Sensor material, sensor and detection method for bio-substance

• US 6,780,647 B2
• Filed: 10/01/2001
• Issued: 08/24/2004
• Est. Priority Date: 12/06/2000
• Status: Expired due to Fees

• Current Assignee: Fuji Xerox Company Limited (Fujifilm Holdings Corporation)
• Original Assignee: Fuji Xerox Company Limited (Fujifilm Holdings Corporation)
• Inventors: Akashi, Ryojiro, Fujiwara, Shoichiro, Mikami, Masato, Uematsu, Takashi
• Primary Examiner(s): Snay, Jeffrey R.
• Application Number:
  US09/966,079
• Publication Number:
  US 20020068019A1
• Time in Patent Office: 1,058 Days
• Field of Search: 422/55, 422/56, 422/57, 422/82.06, 422/82.09, 436/531, 436/532, 436/533, 436/534, 436/535, 436/164, 436/169
• US Class Current: 436/169
• CPC Class Codes: C12Q 1/54 involving glucose or galactose
• CPC Class Codes: C12Q 1/58 involving urea or urease
• CPC Class Codes: G01N 2021/7723 Swelling part, also for adsorption sensor, i.e. without chemical reaction
• CPC Class Codes: G01N 21/47 Scattering, i.e. diffuse reflection G01N21/25, G01N21/41 take precedence G01N21/55 takes precedence
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G01N 2333/904 acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• CPC Class Codes: G01N 2333/908 acting on hydrogen peroxide as acceptor (1.11)

Abstract

Provided is a sensor material including at least a stimulus-responsive high polymer gel, a bio-substance-responsive material and a light modulation material. A sensor having at least the sensor material and an optical waveguide is also provided. Furthermore, provided are a detection method for a bio-substance using the sensor material in which a change in tone is detected on the basis of swelling or shrinking of the stimulus-responsive high polymer gel, and a detection method for transmitting light using a sensor material in which transmitting light is detected on the basis of swelling or shrinking of the stimulus-responsive high polymer gel.

Claims

1. A sensor material comprising at least a stimulus-responsive high polymer gel, a bio-substance-responsive material, and a colored pigment.

2. The sensor material according to claim 1, wherein at least the bio-substance-responsive material and the colored pigment are present inside the stimulus-responsive high polymer gel.

3. The sensor material according to claim 1, wherein the colored pigment is present inside the stimulus-responsive high polymer gel while the bio-substance-responsive material is present outside the stimulus-responsive high polymer gel.

4. The sensor material according to claim 1, wherein the stimulus-responsive high polymer gel swells or shrinks according to a concentration of the bio-substance.

5. The sensor material according to claim 1, wherein a concentration of the colored pigment included in the stimulus-responsive high polymer gel is equal to or higher than a saturated absorption concentration or a saturated scattering concentration when the stimulus-responsive high polymer gel shrinks.

6. The sensor material according to claim 1, wherein a ratio of a volume of the stimulus-responsive high polymer gel in swelling state to a volume of the stimulus-responsive high polymer gel in shrinking state is 5 or more.

7. A sensor comprising at least the sensor material according to claim 1 and an optical waveguide.

8. A detection method for a bio-substance using the sensor material according to claim 1, comprising the step of detecting a change in tone on the basis of swelling or shrinking of the stimulus-responsive high polymer gel.

9. A detection method for a bio-substance using the sensor material according to claim 1, comprising the step of detecting a transmitting light therethrough on the basis of swelling or shrinking of the stimulus-responsive high polymer gel.