Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
First Claim
1. A transoral endoscopic gastroesophageal flap valve restoration assembly, the assembly comprising:
- a transparent mold configured to receive stomach tissue;
a tissue shaper that non-invasively grips and urges stomach tissue into the mold;
at least one tissue fixation device;
a tissue fixation device dispenser configured to deploy the at least one tissue fixation device in to molded stomach tissue; and
a longitudinal member, a portion of which is arranged to carry the mold, the tissue shaper, and the dispenser transorally into a stomach, the mold and dispenser being cooperatively arranged such that when the at least one tissue fixation device is deployed from the dispenser into the molded stomach tissue and the molded stomach tissue released from the mold, the molded tissue has a shape substantially similar to a gastroesophageal flap.
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Accused Products
Abstract
The invention provides a device, assembly, and method for transoral endoscopic restoration of a gastroesophageal flap valve. The invention also provides a self-steering and self-closing tissue fixation device for tissue fixation, and an invaginator device for gripping and maneuvering tissue. The restoration device includes a longitudinal member arranged for transoral placement into a stomach, a tissue shaper carried on the longitudinal member that causes stomach tissue to assume a shape related to a gastroesophageal flap, and a tissue fixation device that maintains the shaped stomach tissue in a shape approximating a gastroesophageal flap. The tissue shaper may include a mold. The device may include the invaginator device for gripping and maneuvering esophageal tissue to aid restoration of the gastroesophageal flap, and may include the tissue fixation device.
263 Citations
48 Claims
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1. A transoral endoscopic gastroesophageal flap valve restoration assembly, the assembly comprising:
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a transparent mold configured to receive stomach tissue;
a tissue shaper that non-invasively grips and urges stomach tissue into the mold;
at least one tissue fixation device;
a tissue fixation device dispenser configured to deploy the at least one tissue fixation device in to molded stomach tissue; and
a longitudinal member, a portion of which is arranged to carry the mold, the tissue shaper, and the dispenser transorally into a stomach, the mold and dispenser being cooperatively arranged such that when the at least one tissue fixation device is deployed from the dispenser into the molded stomach tissue and the molded stomach tissue released from the mold, the molded tissue has a shape substantially similar to a gastroesophageal flap. - View Dependent Claims (2, 3, 4)
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5. A transoral endoscopic gastroesophageal flap valve restoration assembly, the assembly comprising:
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a longitudinal member, a portion of which is arranged for transoral placement into a stomach, and that carries a mold having a shape related to a gastroesophageal flap, the mold being arranged to move from a first configuration to a second configuration in response to a change in pressure in a portion of the mold;
a tissue shaper that non-invasively grips and urges stomach tissue into the mold; and
a tissue fixation device that maintains the molded stomach tissue in a shape approximating a gastroesophageal flap. - View Dependent Claims (6)
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7. A transoral endoscopic gastroesophageal flap valve restoration assembly, the assembly comprising:
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a mold having a molding surface that encompasses an arc of not more than 330-degrees;
a tissue shaper that non-invasively grips and urges stomach tissue into the mold;
at least one tissue fixation device;
a tissue fixation device dispenser configured to deploy the at least one tissue fixation device in to molded stomach tissue; and
a longitudinal member, a portion of which is arranged to carry the mold, the tissue shaper, and the dispenser transorally into a stomach, the mold and dispenser being cooperatively arranged such that when the at least one tissue fixation device is deployed from the dispenser into the molded stomach tissue and the molded stomach tissue released from the mold, the molded tissue has a shape substantially similar to a gastroesophageal flap. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A transoral endoscopic gastroesophageal flap valve restoration assembly, the assembly comprising:
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a longitudinal member, a portion of which is arranged for transoral placement into a stomach, and that carries a mold having a shape related to a gastroesophageal flap;
a tissue shaper that non-invasively grips and urges stomach tissue into the mold, the tissue shaper including a structure that moves from a first position arranged to grip tissue to a second position arranged to urge tissue into the mold; and a member carried on the structure and having a plurality of vacuum orifices on a surface arranged to grip tissue; and
a tissue fixation device that maintains the molded stomach tissue in a shape approximating a gastroesophageal flap. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A transoral endoscopic gastroesophageal flap valve restoration assembly, comprising:
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a longitudinal member, a portion of which is arranged for transoral placement into a stomach, that carries a mold having a shape related to a gastroesophageal flap;
a tissue mover that non-invasively grips with a vacuum and urges stomach tissue into the mold;
an invaginator having a tissue gripper to vacuum grip esophageal tissue and allow a force to be imparted to the vacuum gripped esophageal tissue, wherein the invaginator has a first configuration for transoral placement in the esophagus, and a second configuration for vacuum engagement with the esophageal tissue, and further wherein the invaginator is arranged to move from the first configuration to the second configuration in response to a change in pressure in a portion of the invaginator; and
a tissue fixation device that maintains the molded stomach tissue in a shape approximating a gastroesophageal flap. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. An invaginator device comprising:
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a longitudinal member having a portion configured for endoluminal placement within a hollow body structure; and
a tissue-gripper carried on the portion of the longitudinal member and including a vacuum opening that vacuum grips an interior surface of the hollow body structure from within the hollow body structure and allows a force to be imparted on the hollow body structure substantially parallel to the vacuum gripped surface, wherein the tissue-gripper is arranged to move from a first configuration to a second configuration in response to a change in pressure in a portion of the device. - View Dependent Claims (41, 42, 43, 44, 45, 46, 47, 48)
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Specification