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Diphenylalkylamine derivatives useful as opioid receptor agonists

  • US 6,790,854 B2
  • Filed: 03/13/2003
  • Issued: 09/14/2004
  • Est. Priority Date: 03/24/2000
  • Status: Expired due to Fees
First Claim
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1. A compound represented by the following general formula (I) or a salt thereof:

  • embedded imagewherein, X represents the following group (II), (III), (IV), (V), or (VI), embedded imagen represents 1, 2 or 3, R1 and R2 each independently represent a hydrogen atom, a halogen atom, a lower alkyl group which may be substituted, a lower alkenyl group which may be substituted, a lower alkoxy group which may be substituted or a hydroxy group, or R1 and R2 are combined to form the group —

    O—

    CH2

    O—

    , R3 represents a hydrogen atom, a halogen atom, a lower alkyl group which may be substituted, a lower alkenyl group which may be substituted, a lower alkoxy group which may be substituted, a hydroxy group, a cyano group, an amino group which may be substituted, a carbamoyl group which may be substituted, a carboxyl group, a (substituted or unsubstituted lower alkoxy)carbonyl group or a (substituted or unsubstituted lower alkyl)carbonyl group, R4 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group or a monocyclic or bicyclic heterocyclic group containing one or more hetero atoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom, a lower alkyl group which may be substituted, or a lower alkenyl group which may be substituted, and R3 and R4, R5 and R6, R7 and R8, or R9 and R10 may be linked to each other to form a cyclic structure.

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