Human mitochondrial proteins and polynucleotides encoding the same

• US 6,790,667 B1
• Filed: 05/30/2001
• Issued: 09/14/2004
• Est. Priority Date: 05/30/2000
• Status: Expired due to Fees

• Current Assignee: Lexicon Genetics, Incorporated
• Original Assignee: Lexicon Genetics, Incorporated
• Inventors: Potter, David George, Hilbun, Erin, Turner, C. Alexander Jr.
• Primary Examiner(s): Rao, Manjunath N.
• Application Number:
  US09/870,113
• Time in Patent Office: 1,203 Days
• Field of Search: 435/4, 435/6, 435/183.T, 435/69.1, 435/252.3 T, 435/320.1 T, 436/86, 536/23.5, 536/23.51
• US Class Current: 436/86
• CPC Class Codes: C07K 14/47 from mammals

Abstract

The present invention relates to methods and compositions for the treatment of biological disorders regulatable by the controlled expression or inhibition of the described NHP.

Claims

1. An isolated nucleic acid molecule comprising a nucleotide sequence encoding an amino acid sequence selected from the group consisting of SEQ ID NOS:

2, 4, 6, and 12.

4. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule comprises a nucleotide sequence encoding the amino acid sequence of SEQ ID NO:

4.

5. The isolated nucleic acid molecule of claim 4, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

3.

6. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule comprises a nucleotide sequence encoding the amino acid sequence of SEQ ID NO:

6.

7. The isolated nucleic acid molecule of claim 6, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

5.

8. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule comprises a nucleotide sequence encoding the amino acid sequence of SEQ ID NO:

12.

9. The isolated nucleic acid molecule of claim 8, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

11.

10. A recombinant expression vector comprising the isolated nucleic acid molecule of claim 1.

11. The recombinant expression vector of claim 10, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

1.

12. The recombinant expression vector of claim 10, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

3.

13. The recombinant expression vector of claim 10, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

5.

14. The recombinant expression vector of claim 10, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

11.

15. A host cell comprising the recombinant expression vector of claim 10.

2. An isolated nucleic acid molecule comprising a nucleotide sequence encoding the amino acid sequence of SEQ ID NO:

2.

3. The isolated nucleic acid molecule of claim 2, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

1.