Delivery of stimulants through an inhalation route
First Claim
1. A composition for delivery of ephedrine or fenfluramine comprising a condensation aerosola) formed by volatilizing epredrine or fenfluramine under conditions effective to produce a heated vapor of the drug and condensing the heated vapor of the ephedrine or fenfluramine to form condensation aerosol particles:
- b) wherein said condensation aerosol particles are characterized by less than 5% ephendrine or fenfluramine degradation products, and c) the aerosol has an MMAD less than 3 microns.
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Accused Products
Abstract
The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing ephedrine or fenfluramine that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of ephedrine or fenfluramine. In a method aspect of the present invention, one of ephedrine or fenfluramine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of ephedrine or fenfluramine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering ephedrine or fenfluramine through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of ephedrine or fenfluramine; and, b) a device that forms an ephedrine or fenfluramine containing aerosol from the composition, for inhalation by the mammal.
114 Citations
14 Claims
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1. A composition for delivery of ephedrine or fenfluramine comprising a condensation aerosol
a) formed by volatilizing epredrine or fenfluramine under conditions effective to produce a heated vapor of the drug and condensing the heated vapor of the ephedrine or fenfluramine to form condensation aerosol particles: -
b) wherein said condensation aerosol particles are characterized by less than 5% ephendrine or fenfluramine degradation products, and c) the aerosol has an MMAD less than 3 microns. - View Dependent Claims (2, 3, 4, 5)
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6. A method of producing an ephedrine or fenfluramine in an aerosol form comprising:
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a) volatilizing ephedrine or fenfluramine under conditions effective to produce a heated vapor of the drug, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the ephedrine or fenfluramine comprising less than 5% ephedrine or fenfluramine degradation products and an aerosol having an MMAD less than 3 microns. - View Dependent Claims (7, 8, 9, 10, 11, 12)
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13. A composition for delivery of a stimulant comprising a condensation aerosol
a) formed by volatilizing a stimulant under conditions effective to produce a heated vapor of the stimulant and condensing the treated vapor of the stimulant to form condensation aerosol particles; -
b) wherein said condensation aerosol particles are characterized by less than 5% stimulant degradation products, and c) the aerosol has an MMAD less than 3 microns.
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14. A method of producing a stimulant in an aerosol form comprising:
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a) volatilizing a stimulant under conditions effective to produce a heated vapor of the stimulant, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the stimulant comprising less than 5% stimulant degradation products and an aerosol having an MMAD less than 3 microns.
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Specification