Delivery of muscle relaxants through an inhalation route
First Claim
1. A composition for delivery of a muscle relaxant comprising a condensation aerosola) formed by volatilizing a muscle relaxant under conditions effective to produce a heated vapor of the muscle relaxant and condensing the heated vapor of the muscle relaxant to form condensation aerosol particles;
- b) wherein said condensation aerosol particles are characterized by less than 5% muscle relaxant degradation products, and c) the aerosol has an MMAD less than 3 microns.
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Abstract
The present invention relates to the delivery of muscle relaxants through an inhalation route. Specifically, it relates to aerosols containing a muscle relaxant that is used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of muscle relaxant. In a method aspect of the present invention, a muscle relaxant is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a muscle relaxant, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a muscle relaxant through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a muscle relaxant; and, b) a device that forms a muscle relaxant containing aerosol from the composition, for inhalation by the mammal.
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Citations
14 Claims
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1. A composition for delivery of a muscle relaxant comprising a condensation aerosol
a) formed by volatilizing a muscle relaxant under conditions effective to produce a heated vapor of the muscle relaxant and condensing the heated vapor of the muscle relaxant to form condensation aerosol particles; -
b) wherein said condensation aerosol particles are characterized by less than 5% muscle relaxant degradation products, and c) the aerosol has an MMAD less than 3 microns.
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2. A composition for delivery quinine, chlorzoxazone, carisprodol or cyclobenzaprine comprising a condensation aerosol
a) formed by volatilizing quinine, chlorzoxazone, carisprodol or cyclobenzaprine under conditions effective to produce a heated vapor of quinine, chlorzoxazone, carisprodol or cyclobenzaprine comprising and condensing the heated vapor of the quinine, chlorzoxazone, carisprodol or cyclobenzaprine to form condensation aerosol particles; -
b) wherein said condensation aerosol particles are characterized by less than 5% quinine, chlorzoxazone, carisprodol or cyclobenzaprine degradation products, and c) the aerosol has an MMAD less than 3 microns. - View Dependent Claims (3, 4, 5)
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6. The composition according to claim 6, wherein the aerosol particles comprise at least 97 percent by weight of quinine, chlorzoxazone, carisprodol or cyclobenzaprine.
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7. A method of producing quinine, chlorzoxazone, carisprodol or cyclobenzaprine in an aerosol form comprising:
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a) volatilizing quinine, chlorzoxazone, carisprodol or cyclobenzaprine under conditions effective to produce a heated vapor of the drug, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the quinine, chlorzoxazone, carisprodol or cyclobenzaprine comprising less than 5% quinine, chlorzoxazone, carisprodol or cyclobenzaprine degradation products and an aerosol having an MMAD less than 3 microns. - View Dependent Claims (8, 9, 10, 11, 12, 13)
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14. A method of producing a muscle relaxant in an aerosol form comprising:
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a) volatilizing a muscle relaxant under conditions effective to produce a heated vapor of the muscle relaxant, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the muscle relaxant comprising less than 5% muscle relaxant degradation products and an aerosol having an MMAD less than 3 microns.
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Specification