Detection of analytes in aqueous environments
First Claim
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1. An indicator macromolecule for detecting the presence or concentration of an analyte in an aqueous environment, said macromolecule comprising a copolymer of:
- a) one or more indicator component monomers which individually are not sufficiently water soluble to permit their use in an aqueous environment for detecting the presence or concentration of said analyte; and
b) one or more hydrophilic monomers;
such that the macromolecule is capable of detecting the presence or concentration of said analyte in an aqueous environment.
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Abstract
The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.
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Citations
65 Claims
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1. An indicator macromolecule for detecting the presence or concentration of an analyte in an aqueous environment, said macromolecule comprising a copolymer of:
-
a) one or more indicator component monomers which individually are not sufficiently water soluble to permit their use in an aqueous environment for detecting the presence or concentration of said analyte; and
b) one or more hydrophilic monomers;
such that the macromolecule is capable of detecting the presence or concentration of said analyte in an aqueous environment.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 65)
9-[[N-methacryloylaminopropyl-N-(o-boronobenzyl) amino]-methyl]anthracene; 9-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[3-(methacrylamido) propylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan -2-yl)benzyl]-N-[2-(2-hydroxyethoxy)-ethylamino ]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[3-(methacrylamido)-propylaminolmethyl]-10-(N-(2-boronobenzyl)-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[3-(methacrylamido) propylaminolmethyl]anthracene;
9,10-bis [N-(2-boronobenzyl)-N-[3-(methacrylamido)-propylamino]methyl]anthracene;
9-N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[2-(2-hydroxyethoxy)-ethylamino ]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy)-ethylamino]methyl]-10-[N-[2-boronobenzyl)]-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9, 10-bis (N-[2-(5, 5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene;
9, 10-bis [N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene; and
salts or derivatives thereof.
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5. The indicator macromolecule of claim 3, wherein the hydrophilic monomer comprises [3-(methacryloylamino)-propyl]trimethylammonium chloride.
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6. The indicator macromolecule of claim 1, wherein the indicator component monomer is selected from the group consisting of a lanthanide chelate and a polyaromatic hydrocarbon.
-
7. The indicator macromolecule of claim 1, wherein the molar ratio of hydrophilic monomer:
- indicator component momomer is from about 2;
1 to about 1000;
1.
- indicator component momomer is from about 2;
-
8. The indicator macromolecule of claim 7, wherein the ratio of hydrophilic monomer:
- indicator component momomer is from about 5;
1 to about 50;
1.
- indicator component momomer is from about 5;
-
9. The indicator macromolecule of claim 8, wherein the ratio of hydrophilic monomer:
- indicator component momomer is about 5;
1.
- indicator component momomer is about 5;
-
10. The indicator macromolecule of claim 1, wherein the analyte detected is selected from the group consisting of a vicinal diol;
- an α
-hydroxy acid, a β
-keto acid oxygen;
carbon dioxide;
zinc, potassium, hydrogen, or carbonate ions;
a toxin;
a mineral; and
a hormone.
- an α
-
11. The indicator macromolecule of claim 10, wherein the analyte detected is a vicinal diol which comprises a saccharide.
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12. The indicator macromolecule of claim 11, wherein the saccharide is glucose.
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13. The indicator macromolecule of claim 1, wherein
i) the molar ratio of hydrophilic monomer: - indicator component momomer is from about 2;
1 to about 15;
1,ii) the indicator component monomer comprises an N-(o-boronobenzyl) amino]methyl]anthracene derivative, iii) the hydrophilic monomer comprises [3-(methacryloylamino) propyl]trimethylammonium chloride, and iv) the macromolecule exhibits an excimer effect.
- indicator component momomer is from about 2;
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14. The indicator macromolecule of claim 1, wherein the indicator component monomer is selected from the group consisting of:
N-[3-(methacrylamido)propyl]-3,4-dihydroxy-9,10-dioxo-2-anthracenesulfonamide;
α
,α
′
-bis [N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[3-(methacrylamido)propylamino]-1, 4-xylene; and
salts or derivatives thereof.
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65. The method of claim 4, wherein the indicator component monomer is selected from the group consisting of:
-
N-[3-(methacrylamido)propyl]-3, 4-dihydroxy-9,10-dioxo-2-anthracenesulfonamide;
α
,α
′
-bis[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[3-(methacrylamido)propylamino]-1,4-xylene; and
salts or derivatives thereof.
-
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15. A method for the production of an indicator macromolecule for detecting the presence or concentration of an analyte in an aqueous environment, said method comprising copolymerizing:
-
a) one or more indicator component monomers which individually are not sufficiently water soluble to permit their use in an aqueous environment for detecting the presence or concentration of said analyte; and
b) one or more hydrophilic monomers;
such that the resulting macromolecule is capable of detecting the presence or concentration of said analyte in an aqueous environment.- View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
9-[[N-methacryloylaminopropyl-N-(o-boronobenzyl) amino]-methyl]anthracene; 9-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[3-(methacrylamido) propylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[2-(2-hydroxyethoxy)-ethyl amino]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[3-(methacrylamido)-propylamino]methyl]-10-[N-(2-boronobenzyl)-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis[N-[2-(5,5-dimethyl-[1, 3, 2]dioxaborinan-2-yl) benzyl]-N-[3-(*methacrylamido)propylamino]methyl]anthracene;
9, 10-bis [N-(2-boronobenzyl)-N-[3-(methacrylamido)-propylamino]methyl]anthracene;
9-[N-[2-(5, 5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[2-(2-hydroxyethoxy)-ethylamino]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy)-ethylamino]methyl]-10-[N-[2-boronobenzyl)]-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-[2-(5,5-dimethyl-[1,3,2dioxaborinan-2-yl) benzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl) anthracene; and
salts or derivatives thereof.
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19. The method of claim 15, wherein the hydrophilic monomer comprises [3-(methacryloylamino)-propyl]trimethylammonium chloride.
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20. The method of claim 15, wherein the indicator component monomer is selected from the group consisting of a lanthanide chelate and a polyaromatic hydrocarbon.
-
21. The method of claim 15, wherein the molar ratio of hydrophilic monomer:
- indicator component momomer is from about 2;
1 to about 1000;
1.
- indicator component momomer is from about 2;
-
22. The method of claim 21, wherein the ratio of hydrophilic monomer:
- indicator component momomer is from about 5;
1 to about 50;
1.
- indicator component momomer is from about 5;
-
23. The method of claim 22, wherein the ratio of hydrophilic monomer:
- indicator component momomer is about 5;
1.
- indicator component momomer is about 5;
-
24. The method of claim 15, wherein the analyte detected is selected from the group consisting of a vicinal diol;
- an α
-hydroxy acid;
a β
-keto acid;
oxygen;
carbon dioxide;
zinc, potassium, hydrogen, or carbonate ions;
a toxin;
a mineral; and
a hormone.
- an α
-
25. The method of claim 24, wherein the analyte detected is a vicinal diol which comprises a saccharide.
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26. The method of claim 25, wherein the saccharide is glucose.
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27. The method of claim 15, wherein
i) the molar ratio of hydrophilic monomer: - indicator component momomer is from about 2;
1 to about 15;
1,ii) the indicator component monomer comprises an N-(o-boronobenzyl) aminomethylanthracene derivative, iii) the hydrophilic monomer comprises [3-(methacryloylamino) propyl]trimethylammonium chloride, and iv) the macromolecule exhibits an excimer effect.
- indicator component momomer is from about 2;
-
28. The method of claim 15, wherein the indicator component monomer is selected from the group consisting of:
-
N-[3-(methacrylamido) propyl]-3, 4-dihydroxy-9, 10-dioxo-2-anthracenesulfonamide;
α
,α
-bis-(2-(5, 5-dimethyl-[1,3,2°
dioxaborinan-2-yl) benzyl[-N-[3-(methacrylamido)propylamino]-1, 4-xylene; and
salts or derivatives thereof.
-
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29. A method for detecting the presence or concentration of an analyte in a sample having an aqueous environment, said method comprising:
-
a) exposing the sample to an indicator macromolecule, said macromolecule comprising a copolymer of;
i) one or more indicator component monomers which individually are not sufficiently water soluble to permit their use in an aqueous environment for detecting the presence or concentration of said analyte; and
ii) one or more hydrophilic monomers;
such that the resulting macromolecule is capable of detecting the presence or concentration of said analyte in an aqueous environment, and wherein the indicator macromolecule has a detectable quality that changes in a concentration-dependent manner when said macromolecule is exposed to said analyte; and
b) measuring any change in said detectable quality to thereby determine the presence or concentration of said analyte in said sample. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
9-[[N-methacryloylaminopropyl-N-(o-boronobenzyl) amino]-methyl]anthracene; 9-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[3-(methacrylamido) propylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[2-(2-hydroxyethoxy)-ethylamino]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[3-(methacrylamido)-propylamino]methyl]-10-[N-(2-boronobenzyl)-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-(2-(5,5-dimethyl-[1,3,2dioxaborinan-2-yl) benzyl]-N-[3-(methacrylamido) propyl amino]methyl]anthracene;
9,10-bis [N-(2-boronobenzyl)-N-[3-(methacrylamido)-propyl amino]methyl anthracene;
9-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1, 3,2]dioxaborinan-2-yl)benzyl]-N-[2-(2-hydroxyethoxy)-ethyl amino]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy)-ethylamino]methyl]-10-[N-[2-boronobenzyl)]-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-(2-boronobenzyl)-N-(2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene; and
salts or derivatives thereof.
-
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33. The method of claim 29, wherein the hydrophilic monomer comprises [3-(methacryloylamino)-propyl]trimethylammonium chloride.
-
34. The method of claim 29, wherein the indicator component monomer is selected from the group consisting of a lanthanide chelate and a polyaromatic hydrocarbon.
-
35. The method of claim 29 wherein the molar ratio of hydrophilic monomer:
- indicator component momomer is from about 2;
2 to about 1000;
1.
- indicator component momomer is from about 2;
-
36. The method of claim 35, wherein the ratio of hydrophilic monomer:
- indicator component momomer is from about 5;
1 to about 50;
1.
- indicator component momomer is from about 5;
-
37. The method of claim 36 wherein the ratio of hydrophilic monomer:
- indicator component momomer is about 5;
1.
- indicator component momomer is about 5;
-
38. The method of claim 29, wherein the analyte detected is selected from the group consisting of a vicinal diol:
- an α
-hydroxy acid;
a β
-keto acid;
oxygen;
carbon dioxide;
zinc, potassium, hydrogen, or carbonate ions;
a toxin;
a mineral; and
a hormone.
- an α
-
39. The method of claim 38, wherein the analyte detected is a vicinal did which comprises a saccharide.
-
40. The method of claim 39, wherein the saccharide is glucose.
-
41. The method of claim 29, wherein
i) the molar ratio of hydrophilic monomer: - indicator component momomer is from about 2;
1 to about 15;
1,ii) the indicator component monomer comprises an N-(o-boronobenzyl) aminomethylarithracene derivative, iii) the hydrophilic monomer comprises [3-(methacryloylamino) propyl]trimethylammonium chloride, and iv) the macromolecule exhibits an excimer effect.
- indicator component momomer is from about 2;
-
42. The method of claim 41, wherein said macromolecule serves as both an indicator and a reference.
-
43. The method of claim 29, wherein the indicator component monomer is selected from the group consisting of:
-
N-[3-(methacrylamido)propyl]-3,4-dihydroxy-9,10-dioxo-2-anthracenesulfonamide;
α
,α
′
-bis[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[3-(methacrylamido) propylamino]-1, 4-xylene; and
salts or derivatives thereof.
-
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44. A macromolecule which is capable of exhibiting an excimer effect, which comprises a copolymer of:
-
a) one or more excimer forming monomers, the molecules of which are capable of exhibiting an excimer effect when suitably oriented with respect to each other; and
b) one or more other monomers;
such that the resulting macromolecule exhibits said excimer effect.- View Dependent Claims (45, 46, 47, 48, 49, 50, 51)
a) the excimer forming monomer individually is not sufficiently water soluble to permit its use in an aqueous environment for detecting the presence or concentration of said analyte; - and
b) the other monomer is a hydrophilic monomer;
such that the macromolecule is capable of detecting the presence or concentration of said analyte in an aqueous environment.
-
-
47. The macromolecule of claim 45, wherein the excimer effect does not substantially change in response to changes in the presence or concentration of the analyte.
-
48. The macromolecule of claim 47, wherein
i) the molar ratio of other monomer: - excimer forming momomer is from about 2;
1 to about 15;
1,ii) the excimer forming monomer comprises an N-(o-boronobenzyl) aminomethylanthracene derivative, and iii) the other monomer comprises [3-(methacryloylamino) propyl]trimethylammonium chloride.
- excimer forming momomer is from about 2;
-
49. The macromolecule of claim 44, wherein the excimer forming monomer is selected from the group consisting of a lanthanide chelate and a polyaromatic hydrocarbon.
-
50. The macromolecule of claim 48, wherein the excimer forming monomer is selected from the group consisting of
9-[[N-methacryloylaminopropyl-N-(o-boronobenzyl) amino]-methyl]anthracene; -
9-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[3-(methacrylamido) propylamino]methyl]-10-[N-[2-(5, 5-dimethyl[1,3,2]dioxaborinan-2-yl)benzyl]-N-[2-(2-hydroxyethoxy)-ethylamino]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-]3-(methacrylamido)-propylaminolmethyl]-10-[N-(2-boronbenzyl)-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-(3-(methacrylamido) propylamino]methyl]anthracene;
9, 10-bis [N-(2-boronobenzyl)-N-[3-(methacrylamido)-propylamino]methylanthracene;
9-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[2]-(2-methacroyloxyethoxy) ethylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[2-(2-hydroxyethoxy)-ethylamino]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy)-ethylamino]methyl]-10-[N-(2-boronobenzyl)-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-(2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene; and
salts or derivatives thereof.
-
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51. The macromolecule of claim 44, wherein the excimer forming monomer is selected from the group consisting of:
-
N-[3-(methacrylamido)propyl]-3,4-dihydroxy-9,10-dioxo-2-anthracenesulfonamide;
α
,α
′
-bis[N-]2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) enzyl]-N-[3-(methacrylamido)propylamino]-1,4-xylene; and
salts or derivatives thereof.
-
-
52. A method for producing a macromolecule which is capable of exhibiting an excimer effect, which method comprises copolymerizing:
-
a) one or more excimer forming monomers, the molecules of which are capable of exhibiting an excimer effect when suitably oriented with respect to each other; and
b) one or more other monomers;
such that the resulting macromolecule exhibits said excimer effect.- View Dependent Claims (53, 54, 55, 56, 57, 58, 59)
a) the excimer forming monomer individually is not sufficiently water soluble to permit its use in an aqueous environment for detecting the presence or concentration of said analyte; - and
b) the other monomer is a hydrophilic monomer;
such that the macromolecule is capable of detecting the presence or concentration of said analyte in an aqueous environment.
-
-
55. The method of claim 53, wherein the excimer effect does not substantially change in response to changes in the presence or concentration of the analyte.
-
56. The method of claim 53, wherein
i) the molar ratio of other monomer: - excimer forming momomer is from about 2;
1 to about 15;
1,ii) the excimer forming monomer comprises an N-(o-boronobenzyl) aminomethylanthracene derivative, and iii) the other monomer comprises [3-(methacryloylamino) propyl]trimethylammonium chloride.
- excimer forming momomer is from about 2;
-
57. The method of claim 52, wherein the excimer forming monomer is selected from the group consisting of a lanthanide chelate and a polyaromatic hydrocarbon.
-
58. The method of claim 56, wherein the excimer forming monomer is selected from the group consisting of
9-[[N-methacryloylaminopropyl-N-(o-boronobenzyl) amino]-methyl]anthracene; -
9[-N-(2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[3-(methacrylamido) propylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[2-(2-hydroxyethoxy)-ethyl amino]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[3-(methacrylamido)-propylamino]methyl]-10-(N-(2-boronobenzyl)-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[3-(methacrylamido) propylamino]methyl]anthracene;
9,10-big [N-(2-boronobenzyl)-N-[3-(methacrylamido)-propylamino]methyl]anthracene;
9-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1, 3,2]dioxaborinan-2-yl) benzyl]-N-[2-(2-hydroxyethoxy)-ethylamino]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy)-ethylamino]methyl]-10-[N-(2-boronobenzyl)-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-[2-(5, 5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene; and
salts or derivatives thereof.
-
-
59. The method of claim 52, wherein the excimer forming monomer is selected from the group consisting of:
-
N-[3-(methacrylamido)propyl]-3, 4-dihydroxy-9,10-dioxo-2-anthracenesulfonamide;
α
,α
′
-bis[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[3-(methacrylamido)propylamino]-1,4-xylene; and
salts or derivatives thereof.
-
-
60. A method for detecting the presence or concentration of an analyte in a sample, said method comprising:
-
a) exposing the sample to an indicator macromolecule, said macromolecule comprising a copolymer of;
i) one or more indicator component monomers, the molecules of which are capable of exhibiting an excimer effect when suitably oriented with respect to each other, and which are also capable of detecting the presence or concentration of an analyte; and
ii) one or more other monomers;
such that the resulting macromolecule exhibits said excimer effect, and wherein the indicator macromolecule has a detectable quality that changes in a concentration-dependent manner when said macromolecule is exposed to said analyte; and
b) measuring any change in said detectable quality to thereby determine the presence or concentration of said analyte in said sample. - View Dependent Claims (61, 62, 63, 64)
i) the molar ratio of other monomer: - indicator component momomer is from about 2;
1 to about 15;
1,
ii) the indicator component monomer comprises an N-(o-boronobenzyl) amino]methyl]anthracene derivative, and iii) the other monomer comprises [3-(methacryloylamino) propyl]trimethylammonium chloride.
-
-
63. The method of claim 60, wherein the indicator component monomer is selected from the group consisting of a lanthanide chelate and a polyaromatic hydrocarbon.
-
64. The method of claim 62, wherein the indicator component monomer is selected from the group consisting of
9-[[N-methacryloylaminopropyl-N-(o-boronobenzyl) amino]-methyl]anthracene; -
9-[N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy)-ethylaminolmethyl]-10-[N-(2-boronobenzyl)-N-[2-(2-hydroxyethoxy) ethylamino]methyl]-anthracene;
9,10-bis [N-(2-boronobenzyl)-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene;
9-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[3-(methacrylamido) propylamino]methyl]-10-[N-[2-(5, 5-dimethyl-[1,3,2dioxaborinan-2-yl)benzyl]-N-[2-(2-hydroxyethoxy)-ethylamino]methyl]anthracene;
9-[N-(2-boronobenzyl)-N-[3-(methacrylamido)-propylamino]methyl]-10-[N-(2-boronobenzyl)-N-[2-(2-hydroxyethoxy) ethylamino]methyl]anthracene;
9,10-bis [N-[2-(5, 5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[3-(methacrylamido) propylamino]methyl]anthracene;
9,10-bis [N-(2-boronobenzyl)-N-]3-(methacrylamido)-propylamino]methyl]anthracene;
9-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]-10-[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) benzyl]-N-[2-(2-hydroxyethoxy)-ethylamino]methyl]anthracene;
9,10-bis[N-[2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl) enzyl]-N-[2-(2-methacroyloxyethoxy) ethylamino]methyl]anthracene; and
salts or derivatives thereof.
-
Specification