Prevention and treatment of amyloidogenic disease
First Claim
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1. A method of preventing or treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an Aβ
peptide and an adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide, the adjuvant enhancing the immune response to the Aβ
peptide, and thereby prevent or treat the disease in the patient.
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer'"'"'s disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
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Citations
24 Claims
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1. A method of preventing or treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an Aβ
peptide and an adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide, the adjuvant enhancing the immune response to the Aβ
peptide, and thereby prevent or treat the disease in the patient.- View Dependent Claims (2, 3, 4, 5, 6, 7, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 23, 24)
- in a patient, comprising;
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8. A method of preventing or treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an Aβ
peptide in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide and thereby prevent or treat the disease in the patient, wherein the dose of Aβ
peptide administered to the patient at least 50 μ
g.- View Dependent Claims (9)
- in a patient, comprising;
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22. A method of preventing or treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an Aβ
peptide in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide and thereby prevent or treat the disease in the patient; and
monitoring the patient for the immune response, wherein the monitoring comprises detecting antibodies having Aβ
peptide binding specificity.
- in a patient, comprising;
Specification