Premixed calcium phosphate cement pastes

• US 6,793,725 B2
• Filed: 01/23/2002
• Issued: 09/21/2004
• Est. Priority Date: 01/24/2001
• Status: Expired due to Term

• Current Assignee: ADA Foundation
• Original Assignee: ADA Foundation
• Inventors: Takagi, Shozo, Chow, Laurence C.
• Primary Examiner(s): Wood, Elizabeth D.
• Application Number:
  US10/057,554
• Publication Number:
  US 20020137812A1
• Time in Patent Office: 972 Days
• Field of Search: 106/35, 106/690, 106/691
• US Class Current: 106/35
• CPC Class Codes: A61K 6/54 Filling; Sealing
• CPC Class Codes: A61K 6/838 Phosphorus compounds, e.g. apatite
• CPC Class Codes: A61K 6/864 Phosphate cements apatite A61K6/838
• CPC Class Codes: A61K 6/873 Carbonates
• CPC Class Codes: A61K 6/898 Polysaccharides
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: C04B 14/28 of calcium
• CPC Class Codes: C04B 2111/00836 for medical or dental applications
• CPC Class Codes: C04B 22/064 of the alkaline-earth metals
• CPC Class Codes: C04B 22/16 containing phosphorus in the anion, e.g. phosphates
• CPC Class Codes: C04B 24/02 Alcohols; Phenols; Ethers
• CPC Class Codes: C04B 24/383 Cellulose or derivatives thereof
• CPC Class Codes: C04B 28/34 containing cold phosphate binders
• CPC Class Codes: C04B 28/344 the phosphate binder being present in the starting composition solely as one or more phosphates
• CPC Class Codes: C04B 40/0608 Dry ready-made mixtures, e.g. mortars at which only water or a water solution has to be added before use
• CPC Class Codes: C08L 1/284 with hydroxylated hydrocarbon radicals

Abstract

A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate powders, that are capable of forming hydroxyapatite, with liquid glycerol and hydroxypropyl methylcellulose and Na₂HPO₄. The paste will harden upon exposure to water with the time to harden controlled by the choice and ratio of constituents.

Claims

1. A composition of matter for dental restoration and bone implants and restoration comprising, in combination:

a mixture of liquid glycerol and a powdered calcium phosphate compound selected from the group consisting of tetracalcium phosphate;

anhydrous dicalcium phosphate;

α

-tricalcium phosphate with calcium carbonate;

dicalcium phosphate with calcium hydroxide and mixtures thereof, said mixture being free of water and in the form of a paste.

2. The composition of claim 1 including a cellulose compound.

3. The composition of claim 1 including hydroxypropyl methylcellulose.

4. The composition of claim 1 including Na₂HPO₄.

5. The composition of claim 1 including an accelerator.

6. The composition of claim 1 comprising a water free paste comprised of a liquid including glycerol, hydroxypropyl methlycellulose and Na₂HPO₄ and powdered tetracalcium phosphate prepared from dicalcium phosphate and calcium carbonate.

7. A paste for bone and tooth restoration comprising, in combination:

a water free mixture of liquid glycerol and powdered tetracalcium phosphate prepared from dicalcium phosphate and calcium carbonate.

8. The paste of claim 7 wherein the liquid further includes hydroxy methylcellulose.

9. The paste of claim 7 wherein the liquid further includes Na₂NPO₄.

10. The paste of claim 8 wherein the mass ratio of powder to liquid is in the range of 3.5 to 1 to 1.5 to 1.8.