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Integrated monolithic microfabricated electrospray and liquid chromatography system and method

  • US 6,790,354 B1
  • Filed: 10/27/2000
  • Issued: 09/14/2004
  • Est. Priority Date: 09/17/1998
  • Status: Expired due to Term
First Claim
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1. An electrospray device comprising:

  • a monolithic substrate having a plurality of entrance orifices on an injection side and a plurality of nozzles on an ejection surface on an opposite planar side from the injection side, a plurality of channels each extending continuously through the monolithic substrate in communication with one of the plurality of entrance orifices and a corresponding one of the plurality of nozzles, and a region surrounding each nozzle recessed from the ejection surface;

    said plurality of nozzles disposed in an array for ejecting a plurality of analytes at a mass spectrometry device interface; and

    a plurality of electrodes for the application of electric potentials for generating and controlling an electric field at each nozzle to direct the ejection of the analytes from the nozzles within an acceptance region of the mass spectrometry device.

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