Prevention and treatment of amyloidogenic disease
First Claim
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1. A method of prophylactically or therapeutically treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an Aβ
peptide and a 3 De-O-acylated monophosphoryl lipid A (MPL) adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide and thereby prophylactically or therapeutically treat the disease in the patient.
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer'"'"'s disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
187 Citations
43 Claims
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1. A method of prophylactically or therapeutically treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an Aβ
peptide and a 3 De-O-acylated monophosphoryl lipid A (MPL) adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide and thereby prophylactically or therapeutically treat the disease in the patient.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
- in a patient, comprising;
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36. A pharmaceutical composition effective to induce an immunogenic response against Aβ
- in a patient comprising an Aβ
peptide and a 3 De-O-acylated monophosphoryl lipid A (MPL) adjuvant. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43)
- in a patient comprising an Aβ
Specification