Intradermal delivery device

• US 6,780,171 B2
• Filed: 04/02/2002
• Issued: 08/24/2004
• Est. Priority Date: 04/02/2002
• Status: Expired due to Term

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Wilkinson, Bradley M., Gabel, Jonathan B., Hwang, Charles G.
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Maynard, Jennifer J
• Application Number:
  US10/112,757
• Publication Number:
  US 20030187395A1
• Time in Patent Office: 875 Days
• Field of Search: 604/890.1, 604/19-22, 604/27, 604/30, 604/48, 604/93.01, 604/131, 604/132, 604/140, 604/141, 604/143, 604/145, 604/148, 604/151, 604/153, 604/154, 604/164.04, 604/164.08, 604/173, 604/174, 604/179-181, 604/185, 604/197, 604/200-205, 604/212, 604/239, 604/244, 604/246, 604/264, 604/272, 604/289, 604/294, 604/304-308
• US Class Current: 604/181
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2005/14506 mechanically driven, e.g. spring or clockwork
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/14248 of the skin patch type

Abstract

A delivery device for delivering a substance intradermally into the skin of a patient including a housing for contacting the surface of the skin and a disposable cartridge to be received in the housing. The cartridge includes an internal reservoir containing a substance to be delivered to the patient, a plurality of micro skin penetrating members and a fluid channel extending between the micro skin penetrating members and the reservoir. The housing includes a bottom wall with a central opening and a cover member. The cartridge is positioned in the housing with the micro skin penetrating members extending through the central opening of the bottom wall and positioned on the surface of the skin of a patient. The cover is closed onto the cartridge to dispense the substance from the cartridge through the micro skin penetrating members and into or through the skin of the patient.

Claims

1. An intradermal delivery device comprising:

a housing;

a cartridge removably received in said housing, said cartridge defining an internal reservoir adapted to contain a substance to be delivered to a patient;

a dispensing member comprising a spring member for contacting said cartridge operable to apply a dispensing pressure to said cartridge wherein said cartridge is collapsible by said dispensing member and said dispensing member is hinged to said housing and is pivotable between an open and closed position, said dispensing member contacting said cartridge when in said closed position to apply said dispensing pressure to said cartridge;

at least one skin penetrating member, said skin penetrating member having a length sufficient to penetrate the surface of the skin of said patient, said skin penetrating member adapted to be placed in fluid communication with said reservoir for delivering a substance in said reservoir to the patient.

2. The delivery device of claim 1, wherein said skin penetrating member is coupled to said cartridge, said skin penetrating member having a base, an outer end and a passage extending between said base and said outer end, and wherein said base is adapted to be placed in fluid communication with said reservoir.

3. The delivery device of claim 1, wherein said housing has a top edge, a bottom edge and an internal chamber dimensioned to receive said cartridge, said housing further including a coupling member for coupling said device to the skin of the patient.

4. The delivery device of claim 3, wherein said coupling member on said housing is a strap for coupling to the skin of the patient.

5. The delivery device of claim 1, wherein said dispensing member further comprises a cover hinged to said housing, said spring member having a first end fixed to said cover and a second free end.

6. The delivery device of claim 5, wherein said free end of said spring includes an indicator visible through said cover when said spring is in a relaxed position and is not visible through said cover when said spring member is stressed.

7. The delivery device of claim 6, wherein said cover includes a window for viewing said indicator when said spring is in a relaxed position.

8. The delivery device of claim 1, further comprising an indicator for indicating that said substance is dispensed from said cartridge.

9. The delivery device of claim 1, wherein said skin penetrating member has a length of about 50 microns to about 5000 microns.

10. The delivery device of claim 1 wherein said skin penetrating member is one of an array of skin penetrating members, each adapted to be placed in fluid communication with said reservoir.

11. The delivery device of claim 9, wherein said skin penetrating member has a length of about 500 microns to about 3000 microns.

12. The delivery device of claim 11, wherein said skin penetrating member has a length of about 500 microns to about 1000 microns.

13. An intradermal delivery device comprising:

a housing;

a cartridge removably received in said housing, said cartridge defining an internal reservoir adapted to contain a substance to be delivered to a patient;

at least one skin penetrating member, said skin penetrating member having a length sufficient to penetrate the surface of the skin of said patient, said skin penetrating member adapted to be placed in fluid communication with said reservoir for delivering a substance in said reservoir to the patient;

a piercing member for piercing a wall of said reservoir to allow fluid to flow from said reservoir to said skin penetrating member;

and a cover member defining a dispensing member for said cartridge, said cover member being pivotally connected to said housing and being pivotal between an open position and a closed position, said cover member applying a dispensing pressure to said cartridge when said cover is in said closed position with said cartridge received in said housing wherein said cover member includes a cam surface oriented for actuating said piercing member to pierce said wall of reservoir when said cover is in said closed position.

14. The delivery device of claim 13 wherein said cartridge defines a fluid passageway between said skin penetrating member and the wall of said reservoir where it is pierced by said piercing member.