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Thyromimetic organic compounds

  • US 6,790,978 B2
  • Filed: 09/28/2001
  • Issued: 09/14/2004
  • Est. Priority Date: 03/29/1999
  • Status: Expired due to Fees
First Claim
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1. A method for the preparation of a compound of the formula embedded imagein which R1 is hydroxy, R4 is optionally substituted alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl;

  • R2 is hydrogen, halogen or lower alkyl;

    R3 is halogen or lower alkyl; and

    n represents zero or an integer from 1 to 4;

    or a pharmaceutically acceptable salt thereof;

    which method comprises;

    (a) condensing the amine of the formula embedded imagewith a reactive functional derivative of an acid, said acid being a carboxylic acid of the formula

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