Cerebral perfusion augmentation
First Claim
1. A method for increasing cerebral blood flow, comprising the steps of:
- providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end, and a lumen extending from the proximal end and communicating with a port distal the expandable member;
advancing the distal end of the catheter into the descending aorta;
locating the expandable member downstream from the takeoff of a carotid artery; and
expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole, wherein blood pressure in the proximal aorta is altered.
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Accused Products
Abstract
Methods are provided for partial aortic occlusion for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. A catheter is advanced into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region. The expandable member is located downstream from the takeoff of a carotid artery. The expandable member is expanded to at least partially obstruct blood flow in the aorta. A physiologic parameter is measured that indicates adequacy of cerebral perfusion. The expansion of the expandable member is adjusted based on the measured physiologic parameter. Other medical devices, such as an atherectomy catheter, can be inserted distal the occluder to provide therapeutic intervention.
53 Citations
37 Claims
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1. A method for increasing cerebral blood flow, comprising the steps of:
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providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end, and a lumen extending from the proximal end and communicating with a port distal the expandable member;
advancing the distal end of the catheter into the descending aorta;
locating the expandable member downstream from the takeoff of a carotid artery; and
expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole, wherein blood pressure in the proximal aorta is altered. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for increasing cerebral blood flow, comprising the steps of:
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providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end, and a lumen extending from the proximal end and communicating with a port distal the expandable member;
advancing the distal end of the catheter into the descending aorta;
locating the expandable member downstream from the takeoff of a carotid artery; and
expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole, wherein blood pressure or wave form in the proximal aorta is altered. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A method for increasing cerebral blood flow, comprising the steps of:
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providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end;
advancing the distal end of the catheter into the descending aorta;
locating the expandable member downstream from the takeoff of a carotid artery;
expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole; and
measuring a first blood pressure at one of a location proximal or distal the expandable member. - View Dependent Claims (14, 15, 16, 17)
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18. A method for increasing cerebral blood flow, comprising the steps of:
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advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;
locating the expandable member downstream from the takeoff of a carotid artery;
expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole;
measuring a physiologic parameter that indicates adequacy of cerebral perfusion; and
adjusting the expansion of the expandable member based on the measured physiologic parameter. - View Dependent Claims (19, 20, 21, 22, 23, 24)
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25. A method for increasing cerebral blood flow, comprising the steps of:
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advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;
locating the expandable member downstream from the takeoff of a carotid artery;
expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole;
measuring a physiologic parameter; and
adjusting the expansion of the expandable member if the measured physiologic parameter falls outside of a predetermined range. - View Dependent Claims (26, 27, 28, 29, 30, 31)
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32. A method for increasing cerebral blood flow, comprising the steps of:
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providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end;
advancing the distal end of the catheter into the descending aorta;
locating the expandable member downstream from the takeoff of a carotid artery;
expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole;
measuring a first blood pressure at a location proximal the expandable member and measuring a second blood pressure at a location distal the expandable member; and
adjusting the expandable member based on a comparison of the first and second measured blood pressures. - View Dependent Claims (33, 34)
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35. A method for increasing cerebral blood flow, comprising the steps of:
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providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end;
advancing the distal end of the catheter into the descending aorta;
locating the expandable member downstream from the takeoff of a carotid artery;
expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole;
measuring a physiologic parameter; and
adjusting the expansion of the expandable member if the measured physiologic parameter falls outside of a predetermined range. - View Dependent Claims (36, 37)
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Specification