Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
First Claim
1. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
- a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site.
9 Assignments
0 Petitions
Accused Products
Abstract
An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual'"'"'s finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual'"'"'s finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual'"'"'s finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual'"'"'s body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.
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Citations
43 Claims
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1. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site. - View Dependent Claims (2, 4, 8, 14, 15, 16, 17, 18, 19, 20, 22, 23, 28, 29, 30, 31, 32, 34, 35, 36, 41, 42, 43)
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3. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site;
said distal end portion of said device is being shaped to in part overlie a portion of the tip of the individual'"'"'s finger to facilitate retention of the device on the individual'"'"'s finger.
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5. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site; and
a proximal end portion, said distal and proximal end portions being releasably secured to one another;
said proximal end portion carrying said power source, and mating electrical contacts carried by said distal and proximal end portions for electrically connecting said first electrode and said power source upon releasable securement of said proximal and distal portions to one another, said contacts being separable from one another upon separation of the distal and proximal end portions from one another.
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6. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site;
said device including a proximal end portion, said distal and proximal end portions being engageable with one another to form a substantially unitary body along an extent of the individual'"'"'s finger and separable from one another, said proximal end portion carrying said power source, and electrical contacts carried by said distal and proximal end portions, respectively, for electrical contact with one another when said proximal and distal end portions are engaged with one another and electrical disconnection from one another when said proximal and distal end portions are disengaged with one another.
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7. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site;
said device being in part shaped to conform generally with the portion of the individual'"'"'s finger extending from a tip thereof to a location past the first finger joint and including a proximal end portion, said distal and proximal end portions being engageable with one another to form a substantially unitary body along the individual'"'"'s finger and separable from one another, said proximal end portion carrying said power source, electrical contacts carried by said distal and proximal end portions, respectively, and being electrically connected to one another in response to engagement of said distal and proximal end portions with one another for electrically connecting said first electrode and said power source, said contacts being electrically disconnected relative to one another in response to separation of said proximal and distal end portions from one another.
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9. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site;
said device including an elongated body for extending along an outer surface of the individual'"'"'s finger, said distal end portion carrying said second electrode along a side of the device remote from said elongated body for engagement by a fingerprint side of the individual'"'"'s fingertip, said first electrode being carried on a side of said distal end portion remote from the second electrode and the individual'"'"'s fingertip, said second electrode being electrically insulated from said first electrode. - View Dependent Claims (10, 11, 12, 13)
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21. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site;
said second electrode being carried by said shaped part for engagement between said device and the individual'"'"'s finger portion affording electrical contact between the power source and the individual'"'"'s finger through said second electrode, said device including an elongated body extending generally parallel to the individual'"'"'s finger when extended, said distal end portion including a housing carrying said first electrode, said first electrode having a generally planar surface in a plane extending at an angle relative to the elongated body; and
said distal end portion having an enclosure surrounding the individual'"'"'s finger with at least one open end for receiving the individual'"'"'s fingertip within the enclosure, said housing being located on a side of said distal end portion adjacent an underside of the individual'"'"'s finger with the planar surface of said first electrode facing outwardly away from the individual'"'"'s finger.
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24. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site; and
means for preventing completion of the electrical circuit in response to a predetermined number of uses of the device.
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25. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site; and
means for preventing completion of the electrical circuit in response to a predetermined time duration corresponding to an aggregate total time usage.
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26. An electrokinetic delivery system for personal use in self-administration to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically driving the medicament into the treatment site; and
means for inactivating said device for a predeterminded time period and means for reactivating said device after said predetermined time period.
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27. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained power source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said power source;
a second electrode carried by said device for electrical contact with a portion of the individual'"'"'s body, said second electrode being in electrical contact with said power source whereby, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and completion of an electrical circuit through the first electrode, the medicament or conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source, said device causes an electrical current to flow for electrokinetically drive the medicament into treatment site; and
said device including a proximal end portion, said distal and proximal end portions being releasably secured to one another, and means for preventing reuse of said distal end portion after a one-time use.
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33. An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual, comprising:
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a device for releasable securement to an individual'"'"'s finger and shaped in part to conform to at least a portion of the individual'"'"'s finger;
a retainer for releasably securing the device to the individual'"'"'s finger;
a self-contained alternating current source carried by said device;
a first electrode carried by said device adjacent a distal end portion thereof and adjacent the tip of the individual'"'"'s finger upon retention of the device on the individual'"'"'s finger, said first electrode being in electrical contact with said source;
second and third electrodes carried by said device for electrical contact with a portion of the individual'"'"'s body and in electrical contact with said alternating current source whereby said electrodes, upon application of said first electrode to a treatment site with the medicament interposed between the first electrode and the treatment site and electrical contact between said second and third electrodes and the body, enable uni-directional current flow for electrokinetically driving the medicament into the treatment site and bi-directional current flow in the body.
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37. A method of treatment by electrokinetic self-administration of a medicament into a treatment site for an individual, comprising:
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providing a device shaped in part to conform to at least a portion of an individual'"'"'s finger and having a self-contained power source, first and second electrodes, and a substrate in electrical contact with said first electrode and including an electrokinetically transportable medicament and an exposed contact surface;
releasably retaining the device on the individual'"'"'s finger, with the second electrode in electrical contact with the individual'"'"'s finger;
while the device remains retained on the individual'"'"'s finger, placing the contact surface of said substrate into contact with the individual'"'"'s treatment site; and
causing electrical current to flow through said first electrode, the medicament or a conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source to electrokinetically drive the medicament into the treatment site. - View Dependent Claims (39)
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38. A method of treatment by electrokinetic self-administration of a medicament into a treatment site for an individual, comprising:
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providing a device shaped in part to conform to at least a portion of an individual'"'"'s finger and having a self-contained power source, first and second electrodes, and a substrate in electrical contact with said first electrode and including an electrokinetically transportable medicament and an exposed contact surface;
releasably retaining the device on the individual'"'"'s finger, with the second electrode in electrical contact with the individual'"'"'s finger;
while the device remains retained on the individual'"'"'s finger, placing the contact surface of said substrate into contact with the individual'"'"'s treatment site; and
causing electrical current to flow through said first electrode, the medicament or a conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source to electrokinetically drive the medicament into the treatment site; and
providing said device with discrete separable distal and proximal portions having respective electrical contacts, connecting said distal and proximal portions to one another and electrically coupling the respective electrical contacts of the distal and proximal portions with one another to enable flow of the electrical current.
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40. A method of treatment by electrokinetic self-administration of a medicament into a treatment site for an individual, comprising:
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providing a device shaped in part to conform to at least a portion of an individual'"'"'s finger and having a self-contained power source, first and second electrodes, and a substrate in electrical contact with said first electrode and including an electrokinetically transportable medicament and an exposed contact surface;
releasably retaining the device on the individual'"'"'s finger, with the second electrode in electrical contact with the individual'"'"'s finger;
while the device remains retained on the individual'"'"'s finger placing the contact surface of said substrate into contact with the individual'"'"'s treatment site; and
causing electrical current to flow through said first electrode, the medicament or a conductive carrier therefor, the treatment site, the individual'"'"'s body, said second electrode and said power source to electrokinetically drive the medicament into the treatment site; and
providing said device with discrete separable distal and proximal portion having respective electrical connecting said distal and proximal portions to one another, and electrically coupling said contacts with one another to enable an electrical circuit between said first and second electrodes and though said power source.
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Specification