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Methods of identifying and ADP-glucose receptor ligand, agonist or antagonist

  • US 6,790,608 B2
  • Filed: 02/09/2001
  • Issued: 09/14/2004
  • Est. Priority Date: 09/20/2000
  • Status: Expired due to Term
First Claim
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1. A method of identifying an ADP-glucose receptor agonist or antagonist, comprising:

  • (a) contacting an ADP-glucose receptor polypeptide with at least one candidate compound in the presence of ADP-glucose under conditions wherein said receptor produces a G-protein coupled signal in response to ADP-glucose, wherein said ADP-glucose receptor polypeptide has the amino acid sequence designated SEQ ID NO;

    2;

    (b) determining the ability of said candidate compound to alter production of said G-protein coupled signal, wherein a candidate compound that alters production of said signal is identified as an ADP-glucose receptor agonist or antagonist.

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