Medicament respiratory delivery device and cartridge
First Claim
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1. A medicament respiratory delivery device, comprising:
- a housing comprised of two opposed thermoformed bonded thermoplastic sheets, said sheets having formed therebetween a chamber, an inlet communicating with said chamber, a pressure actuator having an outlet communicating with said inlet of said chamber and an outlet communicating with said chamber opposite said inlet of said chamber; and
a medicament cartridge in said chamber encapsulated by said sheets, said medicament cartridge including a body having opposed first and second ends, a passage extending through said body through said opposed first and second ends aligned with said inlet and outlet of said housing, a medicament in said passage, and burstable membranes covering said first and second ends of said passage, whereby delivery of fluid under pressure from said pressure actuator through said inlet of said housing ruptures said burstable membranes and delivers said medicament to said outlet of said housing, wherein said delivered medicament has a fine particle fraction of at least 18.5%.
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Abstract
A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing, such that fluid delivered to the inlet ruptures the membranes, entrains medicament contained within the cartridge passage which is delivered to the patient'"'"'s respiratory system through the outlet.
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Citations
11 Claims
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1. A medicament respiratory delivery device, comprising:
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a housing comprised of two opposed thermoformed bonded thermoplastic sheets, said sheets having formed therebetween a chamber, an inlet communicating with said chamber, a pressure actuator having an outlet communicating with said inlet of said chamber and an outlet communicating with said chamber opposite said inlet of said chamber; and
a medicament cartridge in said chamber encapsulated by said sheets, said medicament cartridge including a body having opposed first and second ends, a passage extending through said body through said opposed first and second ends aligned with said inlet and outlet of said housing, a medicament in said passage, and burstable membranes covering said first and second ends of said passage, whereby delivery of fluid under pressure from said pressure actuator through said inlet of said housing ruptures said burstable membranes and delivers said medicament to said outlet of said housing, wherein said delivered medicament has a fine particle fraction of at least 18.5%. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of delivering a medicament to the respiratory system of a user, comprising the following steps:
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providing a medicament respiratory delivery device including a cartridge having opposed inlet and outlet ends, a passage containing medicament extending through said cartridge and through said inlet and outlet ends, a thin burstable membrane having a burst pressure of between 1.2 and 10 atmospheres sealing said passage at said outlet end of said cartridge, and a manually acitivated fluid delivery device communicating with said inlet end of said cartridge; and
i activating said manually activated fluid delivery device to deliver fluid under pressure to said inlet end of said cartridge, rupturing said thin burstable membrane, entraining said medicament in said fluid, and delivering said medicament to the respiratory system of the user, wherein said delivered medicament has a fine particle fraction of at least 18.5%. - View Dependent Claims (8, 9, 10, 11)
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Specification