Method and system for sample aliquot storage

• US 6,793,888 B2
• Filed: 07/18/2001
• Issued: 09/21/2004
• Est. Priority Date: 03/16/2001
• Status: Active Grant

• Current Assignee: Beckman Coulter Incorporated (Danaher Corporation)
• Original Assignee: Beckman Coulter Incorporated (Danaher Corporation)
• Inventors: Wilson, Brian D., Weiss, Robert A., Spiess, Bernhard, Werness, Peter G., Qureshi, Humayun, Laska, Ronald C.
• Primary Examiner(s): Ludlow, Jan M.
• Application Number:
  US09/908,169
• Publication Number:
  US 20020132356A1
• Time in Patent Office: 1,161 Days
• Field of Search: 422/63-67, 422/100, 436/43, 436/47, 436/50, 436/180
• US Class Current: 422/63
• CPC Class Codes: G01N 35/0092 Scheduling
• CPC Class Codes: G01N 35/1002 Reagent dispensers
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/115831 Condition or time responsive

Abstract

A method and system of sample aliquot storage for automated immunochemistry or chemistry instruments are provided. The method and system provide a sample aliquot storage unit having a sample storage wheel for storing sample vessels containing sample aliquots in a chilled enclosed environment, which are accessible by both a sample pipettor of a sample aliquoting station and a pick-and-place gripper. The pick-and-place gripper transports the sample vessels containing sample aliquots to multiple independent reagent pipetting stations respectively for sample aspiration of subsequent assay, and thereafter transports the sample vessels containing remaining sample aliquots back to the sample storage wheel to be stored in the chilled environment for reflex testing. When all the tests are completed, the pick-and-place gripper transports the sample vessels to a waste storage area.

Claims

1. An apparatus for automated immunochemistry or chemistry analysis, comprising:

a. a sample aliquot storage unit having a sample storage wheel;

b. a pick-and-place mechanism for transporting empty sample vessels from a bulk vessel feeder to said sample storage wheel;

c. a sample aliquoting station having a sample pipettor for aspirating samples from sample tubes loaded, and aliquoting samples to said empty sample vessels on said sample storage wheel;

d. said sample aliquot storage unit further having a chiller assembly for keeping said sample vessels containing sample aliquots in a chilled environment on said sample storage wheel;

e. said sample aliquot storage unit further having means for driving and controlling said sample storage wheel to position said sample vessels for access by said pipettor of said sample aliquoting station and said pick-and-place mechanism;

f. said pick-and-place mechanism transporting said sample vessels containing said sample aliquots to a multiplicity of independent reagent pipetting stations respectively for sample aspiration of subsequent assay; and

g. said pick-and-place mechanism also transporting said sample vessels containing remaining sample aliquots back to said sample storage wheel to be stored in said chilled environment for reflex testing.

2. The apparatus as defined in claim 1, wherein said chiller assembly of said sample aliquot storage unit comprises a top cover with openings for access of said sample vessels by both said pipettor of said sample aliquoting station and said pick-and-place mechanism.

3. The apparatus as defined in claim 1, wherein said chiller assembly of said sample aliquot storage unit comprises a cold plate for establishing and maintaining said chilled environment.

4. The apparatus as defined in claim 1, wherein said chiller assembly of said sample aliquot storage unit comprises insulation means for establishing and maintaining said chilled environment.

5. The apparatus as defined in claim 1, wherein said chiller assembly of said sample aliquot storage unit comprises cooler members for establishing and maintaining said chilled environment.

6. The apparatus as defined in claim 1, wherein said chiller assembly of said sample aliquot storage unit comprises a heatsink for establishing and maintaining said chilled environment.

7. The apparatus as defined in claim 1, wherein said driving and controlling means of said sample aliquot storage unit comprises a stepper motor and an encoder to accurately position the storage wheel.

8. The apparatus as defined in claim 1, wherein said sample aliquot storage unit further comprises a base.

9. The apparatus as defined in claim 1, further comprising an incubate and wash and read unit for performing said assay.

10. The apparatus as defined in claim 9, further comprising another pick-and-place gripper for transporting vessels between said multiplicity of reagent pipetting stations and said incubate and wash and read unit.

11. The apparatus as defined in claim 1, wherein said sample pipettor of said sample aliquoting station aspirates samples from sample tubes loaded by a sample presentation unit.

12. The apparatus as defined in claim 1, wherein said sample pipettor of said sample aliquoting station aspirates samples from sample tubes presented by a lab automation system or an automated track conveyance system.

13. An apparatus for automated immunochemistry or chemistry analysis, comprising:

a. a sample aliquot storage unit having a sample storage wheel for storing sample vessels;

b. a sample aliquoting station having a sample pipettor for aliquoting samples to said sample vessels on said sample storage wheel;

c. said sample aliquot storage unit, further having a chiller assembly for keeping said sample vessels containing sample aliquots in a chilled environment on said sample storage wheel;

d. said sample aliquot storage unit, further having means for driving and controlling said sample storage wheel to position said sample vessels for access by said pipettor of said sample aliquoting station;

e. a pick-and-place mechanism for transporting said sample vessels containing said sample aliquots to a multiplicity of independent reagent pipetting stations respectively for sample aspiration of subsequent assay; and

f. said pick-and-place mechanism also transporting said sample vessels containing remaining sample aliquots back to said sample storage wheel to be stored in said chilled environment for reflex testing.

14. The apparatus as defined in claim 13, wherein said sample pipettor of said sample aliquoting station aspirates samples from sample tubes loaded by a sample presentation unit.

15. The apparatus as defined in claim 13, wherein said sample pipettor of said sample aliquoting station aspirates samples directly from sample tubes presented by lab automation systems or automated track conveyance systems.

16. The apparatus as defined in claim 13, wherein said pick-and-place mechanism also transports empty sample vessels from a bulk vessel feeder to said sample storage wheel.

17. The apparatus as defined in claim 13, wherein said chiller assembly of said sample aliquot storage unit comprises a top cover with openings for access of said sample vessels by both said pipettor of said sample aliquoting station and said pick-and-place gripper.

18. The apparatus as defined in claim 13, wherein said chiller assembly of said sample aliquot storage unit comprises a cold plate for establishing and maintaining said chilled environment.

19. The apparatus as defined in claim 13, wherein said chiller assembly of said sample aliquot storage unit comprises insulation means for establishing and maintaining said chilled environment.

20. The apparatus as defined in claim 13, wherein said chiller assembly of said sample aliquot storage unit comprises cooler members for establishing and maintaining said chilled environment.

21. The apparatus as defined in claim 13, wherein said chiller assembly of said sample aliquot storage unit comprises a heatsink for establishing and maintaining said chilled environment.

22. The apparatus as defined in claim 13, wherein said driving and controlling means of said sample aliquot storage unit comprises a motor.

23. The apparatus as defined in claim 13, wherein said sample aliquot storage unit further comprises a base.