Flexible vascular inducing implants and methods

• US 6,786,929 B2
• Filed: 11/21/2001
• Issued: 09/07/2004
• Est. Priority Date: 09/30/1998
• Status: Expired due to Fees

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Choh, Richard T., Weiser, Michael F., Gambale, Richard A., Forcucci, Stephen J., Forde, Sean
• Primary Examiner(s): Robert, Eduardo C.
• Application Number:
  US09/990,644
• Publication Number:
  US 20020032476A1
• Time in Patent Office: 1,021 Days
• Field of Search: 623/11.11, 128/898
• US Class Current: 623/11.11
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61F 2/94 Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

Claims

1. A method of promoting angiogenesis in the myocardium comprising:

generating thrombus in the myocardium to stimulate angiogenesis by placing at least one implant in the myocardium, wherein the implant comprises a pump.

2. A method of promoting angiogenesis in the myocardium as defined in claim 1 wherein an angiogenic substance is associated with the pump.

3. A method of promoting angiogenesis in the myocardium as defined in claim 1 wherein the pump contains a thrombus.

4. A method of promoting angiogenesis in the myocardium of a patient comprising:

removing thrombosed blood from the patient;

implanting the thrombus in the myocardium of the patient.

5. A method of promoting angiogenesis in the myocardium of a patient as defined in claim 4 wherein the thrombus becomes associated with an implant device and the device is implanted in the myocardium.