 wherein said retention means is located at at least one end of said body.

10. Substance delivery device as claimed in claim 1 wherein said means for moving said arms moves said arms relative to said body between a position where the arms are aligned with each other and the longitudinal axis of said body both forward and rearward of said body for either or both inserting and withdrawing said device into and/or from the animal'"'"'s body cavity, and a position extending generally radially from said body for said arms to engage the walls of the cavity for retaining the device within the animal'"'"'s body cavity.

11. Substance delivery device as claimed in claim 8 wherein said means for moving said arms of said retention means are operable to move said arms relative to said body between an aligned position where said arms are aligned generally parallel to said body for either or both insertion and/or withdrawal of the substance delivery device into or from the body cavity of the animal, and a position extending from said body for said arms to engage the wall of the cavity retaining the substance delivery device within the animal'"'"'s body cavity.

12. Substance delivery device as claimed in claim 11 further wherein said moving means moves said arms to an extended position generally radial relative to said body after said device is inserted into the animal'"'"'s body cavity.

13. Substance delivery device as in claim 10 wherein said moving means comprises at least one of biasing apparatus, plunging apparatus and the compressive creep modulus of the arms themselves for moving said arms from the position lying along the outside of the body to extend generally radially of said body after the device is mounted in the animal body cavity.

14. Substance delivery device as claimed in claim 13 wherein said arms are connected to said plate and said biasing apparatus includes a resilient means to operate said base plate between a biased position when said arms of said retention means are generally aligned relative to said body, and are unbiased position when said arms are extended.

15. Substance delivery device as claimed in claim 14 further comprising means to lock the extended arms of the retaining apparatus that radiate from said base plate in a plane substantially perpendicular to the longitudinal axis of said substance delivery device body.

16. Substance delivery device as in claim 1 wherein said plurality of arms comprise at least three arms which extend radially outward in different directions from said body.

17. Substance delivery device as claimed in claim 1 wherein the cross-section of each of said plurality of arms is generally circular in shape.

18. Substance delivery device as in claim 16 wherein the distal end of each of said arms is of enlarged cross-section relative to the portion of the arm closer to said body.

19. Substance delivery device as in claim 18 wherein the distal end of each of said arms is of bulbous shape.

20. Substance delivery device as claimed in claim 1 wherein said moving means comprises the compressive creep modulus of the arms themselves for moving said arms from the position lying along the outside of the body to extend generally radially of said body after the device is mounted in the animal body cavity.

21. A method of retaining a substance delivery device within a body cavity of an animal said substance delivery device including a body capable of actively delivering a substance into the body cavity, comprising:

providing the substance delivery device with a retention apparatus including a base plate at one end of the device body, said base plate having a plurality of elongated flexible arms connected thereto;

aligning said plurality of arms to lie along the outside of said device body for insertion and withdrawal of the substance delivery device into and from the animal'"'"'s body cavity;

extending said plurality of arms from a position along the length of said body to positions generally radially relative to said body when the device is in the animal'"'"'s body cavity, and

locking said plurality of arms in the radially extended position such that the arms contact the internal surface(s) of the cavity, each of said arms being substantially flexible along its length and capable of being bent in different directions at the same time along its length, the degree of flexibility of said arms of being commensurate with that required to enable the arms to contact and engage along the length thereof irregular shaped surfaces of the animal body cavity and accommodate compressive forces from surfaces of the animal body cavity on and along the arms without the arms.

22. A method as in claim 21 further comprising the step of withdrawing the device from the animal'"'"'s body cavity by folding said arms during withdrawal to be in a position generally formed of said body.

23. A substance delivery device for delivering a substance into a body cavity of an animal into which the device is inserted, said device comprising:

an elongated body;

a retention means comprising a one piece molded base plate member of a resilient material including a plurality of flexible elongated arms spaced around said base plate and which arms lie outside and along the length of said body for the delivery device to be inserted into the animal body cavityl; and

an extending mechanism operable with said body in the animal body cavity operating to extend all of said arms from said base plate from the position lying along the length of said body and to hold all of said arms generally radially of the longitudinal axis of said body, each of said arms being generally linear in an undeformed state and also being substantially flexible along its length to be capable of being bent in any direction for contacting and conforming to changes in shape of the internal surface(s) of the animal body cavity, the degree of flexibility of said arms of being commensurate with that required to enable the arms to contact and engage along the length thereof irregular shaped surfaces of the animal body cavity and accommodate compressive forces from surfaces of the animal body cavity on and alone the arms without the arms.

24. A substance delivery device as in claim 23 wherein said one piece molded member is part of said body with said arms molded thereon.

25. A substance delivery device as in claim 24 wherein said extending mechanism includes a locking means to place and hold said plurality of arms in the position extending generally radially of said body longitudinal axis.

26. A substance delivery device as in claim 25 wherein said locking means comprises a collar movable relative to said body to engage and move said flexible arms to the radially extending position.

27. A substance delivery device as in claim 23 wherein said one piece molded member comprises a base plate that is transverse to the longitudinal axis of said body with said flexible arms molded thereto.

28. A substance delivery device as in claim 23 wherein each of said arms has a cross-section that is curved.

29. A substance delivery device as in claim 28 wherein the cross-section of each of said arms is circular.

30. A substance delivery device as in claim 23 wherein the flexibility of said arms is sufficient to permit them to be bent to be forward of said body when said body is being withdrawn from the cavity.